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Epigenetics

Define epigenetics.
Describe important epigenetic mechanism and explain the implication of epigenetics in normal functions, disease and disease presentation.
Outline the heritability or epigenetic effects.
Explain the role of epigenetic in the development of cancer.
Outline the potentials of epigenetic intervention in battling cancer.

Speaker,
Dr. Md. Mohiuddin Masum
MS Anatomy, Phase-A, Year-1, Block-1

Guided by,
Prof. K M Shamim
Professor, Dept. of Anatomy, BSMMU

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Epigenetics

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  3. 3. “ What beyond Genetics is playing here?
  4. 4. Epigenetics: Basic Concept and Its Relationship with Development and Cancer Speaker, Dr. Md. Mohiuddin Masum MS Anatomy, Phase-A, Year-1, Block-1 Guided by, Prof. K M Shamim Professor, Dept. of Anatomy, BSMMU
  5. 5. “ • Define epigenetics • Describe important epigenetic mechanism and explain the implication of epigenetics in normal functions, disease and disease presentation Objective
  6. 6. “ • Outline the heritability or epigenetic effects • Explain the role of epigenetic in the development of cancer • Outline the potentials of epigenetic intervention in battling cancer Objective (contd.)
  7. 7. Epigenetics Epi + Genetics Heritable changes in gene expression that operate outside of changes in DNA itself
  8. 8. Chromosome Structure Purines Pyrimidines
  9. 9. Chromosome Structure (contd.)
  10. 10. DNA Methylation
  11. 11. Histone Modification ac me P ub acclt Acetylation Methylation Phosphorylation Ubiquination Deimination
  12. 12. microRNA
  13. 13. Genetics Environment Behavior Nutrition
  14. 14. Inactivation of X-chromosome Barr Body
  15. 15. Differention of Pluripotent Stem Cells to Somatic Cells
  16. 16. Genomic Imprinting Working set Imprinted set (and thus silenced) Working set Imprinted set (and thus silenced) Combination- 1 Combination- 2 Normal Non-working set Imprinted set (and thus silenced) Non-working set Imprinted set (and thus silenced) Father’s gene is imprinted (silenced) Mothers gene is mutated (non-working) Mother’s gene is imprinted (silenced) Father’s gene is mutated (non-working) Prader-Wili syndrome Angelman syndrome ♀ ♂ ♀♂ ♀ ♂ ♀ ♂
  17. 17. Mother: 1st Generation Fetus: 2nd Generation Germ cells: 3rd Generation
  18. 18. Epigenetics Genetics
  19. 19. Battling Cancer Using Epigenetics
  20. 20. Battling Cancer Using Epigenetics

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