SG (acinic cell adenocarcinoma)

1. •
• References:
• http://medind.nic.in/iaa/t13/i12/iaat13i12p631.
pdf
• A 25-year-old male presented to the ENT OPD with
history of swelling of the left side of the cheek since
2-3 years, which gradually kept on increasing to attain
the present size. Patient had no evidence of the facial
nerve abnormality.
• On Examination:
• Swelling present on the left side of the cheek. Soft to
firm on palpation, mobile, no rise of local
temperature, facial nerve was normal.
• Histology:
• Multiple sections show parotid tissue with focally
microcystic and papillary cystic glands lined by acinic
cells displaying granular cytoplasm and focally clear,
vacuolated cells, surrounding stroma contains
lymphoid aggregates, hemorrhage and hemosiderin
pigments. Few areas show laminated concretions like
psammoma bodies within the lumina.
• Dx?
•
• CASE

2. • Acinic Cell Adenocarcinoma
• A malignant epithelial neoplasm in which the neoplastic cells
express acinar differentiation.
• - Location: most frequently in the parotid gland.
• - Clinical presentation: slow growing.
• - Histology: Serous acinar cells, which are most
characteristic of Acinic cell adenocarcinoma, are
large, polygonal cells with abundant and lightly
basophilic and granular cytoplasm. Dense, blue-
purple, fine to coarse zymogen granules are seen.
• - DDx: Adenocarcinoma, not otherwise specified
(NOS).
• - Tx: Excision. Most deep parotid tumors require
postoperative radiation therapy because of the
limitations in resection of these tumors, or radiation
therapy is given as additional therapy for tumors that
are intermediate or high grade.
• - Prognosis: They are usually low grade, but how far
they have grown into nearby tissue is probably a
better predictor of a patient’s prognosis.
• References:
• http://www.cancer.org/cancer/salivaryglandcancer/detailedguide/salivary-gland-cancer-what-is-salivary-gland-cancer
• http://lester-thompson.com/articles/ENTJ/ENTJ-2010-10_Salivary%20gland%20acinic%20cell%20carcinoma.pdf
http://medind.nic.in/iaa/t13/i12/iaat13i12p631.pdf