This report on Biological Implants analyzes the global market for biological implant procedures. The total biological implants market is analyzed by tissue/muscle; origin, and mode of administration at global level and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World. The biological implants market is segmented by Tissue/Muscle into Soft Tissue, Orthopedic, Cardiovascular and Other (includes Dental, Ophthalmic, and Urologic); by Origin into Allograft, and Xenograft; and by Mode of Administration into Injectable and Surgical. Business profiles of 25 major companies are discussed in the report. The report serves as a guide to global biological implants industry covering more 140 companies that are engaged in biological implants? processing, R&D, storage, banking, discovery, testing and supply of products and services. Major Contract Research Organizations and Universities serving the industry are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory affairs, and other areas of concern is also covered in the report. Compilation of Worldwide Patents and Research related to biological implants is also provided. Estimations and Predictions are graphically illustrated by geographic regions by 117 exclusive exhibits.

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BIOLOGICAL IMPLANTS MARKET SIZE
Scope of the Study
Biological Implants Report provides a progressive insight into the market for several types of Bioimplants by
Origin and Mode of Administration. The product is segmented by Tissue/Muscle into Orthopedic, Soft
Tissue, Cardiovascular, and Other (Dental, Ophthalmic and Urologic). The market is further analyzed by
origin (Allograft and Xenograft), and by mode of administration (Injectable and Surgical).
Projections and estimates are graphically illustrated by geographic regions encompassing North America,
Europe, Asia-Pacific, and Rest of World. Business profiles of 25 major companies are discussed in the
report. The report serves as a guide to global Biological Implants industry covering more than 164
companies that are engaged in Bioimplant R&D, manufacturing, testing and supply of products and
services. Major Contract Research Organizations and Universities serving the industry are also covered in
the Corporate Directory section of this report. Information related to recent product releases, product
developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory affairs, and
other areas of concern is also covered in the report.
This research report on Biological Implants is an ideal research tool providing strategic business intelligence
to the corporate sector. This report may help strategists, investors, laboratories, pharmaceutical
companies, contract research organizations, biotechnology companies and drug approval authorities in--
 Gauging Competitive Intelligence
 Identifying Key Growth Areas and Opportunities
 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
Analytics and data presented in this report pertain to several parameters such as –
 Global And Regional Market Sizes, Market Shares, Market Trends
 Product (Global And Regional) Market Sizes, Market Shares, Market Trends
 Technology Trends
 Corporate Intelligence
 Key Companies By Sales, Brands, Products
 Consumer Behavioral Patterns

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 Other Strategic Business Affecting Data
Research Methodology
RI Technologies publishes business intelligence reports by going through a cycle of diligent research and
analysis activity. Research is done using both online and offline resources. The study outline of this report is
sketched on the following lines – global market analysis, regional market analysis, product segmentation,
global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape,
technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is
also helpful for doing market evaluations, and estimating the market size for the future.
This report is uniquely researched and the methodology includes:
 Need and Scope of Study
 Product Definitions
 Segmental Analysis
 Regional Analysis
 Exclusive Data Analytics
 Corporate Intelligence
 Feedback
Right from concept to final compilation of this report, both primary and secondary research methods are
applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the
information for authentication of our own findings. Secondary research includes government publications,
investment research reports, web based surveys, website information of both companies and markets, and
other offline resources such as print publications and CDs.
Our compilation of easy to navigate PDF reports are essential value addition resources for leading and
growing companies.

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II. REPORT SYNOPSIS
FOREWORD
Biological Implants – A Revolutionary Human Repair Technique
Biological Implants are testimony to the huge advancements in medical science. The development of
different types of implantable biomaterials according to the specified strength characteristics, conservation
of significant biochemical properties, the lower immunogenity and higher inductivity of regenerative
processes enables to carry out appropriate studies on the biochemical reactions following the implantation
of biomaterials. This illustrates the peculiarities of the regeneration processes of various types of
bioimplant materials during the application.
These implants are predicted to enhance the quality of life. The blend of scientific research, clinical
application and commercial advancement has created a new outlook to the treatment based on biological
implants. The prospects of the use of materials in different areas of surgery, the protection against
infection and the use of biological implants outside the authorized indications are of main concern. This
report analyzes the current biological implant procedures. Synopsis chapter of the report gives the
summary of total biological implants market by tissue/muscle; origin, and mode of administration at global
level and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World.
Segmentation of Biological Implants
This report on Biological Implants analyzes the global market for biological implant procedures. The total
biological implants market is analyzed by tissue/muscle; origin, and mode of administration at global level
and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World. The
biological implants market is segmented by Tissue/Muscle into Soft Tissue, Orthopedic, Cardiovascular and
Other (includes Dental, Ophthalmic, and Urologic); by Origin into Allograft, and Xenograft; and by Mode of
Administration into Injectable and Surgical. Business profiles of 25 major companies are discussed in the
report. The report serves as a guide to global biological implants industry covering more 140 companies
that are engaged in biological implants’ processing, R&D, storage, banking, discovery, testing and supply of
products and services. Major Contract Research Organizations and Universities serving the industry are also
covered in the Corporate Directory section of this report. Information related to recent product releases,
product developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory
affairs, and other areas of concern is also covered in the report. Compilation of Worldwide Patents and
Research related to biological implants is also provided. Estimations and Predictions are graphically
illustrated by geographic regions by 229 exclusive exhibits.

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Exhibit 1. Segmentation of Global Biological Implants Market by Tissue/Muscle, by Origin, and by Mode
of Administration
Tissue/Muscle Origin Mode of Administration
Orthopedic Allograft Surgical
Soft Tissue Xenograft Injectable
Cardiovascular - -
Other* - -
* Includes Dental, Ophthalmic and Urologic
© RIT, 2013
History of Implants
An overwhelming concern about disease and outcome affects life in several ways. This concern is an
outcome of any disease or an injury that can bring about alterations in human bodies. Since 1989, much
hope has come in this highly complicated stream of implants. In the present moment, a person need not
lose his natural self if he suffers the loss of one of his organs or any tissue for that matter. Due to the
radical progress made in the realm of science, this has become a thing of the past.
The Need for a Better Implant
In earlier times, the wearing of an artificial eye for instance was considered much better than having no eye
at all, due to the cosmetic change it brought to the wearer. The wearing of the artificial eye was
cumbersome for the person sporting the same and it did not give a natural appearance because it did not
have movement. Thus, the first-generation implants lacked a natural appearance.
The first-generation implants suffered a lacuna in that the body would reject the implant or force it to
move away from its intended orbit. Then the need for establishing a better orbital implant arose, making it
obligatory to perform further surgeries to overcome this problem.
Naturally Derived Implants
In the quest for a natural appearance scientists stumbled upon the finding of the ocean coral and were
astounded to notice the similarity it possessed with the human bone. The porous structure of some coral species
was almost identical to the bone of man. Thus the period of naturally derived implants came into being.
Scientists found that the transformation of the essential mineral in the coral was hydroxyapatite. This
mineral, they discovered, could be matched and the approximation to the human bone could be made
more realistic.
It was found that since the hydroxyapatite implants exhibited the same porous and chemical structure of
the human bone, they were accepted by the surrounding tissue. The tissues then began growing into and
around the implant giving it the same status that it afforded to the natural bone. This however was not the
case with similar porous material such as medpor or bioceramic. Medpor is actually porous polyethylene
and bioceramic is also known as aluminum oxide. So it was seen that naturally derived implants had the
property of becoming an essential part of the human body.

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After spending a number of years in introductory research, Dr. Arthur Perry was able to, finally in 1985,
perform an eye implant made of hydroxyapatite. This could be declared as the first orbital implant ever to
be made from this mineral. The movement of the implanted eye was almost similar to the natural eye
because the eye muscles were attached to it.
Researchers gradually improved on this eye implant and it was even possible to imbue the artificial eye
with the subtle darting movements that are noticed in the natural eye. This was achieved by fitting the
artificial eye over the tissues that encase the implant. To endow the artificial eye with a more natural
appearance a titanium peg could be used to facilitate enhanced movement.
Through all these efforts it was possible to obtain a more natural-appearing artificial eye which could not
be easily differentiated by an unsuspecting observer.

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Global Market Analysis
Market Analysis of Tissue/Muscle Biological Implants by Geographic Region
Registering a CAGR of XX.XX% during the analysis period, the global orthopedic biological implants market
is projected to be worth US$ XX.XX billion by 2020. The market was estimated at US$ XX.XX billion in 2012.
With an estimated market share of about XX.XX % in 2012, North America represents the largest market for
orthopedic Biological Implants with a market worth US$ XX.XX billion. North America is projected to reach
US$ XX.XX billion by 2020 by growing at a CAGR of XX.XX % during 2005-2020 to retain the leadership.
Europe is expected to be the fastest growing as well as the second largest market with a market share of
XX.XX % in 2012, while Asia-Pacific represents second fastest growing market with CAGR of XX.XX %.
Exhibit 2. Orthopedic Biological Implants – Global Value Market Estimations and Predictions (2005-2020)
in US$ Million for North America, Europe, Asia-Pacific, and Rest of World
Year /Region North America Europe Asia-Pacific Rest of World Total
2005 XX.XX XX.XX XX.XX XX.XX XX.XX
2006 XX.XX XX.XX XX.XX XX.XX XX.XX
2007 XX.XX XX.XX XX.XX XX.XX XX.XX
2008 XX.XX XX.XX XX.XX XX.XX XX.XX
2009 XX.XX XX.XX XX.XX XX.XX XX.XX
2010 XX.XX XX.XX XX.XX XX.XX XX.XX
2011 XX.XX XX.XX XX.XX XX.XX XX.XX
2012 XX.XX XX.XX XX.XX XX.XX XX.XX
2013 XX.XX XX.XX XX.XX XX.XX XX.XX
2014 XX.XX XX.XX XX.XX XX.XX XX.XX
2015 XX.XX XX.XX XX.XX XX.XX XX.XX
2016 XX.XX XX.XX XX.XX XX.XX XX.XX
2017 XX.XX XX.XX XX.XX XX.XX XX.XX
2018 XX.XX XX.XX XX.XX XX.XX XX.XX
2019 XX.XX XX.XX XX.XX XX.XX XX.XX
2020 XX.XX XX.XX XX.XX XX.XX XX.XX
CAGR% XX.XX XX.XX XX.XX XX.XX XX.XX
© RIT Figures, 2013
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million
North America Europe Asia-Pacific Rest of World

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Exhibit 3. List of Major Global Companies
S. No Company Region Website
1 Aastrom Biosciences, Inc. USA www.aastrom.com
2 Alphatec Spine, Inc. USA www.alphatecspine.com
3 CONMED Linvatec USA www.conmed.com
4 CryoLife, Inc. USA www.cryolife.com
5 Curis, Inc. USA www.curis.com
6 Exactech, Inc. USA www.exac.com
7 Fascia Biosystems LLC USA www.fascian.com
8 Inamed Aesthetics USA www.inamed.com
9 IOP, Inc. USA www.iopinc.com
10 Integra Lifescience Corporation USA www.integra-ls.com
11 LifeCell Corporation USA www.lifecell.com
12 NuVasive Inc. USA www.nuvasive.com
13 Organogenesis, Inc. USA www.organogenesis.com
14 Osteotech, Inc. USA www.osteotech.com
15 Pegasus Biologics, Inc. USA www.pegasusbio.com
16 Stryker Corporation USA www.stryker.com
17 Tutogen Medical, Inc. USA www.tutogen.com
More….
© RIT, 2013

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III. MARKET DYNAMICS
Market Overview
Biological Implants are gaining importance in the market. Extensive research is being carried out to improve
the already existing Biological Implants and also to develop various other biological sources which can be
used as Biological Implants.
The technology in medical science is rapidly growing. Earlier, Biological Implants were considered to be the
last option. Nowadays, bone grafts and soft tissue Biological Implants have become very common. With the
advancement in tissue engineering and stem cell research, development of Biological Implants has become
much easier.
Global Market Analysis for Biological Implants
Growing at a CAGR of XX.XX% for the period 2005 through 2020, North American Biological Implants
market is projected to reach about US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012.
European Biological Implants market is projected to reach US$ XX.XX billion by 2020 from an estimated US$
XX.XX million in 2012. European Biological Implants market share is estimated at almost XX.XX % by 2020.
Asia-Pacific has the highest CAGR of XX.XX % for the period 2005 through 2020 and the market is projected
to reach US$ XX.XX billion by 2020.

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Exhibit 4. Biological Implants– Global Value Market Estimations & Predictions (2005 -2020) by Geographic
Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million
Year /Region North America Europe Asia-Pacific Rest of World Total
2005 XX.XX XX.XX XX.XX XX.XX XX.XX
2006 XX.XX XX.XX XX.XX XX.XX XX.XX
2007 XX.XX XX.XX XX.XX XX.XX XX.XX
2008 XX.XX XX.XX XX.XX XX.XX XX.XX
2009 XX.XX XX.XX XX.XX XX.XX XX.XX
2010 XX.XX XX.XX XX.XX XX.XX XX.XX
2011 XX.XX XX.XX XX.XX XX.XX XX.XX
2012 XX.XX XX.XX XX.XX XX.XX XX.XX
2013 XX.XX XX.XX XX.XX XX.XX XX.XX
2014 XX.XX XX.XX XX.XX XX.XX XX.XX
2015 XX.XX XX.XX XX.XX XX.XX XX.XX
2016 XX.XX XX.XX XX.XX XX.XX XX.XX
2017 XX.XX XX.XX XX.XX XX.XX XX.XX
2018 XX.XX XX.XX XX.XX XX.XX XX.XX
2019 XX.XX XX.XX XX.XX XX.XX XX.XX
2020 XX.XX XX.XX XX.XX XX.XX XX.XX
CAGR% XX.XX XX.XX XX.XX XX.XX XX.XX
© RIT Figures, 2013
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million
North America Europe Asia-Pacific Rest of World

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IV. PRODUCT/TECHNOLOGY RESEARCH
Cosmetic Surgery
Global Market Analysis for Cosmetic Surgery
Global Market for Cosmetic Surgery is projected at US$ XX.XX billion by 2020 from US$ XX.XX billion in 2012
with a CAGR of XX.XX % for the analysis period 2005 – 2020.
The US is the largest market for cosmetic surgery with a market value of US$ XX.XX billion in 2020 with a
market share of XX.XX % globally. Europe is the second largest market with market share of almost XX.XX %
in 2010. Rest of World is estimated to have the highest CAGR of XX.XX % and closely followed by Asia-
Pacific for the analysis period of 2005 – 2020.
Exhibit 5. Cosmetic Surgery – Global Value Market Estimations & Predictions (2005 – 2020) in US$ Billion
Year Value
2005 XX.XX
2006 XX.XX
2007 XX.XX
2008 XX.XX
2009 XX.XX
2010 XX.XX
2011 XX.XX
2012 XX.XX
2013 XX.XX
2014 XX.XX
2015 XX.XX
2016 XX.XX
2017 XX.XX
2018 XX.XX
2019 XX.XX
2020 XX.XX
CAGR% XX.XX
© RIT Figures, 2013
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Billion

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Orthopedic Biological Implants
Bone Graft Substitutes
S. No Substitute Remark
1 Autologous Growth Factor (AGF) used in
combination with autograft & ceramic graft
extender.
Safe when used as a graft extender in lumbar fusions.
2 Small pilot Randomized Controlled Trial (RCT)
comparing rhBMP-2 (bone morphogenetic
protein) to autograft for posterolateral
fusion.
rhBMP-2 used in combination with HA-TCP (V hydroxyapatite
- tricalcium phosphate) results in higher fusion rates than
autograft. rhBMP-2 may be used as a bone graft substitute
3 Multicenter RCT comparing rhBMP-2 with
autograft in anterior lumbar interbody fusion
(ALIF) with specific (LT) cage.
rhBMP-2 is a viable alternative to autograft for ALIF with
titanium cages
4 Interbody fusions using b2-TCP
(supplemented with venous blood only)
combined with structural autograft. Fusion
considered present in all cases.
β2-TCP may be used as a bone graft substitute in
combination with structural allograft & an interbody
application of venous blood.
5 Combined analysis of several series
comparing rhBMP-2 with autograft for ALIF
with specific (LT) cage.
rhBMP-2 is a viable alternative to autograft for ALIF with
titanium cages.
6 RCT comparing 3 groups treated with
noninstrumented PLF using various mixtures
of local autograft & apatite and wollanosite
(AWGC)
AWGC acts as an effective bone graft extender when used
with local autograft.
© RIT, 2013
BIOLOGICAL IMPLANTS – MARKET OUTLOOK
Global Biological Implants market is projected to grow at XX.XX% compounded annually from 2005 through
2020. This growth would be initiated especially by integration of Biological Implants into clinical trials.
Biological Implants are expected to increase productivity by identifying potential biological substitutes for
the body’s repairable parts.
North America, the leading market (XX.XX % of global market share in 2010) for Biological Implants
presently is projected to manage the leading position throughout the analysis period with its share
dropping to XX.XX % by 2020. Due to the cost advantage and access to the latest technology, Europe is the
fastest growing (XX.XX % during 2005-2020) market for Biological Implants which is closely followed by
Asia-Pacific. Europe and Asia-Pacific are expected to gain market shares while North America may lose
market dominance…………………………

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About RI Technologies
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 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
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