Arka kalpana and its modern aspect.pptx

Dr Priyanka Patil
Dr Priyanka PatilDoctor em RKM ayurvedic medical college, Vijayapura
By
Dr.Priyanka Patil
MD(Ayu)
DeptofRS & BK
Introduction
• Bhaishajya kalpana is the branch of ayurveda, which
primarily deals with the different kinds of dosage
forms and their therapeutic utility.
• Arka kalpana is described as one among the
panchavidha kashaya kalpana by Lankapati ravana in
his text arka prakasha.
• The word arka is derived from ‘Ru-gatau’. Every
word contains meaning. Gati(motion) denotes three
meanings i.e. Gyan, gamana and prapti.
• The knowledge of the contents of the drug is first thing (i.e.
Gyan), then the motion is given to the contents through water
(i.e. Gamana) and lastly reqquired amount of active content is
obtained(i.e. Prapti). Thus, arka caontains the complete
aspect of its manufacturing process by root word ‘Ru-gatau’.
• some of the drugs contain active principles in the form of
volatile oil hence by using these drugs if kwatha is prepared
,while doing preparation itself active ingredients may get
evapourated .Arka kalpana is prepared with such drugs. For
eg.gulabi pushpa,pudina etc.
• Yunani system of medication uses such medications in larger
scale .
• From 18th century onwards these preparations were widely
adopted in books of ayurveda
Literature review
kaala descrition
Samhita kala References are not avilable
Adhunika kala : Gada nigraha Asava
arista vignana, sahasrayoga
In Kharjurasava an equipment similar to arka
yantra and preparation of Arka from asava is
mentioned
Ayurvedic Formulary of India The definition, method of preparation,
characteristics and examples of Arkas are
mentioned in both the volumes
Rasatantra sara and siddha Prayoga
sangraha
Examples of 21 arkas are mentioned in the first
volume. In this book the practical experiences of
the author is also mentioned along with dose.
Bharateeya bhaishajya kalpana Synonyms, history, method of preparation,
precautions, samyak lakshana and eight different
examples of arka kalpana
In Arka Prakasha, different ratios for distilling,
reference for 196 single drugs and 192 aushada
yogas for preparation of Arka with their
indication is described with details about Varuni
Yantra for preparation of Arka.
Different names
• Ayurveda : Arka
• Unani : Arkquites
• Siddha : Tineer
• Hmeopathy : Tincture
• Allopathy : distillate
Importance of arka kalpana
• Compared to the pancha vidha kashaya kalpana it can be
preserved for longer duration.
• Possess good palatability and attractive colour
• It is the more sterile method compared to other preparations.
• As it is liquid dosage form it is having faster absorption than
solid dosage forms
• The yield during kashaya preparation is only 1/4th of the water
taken. But in Arka, it is about 3/4th of initial water.
• In the economic view point, Arka can be prepared much
cheaper than that of a kashaya.
Definition
• Arka kalpana can be defined as a liquid preparation
obtained by distillation of certain liquids or of drugs
soaked in water using the arka yantra or any
convenient modern distillation apparatus.
Classification of arka
According to contents :
• Sthira arka: non volatile drug extraction e.g.triphala
• Gandha arka: fragrant or volatile oil extraction
• Drava arka: liquid – liquid extraction e.g. gomutra
According to duration of preparation :
• Nyuna arka : 3 hrs
• Madhyama arka : 6 hrs
• Shreshta arka : 9hr
According to part used :
• pushpa arka
• Sattu dhanya arka
• Kshiri vruksha arka
• Visha varga arka
• Taila dhanya arka
• Sugandha gana arka
• Tandul arka
Procedure
• Arka is prepared by the process of distillation
of water soaked raw drugs with help of
Distillation apparatus (Arka Yantra).
• The volatile constituents which are evolved,
admixture with water vapour. Then, they are
condensed and collected.
Procedure
• Distillation apparatus consists of three parts:
1. Still
2. Condenser
3. Receiver
Procedure
• The still consists of a basal receptacle to contain the
drugs, and a cover with an exhaust tube which is
conveniently bent to drain the distillate into the bottle.
• A copular reservoir is provided at the region where the
exhaust leaves the lid portion.
• The receptacle of the retort may be an earthen pot or
preferably a metallic one. When made of metals like
brass or copper, the interior should be tin coated.
Procedure
• Iron should not be used because it gets rusted
and corroded in a short period.
• Stainless steel stills are excellent for this
purpose.
• It is advisable to provide a perforated false
bottom in the receptacle to keep the drug
intended for extraction and to avoid charring.
Procedure
• The copular reservoir over the lid is filled with
cold water during distillation and it serve as a
sort of crude type of condenser.
• This crude device could be replaced by a good
condenser in the form of a water jacket
around the exhaust tube, or even a spiral type
of condenser could be provided.
Methode of preparation
Coarsely powdered drug + prescribed quantity of water
soak drug overnight + drug turns soft
transfer to arka yantra and boil
vapour is condensed
distillate is collected in receiver
End of the process
• The end of the process of Arka preparation is
marked by the escape of dark fumes from the
exhaust. Further attempts to heat and collect
the remnants of condensate should not be
made once this phenomenon is noticed.
• Usually the volume of the distillate is 3/4th of
the total volume of the drug and water
mixture taken for distillation.
Final product
• Thus produced Arka is a suspension of the
distillate in water having slight turbidity.
• Depending upon the nature of the crude drugs
under going for the distillation, the Arka will
have characteristic colour and odour.
Precautions
• While doing Arka preparation, distillation apparatus
should be exposed with Mandagni, because boiling of
the drugs with excessive heat will lead to water getting
vaporized early. There by spoiled kwatha like
preparation will be produced.
• Because of more heat, very soon the water content will
get vaporized and there is a chance of burning and
spoilage of arka dravya, then little bit arka is produced
which contains improper taste, smell and which will
not be up to mark.
Precautions
• The lid should be tightly placed and sealed
around to prevent vapors from escaping.
• Heat is applied to the drug mixture and the
distillate is collected in large bottles and mixed
well to ensure uniform concentration of the
medicine because the first distillate is much
concentrated compared to that collected at the
end of the process when the drugs are depleted
of the medicinal principles.
Precautions
• Continuous water current should be maintained
in the condenser.
• When a copular type of condenser is used, water
is replaced by cool water when it becomes
warmed up.
• The vessel or bottle in which the distillate is
collected is placed in a container containing cold
water.
Shad Agnis in preparation of Arka
kalpana
Sl. no. Type of agni Total time
taken
Quantity of fuel feature
1 dhumagni 2 yama Not mentioned Wihtout any flame if
there is huge amount
of fume
2 deepagni 1 ½ yama 2 Part of the
quarter of
mushti
If the flame of
dhumagni is
increasesed to 2 or 4
times
3 mandagni 1 yama Quarter of one
mushti
If the flame of dipagni
is again increased to 4
times
4 madhyamagni Between diptagni
and mandagni
½ mushti The agni in which the
flame is in between
dipagni and mandagni
5 kharagni 1 muhurtha 2 ½ mushti Fifth part more than
that of madhayamagni
is kharagni, this agni is
used for all purposes
6 Bhatagni 1 muhurtha Not
mentioned
The agni in which the
flame spreads all over
the bottom
Different methods of preparation of arkas
Type of drug quantity of water exmples
Atyanta khatina 3 parts chandana
khatina 2 parts ajamoda
Sarasa nala 20 part Nirgundi, eranda
patra 100 part vasa
nirasa 20 part Vata, ashwatha
Mridu dugdhika 4 parts Dugdhika
Tikshna dugdhika 10 parts satala
phala not added Amra
Kashta oushadas 80 parts of water, udumbara
Atipakwa phala not added kadali
pushpa 16 parts Gulab arka
Katu phala 40 parts pippali
Drava dravya not added Gomutra
Prashasta Arka Lakshana
SìurÉÉSÍkÉMüxÉÉæaÉlkrÉÇ rÉÎxqɳÉMåïü mÉëSÛzrÉiÉå |
eÉÏhÉÉïÎxjÉmÉɧÉxÉÇͤÉmiÉÉå SìurÉuÉhÉï: mÉëSÛzrÉiÉå ||
zÉÇZÉMÑülSålSÒkÉuÉsÉÉåÅlrÉjÉÉmÉɧÉÉliÉUÎxjÉiÉ: |
ÎeÉÀûÉåmÉËUaÉiÉ: xuÉÉSÇ S±ÉSèSìurÉpÉuÉÇ iÉÑ rÉç:
||(A.mÉë.1/74-75)
• Clear and transparent
• Must have taste of ingredients
• It must comprehend the odour of ingredients
• It must have the same colour of drugs if kept in
jeernasthimrithika patra
• If kept in other vessels it should have the colour of shanka and
chandra
QUALITIES OF AN ARKA UNFIT FOR
THERAPEUTIC USE :
aÉÑhÉÉrÉ mɶÉÉixÉåuÉåiÉ iuÉlrÉjÉÉÅmÉaÉÑhÉÉå pÉuÉåiÉ |
SÒaÉïlkÉÇ pɤÉrÉåSMïü rÉÌS qÉÉåWûÉiMüjÉgcÉlÉ ||
iÉSÉÅxrÉ eÉÉrÉiÉå asÉÉÌlÉuÉÉïliÉqÉÉsÉxrÉMÇü iÉjÉÉ |
iɬÉåwÉxrÉ ÌuÉlÉÉzÉÉrÉ MÑürÉï²ÉÎliÉqÉiÉÎlSìiÉ:
||(A.mÉë.1/77-78)
• Unpleasant odour
• If it causes giddiness
• If it is turbid
• If taste colour etc… have changed.
NATURE OF THE VESSEL FOR STORAGE OF
ARKA
eÉÏhÉÉïÎxjÉmÉɧÉå aÉÚ̺ûrÉÉSMïÇ uÉÉ
MüÉcÉxÉqpÉuÉå |
mÉÉwÉÉhÉMåüÅjÉuÉÉ mÉɧÉå ApÉÉuÉå qÉÚlqÉrÉå
lrÉxÉåiÉç || (Aç.mÉë 1/87)
• Jeernasthimrithika patra
• Glass
• Stone
• Clay
Mode of administration of arka
• Pana-Shopha :
punarnava+satala+haridra+kumarika
• Swedana - Shopha ‘’
• Nasya - lasuna arka,aromatherapy
• Gandusha - Dantaroga : nila +katu+kakajangha
• Anjana - sitamanashiladi anjana
• External application - Gulab arka
What should be done after consumption of
arka
• ÌmÉoÉåSMïüqÉÌlÉuÉÉïrÉïÇ mÉÏiuÉÉ iÉÉqoÉÑsÉpɤÉhÉqÉç |
MÑürÉÉïSpÉÑ£üiÉÉqoÉÑsÉÉå sÉuÉÇaÉÇ pɤÉrÉå¨ÉÑ cÉ
||(A.mÉë.1/88)
• In arka prakasha it is mentioned that after taking of arka,
Tambula or Lavana sevana should be done.
Shelf life / Expiry date:
• 1 year from the date of manufacturing
(Rule 161-B of D&C Act)
Dose:
• API: 10 to 20 ml per day in divided doses.
• AFI: 12 to 24 ml per day in divided doses.
Anupana:
• Equal amount of water
Arka and Mano Gunas
• Avartita arka is tamasika which is taken for
doing nishiddha karmas and to induce nidra. It
is liked by Pishachas
• The arka made from rice water (manda) is
rajasika. It is consumed for doing sahasa
karmas.
• All others will come under satvika. It is good
for those who are engaged in geetha hasya
karmas.
Modern View
• In modern pharmaceutics, Arka kalpana can be
compared to distillation.
• Distillation is the process of separating the constituents
of a liquid by vaporizing the liquid and passing the
vapors through a cold surface and thereby converting
the vapors again into liquid.
• There are different types of distillation which include
Simple distillation, Fractional distillation, Steam
distillation, Vacuum distillation and Destructive
distillation etc.
Simple Distillation
• It is the separation of volatile liquids from non-
volatile solids(drugs).
• It is the conversion of liquid into vapors and again
condensing vapors into liquids
• The apparatus used is simple distillation apparatus .
It consists of still, condenser and receiver.
Fractional distillation
• It is the process to separate two volatile liquids with
different boiling points
Eg: mixture of alcohol and water where alcohol is
more volatile and evaporates faster than water.
Steam distillation
• Steam distillation is a method for distilling
compounds which are heat-sensitive.
• The temperature of the steam is easier to control
than the surface of a heating element, and allows
a high rate of heat transfer without heating at a
very high temperature.
• This process involves bubbling steam through a
heated mixture of the raw material.
• Some of the target compound will vaporize. Then
vapor mixture is cooled and condensed, usually
yielding a layer of oil and a layer of water.
• Steam distillation of various aromatic herbs
and flowers can result in two products; an
essential oil as well as a watery herbal
distillate.
• The essential oils are often used in perfumery
and aromatherapy while the watery distillates
have many applications in aromatherapy, food
processing and skin care.
Vacuum distillation
• The distillation carried out under reduced pressure.
• A liquid boils when its vapor pressure becomes equal
to the atmospheric pressure
• So liquids can be boiled at a much lower temperature
than its boiling point if the pressure on the surface of
the liquid is reduced.
• Claisen flask- still for vacuum distillation
Destructive distillation
• Destructive distillation or Dry distillation , despite
the name, is not truly distillation, but rather a
chemical reaction known as pyrolysis in which
solid substances are heated in an inert or
reducing atmosphere and any volatile fractions,
containing high-boiling liquids and products of
pyrolysis, are collected.
• The destructive distillation of wood to give
methanol is the root of its common name – wood
alcohol.
Analytical parameters
1. Description
Colour
Odour
2. pH
3. Volatile matter
4. Specific gravity at 200C (generally 0.991-1.0)
5. Clarity test
6. Identifications, TLC/HPTLC/GLC
7. Assay for essential oil
8. Test for heavy metals- Pb, Cd, Hg, As
9. Microbial contamination-
Total bacterial count
Total fungal count
10. Test for specific Pathogen-
E. coli, Salmonella spp., S. aureus, Pseudomonas
aeruginosa.
11. Pesticide residue-
Organochlorine pesticides
Organophosphorus pesticides
Pyrethroids
Some examples :
Ajmoda Arka:
• Agnimandya, Ajeerna, Bastiroga, Vatakapharoga.
Brahmi Arka:
• Buddhi mandata, Smriti bhrama.
Jatamansi Arka:
• Agnimandya, Arocaka, Mukha daurgandhya,
Unmada, Apasmara.
Gulaba Arka:
• Daha, Trishna, Hrillasa, Netraroga.
Kakmachi Arka:
• Hrid roga, Yakridroga, Sotha.
Munditika Arka:
• Pleeha roga, Meha, Vataroga, Tvakroga, Arunsika.
Satahva Arka:
• Jvara, Vata Kaphaja roga, Vrana shula, Netraroga,
Agnimandya, Atisara.
Mishreya Arka:
• Mandagni, Adhmana, Shula, Krimi, Yoni shula
Parpata Arka:
• Jvara (fever), Trishna, Atisara, Daha.
Pudina Arka:
• Chardi, Ajeerna, Udara shula, Agnimandya.
Punarnava Arka:
• Jalodara, Sotha, Netraroga.
Yavani Arka:
• Trika shula, Agnimandya.
Different study’s on arka kalpana
• A study on Medovriddhi (Obesity) and its
management with Medohara Arka
• N.C. Das, Nagendra Prasad and B.K. Das,2005,
IJRAP
• Conclusion : Study reveals maximum
improvement, moderate improvement, mild
improvement and unsatisfactory being 5%, 75%,
15% and 5% respectively.
EVALUATION OF JATAMAMSI ARKA
ON ESSENTIAL HYPERTENSION
conclusion:
Jatamamsi Arka being Deepaka- Pachaka, Tridosha
hara, Medhya, Rakta dosha hara , Medohara and
Mootrala, acted over all these aspects and thus
proved effective in reducing both systolic and
diastolic pressure.
A COMPARATIVE STUDY OF ERANDAMULADI
NIRUHA BASTI WITH & WITHOUT GOMUTRA
ARKA IN THE MANAGEMENT OF VATA
KAPHAJA GHRIDHRASI
CONCLUSION:The Basti with GA group is more
potent in mitigating Vata and Kapha and also
potentiating Agni.
Antimicrobial Activities of Cow Urine
Distillate Against Some Clinical
Pathogens
• Arunkumar Sathasivam, 1 2M. Muthuselvam
and 1Rajasekaran Rajendran
• Conclusion :Maximum antibacterial activity
was observed in Pseudomonas aeruginosa
and Salmonella typhi . Antifungal activity of
cows urine distillate was analyzed against
Aspergillus niger and Aspergillus flavus.
Arka as Bio-enhancer
• Gurupreet kaur Randhava Department of
Pharmacology, Government Medical College,
Amritsar
• Conclusion: Gomutra arka enhances the
transport of antibiotics, rifampicilin,
tetracycline & ampicilin across the gut wall as
well as across artificial membranes.
• The Effect of Rose Water Inhalation on Cardiac
Parasympathetic Activity
• S. Mehran Hosseini1, Mohsen Jamshir
• In effect of 120 seconds rose water odour
inhalation parasympathetic tone (HF)
increased and heart rate (HR) and sympathetic
tone (LF/HF) decreased. Differential and direct
parasympathetic modulation may account for
part of this effect.
Discussion
• In the present era, very less people prefer
kashaya because of its palatibility. Arka is nothing
but the lost partof kashaya. So, it can be used at
the place of kashayas with better patient
compliance.
• Many Arkas are mentioned in various authentic
books of Ayurveda. They are not much popular in
the market. The reason behind it may be the lack
of knowledge about this kalpana.
• Though different modes of administration are
told,its usage is usually limited as Pana, nasya and
Anjana.
Conclusion
• Arka is the most potent preparation included
under the Panchavidha kalpanas of Ravana
• It is the most potent due to dosharahithatva and
its specific gunas. It is having increased potency,
reduced dose, more shelf life and also easy
absorption, fast action and better patient
compliance.
• Arkas can be prepared from Herbs, Minerals &
Animal origin drugs
• Arka can be used for secondary preparations
• Arka can be prepared from modern distillation
apparatus also.
• Although 505 arka preparations are mentioned
in arkaprakasa ,only few of the preparations
are used in clinical practice.
• So research works has to done on arka
preparations to bring those excellent remedies
to the main stream.
Arka kalpana and its modern aspect.pptx
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Arka kalpana and its modern aspect.pptx

  • 2. Introduction • Bhaishajya kalpana is the branch of ayurveda, which primarily deals with the different kinds of dosage forms and their therapeutic utility. • Arka kalpana is described as one among the panchavidha kashaya kalpana by Lankapati ravana in his text arka prakasha. • The word arka is derived from ‘Ru-gatau’. Every word contains meaning. Gati(motion) denotes three meanings i.e. Gyan, gamana and prapti.
  • 3. • The knowledge of the contents of the drug is first thing (i.e. Gyan), then the motion is given to the contents through water (i.e. Gamana) and lastly reqquired amount of active content is obtained(i.e. Prapti). Thus, arka caontains the complete aspect of its manufacturing process by root word ‘Ru-gatau’. • some of the drugs contain active principles in the form of volatile oil hence by using these drugs if kwatha is prepared ,while doing preparation itself active ingredients may get evapourated .Arka kalpana is prepared with such drugs. For eg.gulabi pushpa,pudina etc. • Yunani system of medication uses such medications in larger scale . • From 18th century onwards these preparations were widely adopted in books of ayurveda
  • 4. Literature review kaala descrition Samhita kala References are not avilable Adhunika kala : Gada nigraha Asava arista vignana, sahasrayoga In Kharjurasava an equipment similar to arka yantra and preparation of Arka from asava is mentioned Ayurvedic Formulary of India The definition, method of preparation, characteristics and examples of Arkas are mentioned in both the volumes Rasatantra sara and siddha Prayoga sangraha Examples of 21 arkas are mentioned in the first volume. In this book the practical experiences of the author is also mentioned along with dose. Bharateeya bhaishajya kalpana Synonyms, history, method of preparation, precautions, samyak lakshana and eight different examples of arka kalpana
  • 5. In Arka Prakasha, different ratios for distilling, reference for 196 single drugs and 192 aushada yogas for preparation of Arka with their indication is described with details about Varuni Yantra for preparation of Arka. Different names • Ayurveda : Arka • Unani : Arkquites • Siddha : Tineer • Hmeopathy : Tincture • Allopathy : distillate
  • 6. Importance of arka kalpana • Compared to the pancha vidha kashaya kalpana it can be preserved for longer duration. • Possess good palatability and attractive colour • It is the more sterile method compared to other preparations. • As it is liquid dosage form it is having faster absorption than solid dosage forms • The yield during kashaya preparation is only 1/4th of the water taken. But in Arka, it is about 3/4th of initial water. • In the economic view point, Arka can be prepared much cheaper than that of a kashaya.
  • 7. Definition • Arka kalpana can be defined as a liquid preparation obtained by distillation of certain liquids or of drugs soaked in water using the arka yantra or any convenient modern distillation apparatus. Classification of arka According to contents : • Sthira arka: non volatile drug extraction e.g.triphala • Gandha arka: fragrant or volatile oil extraction • Drava arka: liquid – liquid extraction e.g. gomutra
  • 8. According to duration of preparation : • Nyuna arka : 3 hrs • Madhyama arka : 6 hrs • Shreshta arka : 9hr According to part used : • pushpa arka • Sattu dhanya arka • Kshiri vruksha arka • Visha varga arka • Taila dhanya arka • Sugandha gana arka • Tandul arka
  • 9. Procedure • Arka is prepared by the process of distillation of water soaked raw drugs with help of Distillation apparatus (Arka Yantra). • The volatile constituents which are evolved, admixture with water vapour. Then, they are condensed and collected.
  • 10. Procedure • Distillation apparatus consists of three parts: 1. Still 2. Condenser 3. Receiver
  • 11. Procedure • The still consists of a basal receptacle to contain the drugs, and a cover with an exhaust tube which is conveniently bent to drain the distillate into the bottle. • A copular reservoir is provided at the region where the exhaust leaves the lid portion. • The receptacle of the retort may be an earthen pot or preferably a metallic one. When made of metals like brass or copper, the interior should be tin coated.
  • 12. Procedure • Iron should not be used because it gets rusted and corroded in a short period. • Stainless steel stills are excellent for this purpose. • It is advisable to provide a perforated false bottom in the receptacle to keep the drug intended for extraction and to avoid charring.
  • 13. Procedure • The copular reservoir over the lid is filled with cold water during distillation and it serve as a sort of crude type of condenser. • This crude device could be replaced by a good condenser in the form of a water jacket around the exhaust tube, or even a spiral type of condenser could be provided.
  • 14. Methode of preparation Coarsely powdered drug + prescribed quantity of water soak drug overnight + drug turns soft transfer to arka yantra and boil vapour is condensed distillate is collected in receiver
  • 15. End of the process • The end of the process of Arka preparation is marked by the escape of dark fumes from the exhaust. Further attempts to heat and collect the remnants of condensate should not be made once this phenomenon is noticed. • Usually the volume of the distillate is 3/4th of the total volume of the drug and water mixture taken for distillation.
  • 16. Final product • Thus produced Arka is a suspension of the distillate in water having slight turbidity. • Depending upon the nature of the crude drugs under going for the distillation, the Arka will have characteristic colour and odour.
  • 17. Precautions • While doing Arka preparation, distillation apparatus should be exposed with Mandagni, because boiling of the drugs with excessive heat will lead to water getting vaporized early. There by spoiled kwatha like preparation will be produced. • Because of more heat, very soon the water content will get vaporized and there is a chance of burning and spoilage of arka dravya, then little bit arka is produced which contains improper taste, smell and which will not be up to mark.
  • 18. Precautions • The lid should be tightly placed and sealed around to prevent vapors from escaping. • Heat is applied to the drug mixture and the distillate is collected in large bottles and mixed well to ensure uniform concentration of the medicine because the first distillate is much concentrated compared to that collected at the end of the process when the drugs are depleted of the medicinal principles.
  • 19. Precautions • Continuous water current should be maintained in the condenser. • When a copular type of condenser is used, water is replaced by cool water when it becomes warmed up. • The vessel or bottle in which the distillate is collected is placed in a container containing cold water.
  • 20. Shad Agnis in preparation of Arka kalpana Sl. no. Type of agni Total time taken Quantity of fuel feature 1 dhumagni 2 yama Not mentioned Wihtout any flame if there is huge amount of fume 2 deepagni 1 ½ yama 2 Part of the quarter of mushti If the flame of dhumagni is increasesed to 2 or 4 times 3 mandagni 1 yama Quarter of one mushti If the flame of dipagni is again increased to 4 times 4 madhyamagni Between diptagni and mandagni ½ mushti The agni in which the flame is in between dipagni and mandagni
  • 21. 5 kharagni 1 muhurtha 2 ½ mushti Fifth part more than that of madhayamagni is kharagni, this agni is used for all purposes 6 Bhatagni 1 muhurtha Not mentioned The agni in which the flame spreads all over the bottom
  • 22. Different methods of preparation of arkas Type of drug quantity of water exmples Atyanta khatina 3 parts chandana khatina 2 parts ajamoda Sarasa nala 20 part Nirgundi, eranda patra 100 part vasa nirasa 20 part Vata, ashwatha Mridu dugdhika 4 parts Dugdhika
  • 23. Tikshna dugdhika 10 parts satala phala not added Amra Kashta oushadas 80 parts of water, udumbara Atipakwa phala not added kadali pushpa 16 parts Gulab arka Katu phala 40 parts pippali Drava dravya not added Gomutra
  • 24. Prashasta Arka Lakshana SìurÉÉSÍkÉMüxÉÉæaÉlkrÉÇ rÉÎxqɳÉMåïü mÉëSÛzrÉiÉå | eÉÏhÉÉïÎxjÉmÉɧÉxÉÇͤÉmiÉÉå SìurÉuÉhÉï: mÉëSÛzrÉiÉå || zÉÇZÉMÑülSålSÒkÉuÉsÉÉåÅlrÉjÉÉmÉɧÉÉliÉUÎxjÉiÉ: | ÎeÉÀûÉåmÉËUaÉiÉ: xuÉÉSÇ S±ÉSèSìurÉpÉuÉÇ iÉÑ rÉç: ||(A.mÉë.1/74-75) • Clear and transparent • Must have taste of ingredients • It must comprehend the odour of ingredients • It must have the same colour of drugs if kept in jeernasthimrithika patra • If kept in other vessels it should have the colour of shanka and chandra
  • 25. QUALITIES OF AN ARKA UNFIT FOR THERAPEUTIC USE : aÉÑhÉÉrÉ mɶÉÉixÉåuÉåiÉ iuÉlrÉjÉÉÅmÉaÉÑhÉÉå pÉuÉåiÉ | SÒaÉïlkÉÇ pɤÉrÉåSMïü rÉÌS qÉÉåWûÉiMüjÉgcÉlÉ || iÉSÉÅxrÉ eÉÉrÉiÉå asÉÉÌlÉuÉÉïliÉqÉÉsÉxrÉMÇü iÉjÉÉ | iɬÉåwÉxrÉ ÌuÉlÉÉzÉÉrÉ MÑürÉï²ÉÎliÉqÉiÉÎlSìiÉ: ||(A.mÉë.1/77-78) • Unpleasant odour • If it causes giddiness • If it is turbid • If taste colour etc… have changed.
  • 26. NATURE OF THE VESSEL FOR STORAGE OF ARKA eÉÏhÉÉïÎxjÉmÉɧÉå aÉÚ̺ûrÉÉSMïÇ uÉÉ MüÉcÉxÉqpÉuÉå | mÉÉwÉÉhÉMåüÅjÉuÉÉ mÉɧÉå ApÉÉuÉå qÉÚlqÉrÉå lrÉxÉåiÉç || (Aç.mÉë 1/87) • Jeernasthimrithika patra • Glass • Stone • Clay
  • 27. Mode of administration of arka • Pana-Shopha : punarnava+satala+haridra+kumarika • Swedana - Shopha ‘’ • Nasya - lasuna arka,aromatherapy • Gandusha - Dantaroga : nila +katu+kakajangha • Anjana - sitamanashiladi anjana • External application - Gulab arka
  • 28. What should be done after consumption of arka • ÌmÉoÉåSMïüqÉÌlÉuÉÉïrÉïÇ mÉÏiuÉÉ iÉÉqoÉÑsÉpɤÉhÉqÉç | MÑürÉÉïSpÉÑ£üiÉÉqoÉÑsÉÉå sÉuÉÇaÉÇ pɤÉrÉå¨ÉÑ cÉ ||(A.mÉë.1/88) • In arka prakasha it is mentioned that after taking of arka, Tambula or Lavana sevana should be done.
  • 29. Shelf life / Expiry date: • 1 year from the date of manufacturing (Rule 161-B of D&C Act) Dose: • API: 10 to 20 ml per day in divided doses. • AFI: 12 to 24 ml per day in divided doses. Anupana: • Equal amount of water
  • 30. Arka and Mano Gunas • Avartita arka is tamasika which is taken for doing nishiddha karmas and to induce nidra. It is liked by Pishachas • The arka made from rice water (manda) is rajasika. It is consumed for doing sahasa karmas. • All others will come under satvika. It is good for those who are engaged in geetha hasya karmas.
  • 31. Modern View • In modern pharmaceutics, Arka kalpana can be compared to distillation. • Distillation is the process of separating the constituents of a liquid by vaporizing the liquid and passing the vapors through a cold surface and thereby converting the vapors again into liquid. • There are different types of distillation which include Simple distillation, Fractional distillation, Steam distillation, Vacuum distillation and Destructive distillation etc.
  • 32. Simple Distillation • It is the separation of volatile liquids from non- volatile solids(drugs). • It is the conversion of liquid into vapors and again condensing vapors into liquids • The apparatus used is simple distillation apparatus . It consists of still, condenser and receiver. Fractional distillation • It is the process to separate two volatile liquids with different boiling points Eg: mixture of alcohol and water where alcohol is more volatile and evaporates faster than water.
  • 33. Steam distillation • Steam distillation is a method for distilling compounds which are heat-sensitive. • The temperature of the steam is easier to control than the surface of a heating element, and allows a high rate of heat transfer without heating at a very high temperature. • This process involves bubbling steam through a heated mixture of the raw material. • Some of the target compound will vaporize. Then vapor mixture is cooled and condensed, usually yielding a layer of oil and a layer of water.
  • 34. • Steam distillation of various aromatic herbs and flowers can result in two products; an essential oil as well as a watery herbal distillate. • The essential oils are often used in perfumery and aromatherapy while the watery distillates have many applications in aromatherapy, food processing and skin care.
  • 35. Vacuum distillation • The distillation carried out under reduced pressure. • A liquid boils when its vapor pressure becomes equal to the atmospheric pressure • So liquids can be boiled at a much lower temperature than its boiling point if the pressure on the surface of the liquid is reduced. • Claisen flask- still for vacuum distillation
  • 36. Destructive distillation • Destructive distillation or Dry distillation , despite the name, is not truly distillation, but rather a chemical reaction known as pyrolysis in which solid substances are heated in an inert or reducing atmosphere and any volatile fractions, containing high-boiling liquids and products of pyrolysis, are collected. • The destructive distillation of wood to give methanol is the root of its common name – wood alcohol.
  • 37. Analytical parameters 1. Description Colour Odour 2. pH 3. Volatile matter 4. Specific gravity at 200C (generally 0.991-1.0) 5. Clarity test 6. Identifications, TLC/HPTLC/GLC 7. Assay for essential oil
  • 38. 8. Test for heavy metals- Pb, Cd, Hg, As 9. Microbial contamination- Total bacterial count Total fungal count 10. Test for specific Pathogen- E. coli, Salmonella spp., S. aureus, Pseudomonas aeruginosa. 11. Pesticide residue- Organochlorine pesticides Organophosphorus pesticides Pyrethroids
  • 39. Some examples : Ajmoda Arka: • Agnimandya, Ajeerna, Bastiroga, Vatakapharoga. Brahmi Arka: • Buddhi mandata, Smriti bhrama. Jatamansi Arka: • Agnimandya, Arocaka, Mukha daurgandhya, Unmada, Apasmara.
  • 40. Gulaba Arka: • Daha, Trishna, Hrillasa, Netraroga. Kakmachi Arka: • Hrid roga, Yakridroga, Sotha. Munditika Arka: • Pleeha roga, Meha, Vataroga, Tvakroga, Arunsika. Satahva Arka: • Jvara, Vata Kaphaja roga, Vrana shula, Netraroga, Agnimandya, Atisara. Mishreya Arka: • Mandagni, Adhmana, Shula, Krimi, Yoni shula
  • 41. Parpata Arka: • Jvara (fever), Trishna, Atisara, Daha. Pudina Arka: • Chardi, Ajeerna, Udara shula, Agnimandya. Punarnava Arka: • Jalodara, Sotha, Netraroga. Yavani Arka: • Trika shula, Agnimandya.
  • 42. Different study’s on arka kalpana • A study on Medovriddhi (Obesity) and its management with Medohara Arka • N.C. Das, Nagendra Prasad and B.K. Das,2005, IJRAP • Conclusion : Study reveals maximum improvement, moderate improvement, mild improvement and unsatisfactory being 5%, 75%, 15% and 5% respectively.
  • 43. EVALUATION OF JATAMAMSI ARKA ON ESSENTIAL HYPERTENSION conclusion: Jatamamsi Arka being Deepaka- Pachaka, Tridosha hara, Medhya, Rakta dosha hara , Medohara and Mootrala, acted over all these aspects and thus proved effective in reducing both systolic and diastolic pressure.
  • 44. A COMPARATIVE STUDY OF ERANDAMULADI NIRUHA BASTI WITH & WITHOUT GOMUTRA ARKA IN THE MANAGEMENT OF VATA KAPHAJA GHRIDHRASI CONCLUSION:The Basti with GA group is more potent in mitigating Vata and Kapha and also potentiating Agni.
  • 45. Antimicrobial Activities of Cow Urine Distillate Against Some Clinical Pathogens • Arunkumar Sathasivam, 1 2M. Muthuselvam and 1Rajasekaran Rajendran • Conclusion :Maximum antibacterial activity was observed in Pseudomonas aeruginosa and Salmonella typhi . Antifungal activity of cows urine distillate was analyzed against Aspergillus niger and Aspergillus flavus.
  • 46. Arka as Bio-enhancer • Gurupreet kaur Randhava Department of Pharmacology, Government Medical College, Amritsar • Conclusion: Gomutra arka enhances the transport of antibiotics, rifampicilin, tetracycline & ampicilin across the gut wall as well as across artificial membranes.
  • 47. • The Effect of Rose Water Inhalation on Cardiac Parasympathetic Activity • S. Mehran Hosseini1, Mohsen Jamshir • In effect of 120 seconds rose water odour inhalation parasympathetic tone (HF) increased and heart rate (HR) and sympathetic tone (LF/HF) decreased. Differential and direct parasympathetic modulation may account for part of this effect.
  • 48. Discussion • In the present era, very less people prefer kashaya because of its palatibility. Arka is nothing but the lost partof kashaya. So, it can be used at the place of kashayas with better patient compliance. • Many Arkas are mentioned in various authentic books of Ayurveda. They are not much popular in the market. The reason behind it may be the lack of knowledge about this kalpana. • Though different modes of administration are told,its usage is usually limited as Pana, nasya and Anjana.
  • 49. Conclusion • Arka is the most potent preparation included under the Panchavidha kalpanas of Ravana • It is the most potent due to dosharahithatva and its specific gunas. It is having increased potency, reduced dose, more shelf life and also easy absorption, fast action and better patient compliance. • Arkas can be prepared from Herbs, Minerals & Animal origin drugs • Arka can be used for secondary preparations • Arka can be prepared from modern distillation apparatus also.
  • 50. • Although 505 arka preparations are mentioned in arkaprakasa ,only few of the preparations are used in clinical practice. • So research works has to done on arka preparations to bring those excellent remedies to the main stream.