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Mindset Investor Presentation

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Mindset Investor Presentation

  1. 1. Leader in developing optimized psychedelic inspired medicines January 2022
  2. 2. Disclaimer The information contained in this presentation does not constitute medical advice and is not to be used for treatment purposes, or replace consultation with a qualified medical professional. The information presented here is not intended to diagnose health problems or to take the place of professional medical care. The information contained herein is neither intended to dictate what constitutes reasonable, appropriate or best care for any given health issue, nor is it intended to be used as a substitute for the independent judgment of a physician for any given health issue. All content, including text, graphics, images and information, contained on or available through this website is for general information purposes only. Opinions and estimates offered constitute our judgment and are subject to change without notice, as are statements of financial market trends, which are based on current market conditions. We believe the information provided here is reliable, but do not warrant its accuracy or completeness. This material is not intended as an offer or solicitation for the purchase or sale of any financial instrument. The views and strategies described herein may not be suitable for all investors. This material has been prepared for informational purposes only, and is not intended to provide, and should not be relied on for, accounting, legal, tax advice, or investment matters and the reader is advised and encouraged to consult their own professional advisers for confirmation of the fact and to seek contrary opinions. References to any future returns, market or share growth, future offerings or future Company performances that an individual achieves are not promises or implied. Mindset along with any of its affiliates or subsidiaries, does not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Any discussion or forecast contained herein of past or proposed outcomes are for illustrative purposes only and should not be relied upon as any indication of future outcomes of industry trends, financial, development, executional or growth performance. This presentation of Mindset contains “forward-looking information”, which may include, but is not limited to, statements with respect to anticipated business plans or strategies of Mindset, the listing of Mindset’s common shares on the Canadian Securities Exchange, the anticipated completion of clinical studies, the timing of any drug trials, the success of its pre-clinical and clinical trials, the ability to enter into acquisitions or collaborations to enhance its drug development platform, the success of any such acquisitions or collaborations and the ability to use the information relating to, or obtain patents or other intellectual property protection on, data and clinical trials generated directly by Mindset or through such acquisitions or collaborations, and the success or stage of development of discoveries or medicines. Often, but not always, forward-looking statements can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, "intends", "anticipates", or "believes" or variations (including negative variations) of such words and phrases, or state that certain actions, events or results "may", "could", "would", "might" or "will" be taken, occur or be achieved. Forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Mindset to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, dependence on obtaining and maintaining regulatory approvals, including acquiring and renewing federal, provincial, municipal, local or other licenses and any inability to obtain all necessary governmental approvals licenses and permits to operate and expand the Company’s facilities; engaging in activities which currently are illegal under Canadian federal law and the uncertainty of existing protection from Canadian federal or other prosecution; regulatory or political change such as changes in applicable laws and regulations, including federal and provincial legalization, due to inconsistent public opinion, perception of the use of psychedelic therapies, bureaucratic delays or inefficiencies or any other reasons; any other factors or developments which may hinder market growth; the Company’s limited operating history and lack of historical profits; reliance on management; the Company’s requirements for additional financing, and the effect of capital market conditions and other factors on capital availability; competition, including from more established or better financed competitors; and the need to secure and maintain corporate alliances and partnerships, including with customers and suppliers. The foregoing factors are not intended to be exhaustive. Although Mindset has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events or results to differ from those anticipated, estimate or intended. Forward-looking statements contained herein are made as of the date of this presentation and Mindset disclaims, other than as required by law, any obligation to update any forward-looking statements whether as a result of new information, results, future events, circumstances, or if management's estimates or opinions should change, or otherwise. There can be no assurance that forward-looking statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, the listener is cautioned not to place undue reliance on forward-looking statements. Forward Looking Statements 2
  3. 3. CSE: MSET OTCQB: MSSTF 3 About Us Mindset is developing superior psychedelic medications to better meet the needs of patients First mover IP advantage, advancing 4 families of novel, optimized, drugs to the clinic Groundbreaking partnership with Otsuka Pharmaceutical – top global neuroscience pharma – to accelerate commercialization of multiple new drug families The leading drug discovery platform of the medical psychedelic space, led by accomplished drug discovery scientists
  4. 4. CSE: MSET OTCQB: MSSTF 4 Market Opportunity Psychedelic drugs address multiple indications affecting large population groups (e.g. ~ 280 M people suffer from depression worldwide*) Current psychedelic drugs can and should be improved: Safety Duration / Predictability “Nature” of trip Current psychedelic drugs not patentable Developing new drugs that meet these criteria will be an enormous opportunity for patients and investors *World Health Organization website
  5. 5. CSE: MSET OTCQB: MSSTF 5 Comprehensive IP coverage 8 patent applications filed covering a broad range of novel, next generation drugs inspired by psilocybin, DMT, & 5-MeO-DMT, as well as a novel psilocybin synthesis method Broad pipeline of differentiated drug candidates Over 100 new chemical entities screened Lead compound MSP-1014 identified for clinical development for mood disorders; demonstrated superior preclinical efficacy and safety to psilocybin Strong signals of favorable differentiation across portfolio compared to first generation drugs in safety, effect size, and duration Leading Drug Discovery Platform Strong progress towards commercialization Development collaboration with the McQuade Center for Strategic Research and Development, LLC (“MSRD”), a member of the global Otsuka family of pharmaceutical companies Opportunity for additional partnership agreements
  6. 6. Mindset entered into a partnership with the R&D arm of Otsuka Pharmaceutical, a global leader in bringing CNS medications to market Highlights include: • All development expenses paid for exclusively by Otsuka for Family 2 & 4 drugs through the completion of phase 1B (anticipated to be within 12-18 months) o Total cost of developing multiple families through phase 1B may be up to US$45M1 • US$5M cash payment + potential milestone payments • ALL FUNDING NON-DILUTIVE in exchange for ROFN & ROFR on Family 2 & 4 drugs • Extensive operational support provided by Otsuka, eliminating significant future G&A costs by Mindset • Following completion of the collaboration, Mindset will potentially own multiple Phase 2 ready drug candidates with the ability to negotiate an additional transaction with Otsuka Mindset is the first and only group to partner with big pharma on new psychedelic drugs: partnership de-risks and validates Mindset programs 6 F i r s t B i g P h a r m a p a r t n e r s h i p f o c u s e d o n N e w D r u g s 1. Office of Health Economics, The R&D Cost of a New Medicine.
  7. 7. CSE: MSET OTCQB: MSSTF 7 Macrodosing Microdosing • Psilocybin analog – potential 505(b)2 pathway drug. • Similar 5-HT2A receptor binding and functional profile to psilocybin. • CNS penetrant and orally active. #1 Family • Improved 5-HT2A receptor functional profile. • CNS penetrant and orally active. • Potentially shorter acting. #2 Family • Unique serotonergic receptor profile. • Short duration. • Distinct behavioural pattern. #4 Family • Similar 5-HT2A receptor binding and reduced functional profile to psilocybin. • Long duration of effect. #3 Family PSILOCYBIN-INSPIRED PSILOCYBIN-INSPIRED DMT/5-MeO-DMT-INSPIRED PSILOCYBIN-INSPIRED A platform technology applicable to the entire psychedelic field Mindset Portfolio Overview
  8. 8. CSE: MSET OTCQB: MSSTF 8 MSP-1014 (Family #1) MSP-1014 is a new chemical entity that incorporates a conjugated amplifier into a psilocybin-like structure to create a more powerful, effective drug: Stronger 5-HT2A activity than psilocybin and attenuated reduction in locomotor activity Consistent body temperature at higher doses indicates potentially greater safety profile than psilocybin Simpler and more cost-effective manufacturing Not a scheduled substance based on current Health Canada guidance MSP-1014 has the potential to be a stronger, safer, more cost-effective alternative to psilocybin
  9. 9. CSE: MSET OTCQB: MSSTF Compound ID# Half-life (t1/2, min) Human Rat Mouse Psi Reference 117 89 142 MSP-3002 1317 119 ∞ 9 Family #3 Long-acting next generation psychedelic drug positioned for microdosing. MSP-3002 Similar binding profile to psilocybin Lower potency and long half life CNS penetrant Ideal for microdosing Family 3 has an ideal once-a-day microdosing profile Human 5-HT2A (Radioligand Binding Assay) MSP-3002: In vitro ADME -10 -9 -8 -7 -6 -5 100 200 300 400 500 5-HT2A (Agonist Screening-FLIPR Assay) Log[Agonist], M RFU MSP-1001 (Psi) MSP-3007 MSP-3002
  10. 10. 1 0 CSE: MSET OTCQB: MSSTF Family / Product Lead Identification Lead Optimization IND-Enabling Clinical Phase 1 Clinical Indication / Phase 1 Timing M i n d s e t R & D P i p e l i n e Family#1 MSP-1014 TR Depression & Terminal Cancer Angst Family#2 Family#4 Family#3 Undisclosed Targets 10 Partnered Indications related to cognitive / attentional impairments; TBD TBD
  11. 11. 1 1 CSE: MSET OTCQB: MSSTF Upcoming Milestones Accelerate development of Families 2 & 4 via collaboration with Otsuka’s MSRD Announce platform technology Expand IP portfolio into new classes of psychedelic drugs Commence Phase 1 clinical trials in 2022 for MSP-1014 11
  12. 12. CSE: MSET OTCQB: MSSTF 12 Joseph Araujo President and CEO of InterVivo Solutions, a specialized CRO focused on optimizing translational services to facilitate the development of CNS drugs. More than 35 refereed publications and several invited presentations, which focus on natural aged canine models of human disease. Has co-founded, held executive positions and consulted for Life Science companies including CanCog Technologies, Vivocore, Karyopharm Therapeutics, NPM Pharma and Ketogen. Has conducted extensive research examining psychoactive drugs. CHIEF SCIENCE OFFICER AND DIRECTOR
  13. 13. CSE: MSET OTCQB: MSSTF 13 Malik Slassi, Ph.D Founder, President & Chief Scientific Officer of Fluorinov Pharma Inc. acquired by Trillium in January 2016. Former Senior Vice President of Discovery Research at Trillium Therapeutics Inc. and Vice President of Medicinal Chemistry, Manufacturing & Development at Cascade Therapeutics, and earlier Dr. Slassi held management & scientific positions at Allelix Biopharmaceuticals, Bio-Mega/Boehringer Ingelheim Research and NPS Pharmaceuticals. Involved in multinational R&D collaborations with Hoechst AG (Sanofi-Aventis), AstraZeneca, Johnson & Johnson, Forest Laboratories, GlaxoSmithKline, Memory and Shire Pharmaceuticals. 30+ years of experience in successful identification & development of small molecule drug candidates across multiple therapeutic areas, including CNS. 24+ drugs advanced into late-stage preclinical, clinical development & market; co-authored 65+ research papers & review articles, and is an inventor of 130+ issued patents and patent applications. Holds a Ph.D. in chemistry from the University of Claude Bernard, Lyon, France and completed his postdoctoral work in the Chemistry Department at the University of Montreal, Canada. SENIOR VICE PRESIDENT OF INNOVATION
  14. 14. CSE: MSET OTCQB: MSSTF 14 Joseph Gabriele, Ph.D. Scientific Advisor Guy Higgins, Ph.D. Scientific Advisor Michael Rogawski, M.D., Ph.D. Scientific Advisor James Lanthier Chief Executive Officer Jason Atkinson Corporate Development Richard Patricio Chairman James Passin Director Philip Williams Director Ishrat Husain, M.D. Scientific Advisor Ian Dean Director, Preclinical Ali Kandil, Ph.D. CMC Consultant
  15. 15. CSE: MSET OTCQB: MSSTF 15 Capital Structure. Shares Outstanding 90.4mm Dilutable Securities 45.4mm Weighted Avg Exercise Prices $0.65 Fully Diluted Shares 132.7mm
  16. 16. CSE: MSET OTCQB: MSSTF 16 Thank you For further information please visit: www.mindsetpharma.com

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