5. Nanosense
1. Heat-Transfer Resistance Based Analysis of Bioparticles
(US2014011198)
▪ Applicants: IMEC and UHasselt
▪ Status: granted in EP, close to granting in US
▪ Scope: biosensing device for detection and/or characterization of target
DNA and/or RNA bioparticles
▪ Current application not covered by this patent
2. Heat-Transfer Resistance Based Analysis of Bioparticles
(US2014242605)
▪ Applicants: IMEC and UHasselt
▪ Status: EP-search report available, office action March 2015
▪ Scope: biosensing device for detection and/or characterization of target
bioparticles, a.o. cells or small molecules
▪ Current application covered by this patent application
IP
7. Proof-of-concept
The technique has been proven for:
TARGETs: nicotine, serotonin, histamine, caffeïne, malachite green,
biogenic amines, …
ANALYTEs: buffer solutions, water, saliva, urine, blood plasma, whole
blood, …
Dose-response curve of
nicotine in PBS
=> LOD ~ 30 nM
HTM-determination
of serotonin in non-diluted blood plasma
Marloes Peeters et al., Analytical and Bioanalytical Chemistry 405, 6479 – 6487 (2013)
Bram Geerets et al., Sensors 13, 9148 – 9159 (2013).
8. State-of-the-art
- Use of bulk-MIPs
- Stamping technique / spraycaoting
- Flow-cell and drop-cell
- Home-made setup
9. Valorisation
• What are the most interesting TARGETs? (market
potential, emerging technologies, FTO, etc.)
• Detection limits and dynamic range?
• Complexity of the analytes (preparation necessary?)
• Single testing or multi-parameter testing?
ENVIRONMENTAL FOOD SAFETY HEALTH
