Explore how stem cell therapy is emerging as a potential breakthrough in the treatment of peripheral artery disease (PAD). This ppt by Dr David Greene r3 stem cell will delve into the science behind stem cells, their regenerative properties, and how they can be utilized to improve blood flow, promote angiogenesis, and potentially restore damaged tissues in PAD patients.

1. STEM CELL THERAPY'S
ROLE IN MANAGING
PERIPHERAL ARTERY
DISEASE
Dr. David Greene R3 Stem Cell

2. INTRODUCTION
• Peripheral Artery Disease (PAD) defined as
the narrowing or blockage of blood vessels in
the legs, arms, stomach, or kidneys.
• PAD affects millions of people worldwide,
leading to reduced blood flow, pain, and
tissue damage.
• Stem cell therapy emerges as a promising
approach for managing PAD.

3. UNDERSTANDING STEM
CELL THERAPY
• Stem cells are undifferentiated cells capable
of self-renewal and differentiation into
specialized cell types.
• Two main sources of stem cells: embryonic
stem cells and adult stem cells.
• Adult stem cells, such as mesenchymal stem
cells (MSCs), can be harvested from various
tissues, including bone marrow and adipose
tissue.

4. MECHANISM OF ACTION
• Stem cell therapy in PAD aims to enhance
blood vessel formation and promote tissue
regeneration.
• MSCs possess angiogenic and
immunomodulatory properties.
• MSCs can differentiate into endothelial cells
and smooth muscle cells, contributing to
blood vessel repair and remodeling.

5. BENEFITS
Benefits of stem cell therapy in PAD:
• Improved blood flow and pain relief.
• Reduced need for amputation.
• Potential for long-term tissue
regeneration.

6. FUTURE DIRECTIONS
• Combination therapies, such as combining
stem cells with growth factors or gene
therapy, show promise.
• Advances in tissue engineering and 3D
printing may allow for the creation of
personalized vascular grafts.

7. CONCLUSION
• Stem cell therapy holds great potential in
managing peripheral artery disease.
• Stem cell therapy has also shown the ability
to reduce inflammation and promote tissue
healing.

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9. THANK YOU