25. COMPARISON CIMETIDINE RANITIDINE CHEMISTRY IMIDAZOLE DERIVATIVE FURAN DERIVATIVE BIO – AVAILABLILITY 80 % 52 % PLASMA PROTEIN BINDING 20 % 15 % T ½ 2 HRS 2 HRS CROSSING OF B B B POOR VERY POOR DURATION OF ACTION SHORT LONG
26. POTENCY LESS 5 TIMES MORE THAN CIMETIDINE DOSE 800 mg 300 mg BINDING WITH CYT – P 450 PRESENT NEGLIGIBLE DRUG – INTERACTION INTERFERES WITH HEPATIC METABOLISM OF DRUGS NEGLIGIBLE TOXICITY CNS ENDOCRINOL-OGICAL HEPATIC NOT SEEN
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