Make DNA data actionable - Festival of Genomics London 2018

Fred Hassan, Chairman Warburg Pincus
suisselifescience.com © 2018 Suisse Life Science Group plc. All Rights Reserved. 2
Source: CNBC, 01/2018
HARNESSING THE POWER OF THE BIOLOGICAL SCIENCES
THE BIG BANG IS COMING IN HEALTH CARE, AND IT WILL SPARK THE NEXT INDUSTRIAL REVOLUTION
The biopharma innovation flow in 2017 was the most exciting the world has seen.
Industrial revolutions occur when there is an unmet need and when different technologies come together to create magic.
The Fifth Industrial Revolution will be powered by the coming acceleration in harnessing the biological sciences.
Biology is difficult to characterize, difficult to chart on a systems basis. It is ever changing, difficult to intervene at specific intervention points and
can take evasive action when human intervention occurs.
Biology is ruled by nature, much more than the laws of physical science or mechanical science.
Some say as much new research is getting added on in the previous two years as the entire period before that. The cost of sequencing a genome
has dropped below $1,000, a stunning drop from $2 billion level less than two decades ago. This cost will keep dropping. It is estimated that more
than a billion people will soon supply the world's databases with their genomic and phenotypic information to carry out correlations that educate us
about gene variants and their linkage to diseases — and even lifestyles.
THIS FIFTH REVOLUTION, WHICH I PREDICT WILL START IN THE NEXT DECADE, WILL MAKE THIS CENTURY THE LIFE SCIENCES CENTURY
FOR MANKIND. We will succeed in taming biology and making it into a more predictable science that can be harnessed, similar to the way the
previous four industrial revolutions harnessed the physical and mechanical sciences. As the Fifth Industrial revolution unfolds, more and more of us
will be living longer and living better.

DIRECT-TO-CONSUMER GENETIC HEALTH TESTING
CONSUMERS ARE LOOKING FOR MORE CONTROL OVER THEIR OWN HEALTH AND HEALTHCARE, AND
WITH THE ADVENT OF AFFORDABLE GENETIC TESTING THERE ARE NEW AVENUES FOR PERSONALISED
TREATMENT AND PRECISION MEDICINE.
STRONG GROWTH (2018-2022) +25.6%
DTC GENETIC TESTING MARKET FROM $99 MILLION TO MORE THAN $310 MILLION IN 2022
EASING OF THE REGULATORY PROCESS FOR DTC GENETIC TESTS
CHANGES IN THE DOCTOR-PATIENT RELATIONSHIP
As consumer tests come to the fore and patients arrive at their doctor appointments brandishing their own genetic data and full of
questions and opinions. Concerns still remain that patients – and not a few physicians – don't always understand what the genetic
results mean and just what to do about them. But as consumers get more comfortable with those companies' offerings, the visits with
their doctors are often getting more complex.
With the increased use of the Internet for medical information, consumers have become medical consumers not just patients This has
created a change in the doctor/patient relationship as individuals become more knowledgeable about their own health and want more
control over their personal information and treatment decisions. Physicians, meanwhile, are concerned about giving patients too much
access to information they may not properly understand. Even many doctors aren't well-trained in the clinical implications of genetics
and genomics.
Source: Kalorama Information report, The Market for Direct-to-Consumer Genetic Health Testing

Professor Patrick Chinnery, a member of the Medical Research Council,
said the pace of technical advance meant swathes of the workforce need
extra training. Health chiefs are embracing the science, with a large scale
pilot currently running that will lead to a full-scale Genomics Medicine
Service within the NHS. But Professor Chinnery, a mitochondrial specialist
at Cambridge University, told The Telegraph that while current medical
students are being adequately trained, doctors above the age of 30 need
to “get up to date”. He said demonstrating a working knowledge of
genomics could soon be a condition of the re-licensing process all
doctors go through every ﬁve years.
“All doctors will need to be able to understand when to use
genomic testing and how to interpret the results they get back
from the lab in practice,” Professor Chinnery said.
GENOMICS FROM THE LAB TO PRACTICE
In the short-term it’s the
specialists who will use it but
we will increasingly see
patients knowledgeable
about genomics going to
their GPs with questions.
GPs will need to understand
what is possible.
THE CMO’S GENERATION GENOME REPORT IS FOCUSED ON THE NEED FOR THE UK TO MAINTAIN ITS
PRESENCE AS A WORLD LEADER IN GENOMIC MEDICINE. It presented a vision of genomics being
integrated into the NHS within the next 5 years.
THE “VAST MAJORITY” OF NHS DOCTORS ARE “NOT UP TO SPEED” WITH MODERN GENETIC
TECHNIQUES THAT CAN TRANSFORM PATIENTS’ CHANCES.

Even though the number of genetic counsellors has grown 88% over
the last decade— there are currently about 4,200 genetic counsellors in
the U.S. —experts say there won't be an appropriate ratio of
counsellor-to-patients until 2023, at the earliest.
China will need at least 100,000 genetic counselors. “You cannot even
ﬁnd the term for genetic counsellors in the Chinese occupational
classiﬁcation system,” said He Ping, a director at the Genetics Society
of China. With the gradual introduction of genetic testing services into
clinical practice, the industry began to show a supply shortage.
WHAT THE PATIENT WANTS
The world of genomic sequencing and genetic testing has undergone
rapid changes over the last two decades, driven in part by the drop in
the cost of the technology. Now, at-home DNA tests are marketed as
holiday gifts during Black Friday and younger patients are more
interested in obtaining information about their own health — and they
are more willing to pay for it out of pocket. In the past, patients often
gave full autonomy of their health choices and care to their doctors.
That's changing, as MORE PATIENTS WANT TO TAKE OWNERSHIP OF
THEIR HEALTH.
suisselifescience.com 5
WE DON’T NEED MORE DATA – OR MORE GENETIC COUNSELLORS
Population Health Management
Specialization
5%
Hospital or
Specialist
25%
Licensed Clinician
70%
Smart Technologies,
Health Coaches and
Allied Providers
© 2018 Suisse Life Science Group plc. All Rights Reserved.

DATA-DRIVEN MEDICINE
GENETIC TESTING IS DEAD.
A new business model must be created to bring genomics into healthcare. Rather than the traditional
diagnostic testing model, Invitae is working to create this new model through partnering with
pharmaceutical companies, healthcare systems and patient advocacy companies.
The next big opportunity that Invitae is exploring is how genomic data could beneﬁt an asymptomatic
person.
Invitae CEO Sean George

SUISSE LIFE SCIENCE SPECIALISES IN MAKING DNA DATA
USEFUL FOR POPULATION HEALTH MANAGEMENT.
Using our ﬂagship Scienceof[DNA]f(x) technology, Suisse Life
Science Group can provide you with an evidence-based lifestyle
behavioural medicine dynamic system based on the associated
genetic variants supported by literature citations for health,
wellness or chronic diseases, and customised around your
needs.
What used to take weeks of painstaking manual curation can
now be completed in days.
PERSONALISED HEALTH TECHNOLOGY FOR GENOMIC
COMPANIES OR CUSTOM APPLICATIONS
The Scienceof[DNA]f(x) technology - after being validated
through the My iDDNA® proof of concept with more than 2,000
customers - is now available for enterprises and global premium
brands that wants to leverage personalisation from genomics
and an enhanced user experience with a ready-to-market
technology.
GENOMIC INTELLIGENCE
FINDING THE
ANSWER
CAATTCCCAGGCTACCGAACTGTCGAGGGGT
CATAAAGCTACGGGTTAACTGAGCTATTCCAT
AACTCGGGCACAGATTAGGTGGTTACTCAAT
AACTCGGGCACAGATTAGGTGGTTACTCAATT
AACTCGGGCACAGATTAGGTGGTTACTCAATT
IS DIFFICULT

If precision medicine is the future and this type of care is all about the
individual, then the healthcare industry needs to become nimble like an
Amazon to compete against other businesses that are frankly better at
zooming in on consumers’ needs.
“If I bought books on Amazon two years ago, they still know what I like and
need,” said Pﬁzer CMO Freda Lewis-Hall, MD. “I think Amazon is around
changing the dynamic. We are still in a system delivering Star Wars
advancement in technology in a Flintstones’ healthcare system.”
The ability to sequence the human genome to predict adverse health events
and the onset of chronic diseases, that’s the Star Wars part. Meet the
Flintstones: Today’s existing technological infrastructure to support
personalised care and all the data it will demand is not nearly robust enough.
PERSONALISED MEDICINE NEEDS SMARTER DATA
Every two years the world’s database doubles, and every three years health
information alone also doubles.
By 2020, global healthcare data will double every three days – with 80%
of the data being UNSTRUCTURED, without a clear relationship.
To truly get the results consumers deserve, health & wellness data need to
translate into accurate, actionable recommendations for both consumers
and professionals.
PERSONALISED MEDICINE

WORKING AT THE CREATIVE EDGE OF BIOLOGY AND INFORMATICS
This vision of personal health monitoring is becoming achievable in part
because of dramatic cost reductions for sequencing DNA and measuring the
many thousands of biological compounds and processes that regulate the
body. What all that means for any one of us, especially when all the readings
are combined, is unclear. But Suisse Life Science is part of a new wave of
companies that figure they can find something meaningful in the data and
enable medicine to stop merely reacting to an illness you have; these
companies want to keep you healthy at a fraction of the cost. Unlocking this
puzzle, with its millions of moving pieces, is where AI and other advanced
computing techniques will have to come in. AI is how we can take all of this
information and tell you things that you don’t know about your health.
Mainstream medical testing tends to be static, with one test taken at a time—
an EKG in a clinical setting every year or two, for example, or when
symptoms seem to warrant it. Now you’ve the possibility to discover the
early stages of when a person shifts from good health to, say, becoming a
diabetic.
LIFESTYLE AND DATA-DRIVEN MEDICINE FROM DEVICES
The Scienceof[DNA]f ( x ) is an Artificial Intelligence (AI) platform
technology that can automatically read and collate unstructured data, then
learn to make personalised recommendations that will dramatically impact
anybody’s personal health & wellness outcomes or enhance a specific
medication (or medical device) user experience.
ENABLING PEOPLE TO LIVE LONGER, HAPPIER AND HEALTHIER LIVES
THROUGH DNA AND DIGITAL TECHNOLOGY.
DATA-DRIVEN MEDICINE

The critical translation between genotype, biochemistry, gene expression,
biomarker tests, phenotype and personalised advice – based on evidence-
based research – makes the difference in empowering consumers and
practitioners in such a rapidly-evolving ﬁeld.
The beginning of the era of Personalised Precision Medicine is here.
Personalised Medicine involves best practice treatment guidelines being
customised for an individual, based on their unique attributes, their
environment and lifestyle choices, as well as their genomic makeup. Today
we strive to treat the individual, and not just ‘a’ general condition. The
effective development of Personalised Medicine requires the collection and
analysis of large volumes of data that can be subjected to deep machine
learning. In today’s connected world, the aggregation of large volumes of
complete longitudinal medical records of an individual, together with their
unique genomic data in an accessible database, requires bulletproof privacy,
security and access controls for the individual clinical records.
PRECISION MEDICINE PROGRAMS TURN DATA INTO ACTIONABLE
INSIGHTS
Suisse Life Science is a technology company that is building the world's
largest library of molecular data and lifestyle behaviour for an ageing
population linked to individual genetic traits and an operating system to
make that data accessible and useful.
FUTURE HAPPENS. BE READY
TRANSFORM UNSTRUCTURED DATA
We aggregate and structure real time scans to uncover phenotypic,
therapeutic and outcomes data for every customer.
PRODUCE MOLECULAR DATA
Our genomic tests analyze DNA data to understand a customer’s
predisposition at a molecular level and uncover more personalised treatment
options.
GENERATE ACTIONABLE INSIGHTS
Our platform analyses thousands of clinical and molecular data points
supporting our partners with actionable insights for more impactful outcomes.

CONNECTING THE DOTS
BETWEEN DNA AND LIFE02

Disease § Age of 1st occurrence
Heart Disease 610.000 65
Lung cancer 158.060 60
Chronic obstructive pulmonary
disease (COPD)
147.101 45
Stroke 140.000 65
Lower respiratory infections 131.800 75
Alzheimer´s disease 93.541 65
Type 2 diabetes 69.071 54
Colorectal cancers 50.260 70
Breast cancer 40.000 62
Prostate cancer 25.000 66
In the United Kingdom, chronic diseases are projected to account for
85% of all deaths. At least 80% of premature heart disease, stroke and
type 2 diabetes, and 40% of cancer, could be prevented through
healthy diet, regular physical activity and avoidance of tobacco
products.
Cost-effective interventions exist: The most successful strategies have
employed a range of population-wide approaches combined with
interventions for individuals. Using these approaches, the United
Kingdom has already made important gains in reducing chronic
disease death rates.
The World Health Organisation estimates that an additional 2% annual
reduction in national-level chronic disease death rates in the United
Kingdom over the next 10 years would result in an economic gain of 2
billion dollars for the country.
Top ten causes of death in the US and their average or median age of ﬁrst occurrence.
Source: Department of Medicine, Washington University in St. Louis
Lifespan
Healthspan
Average healthspan vs. average lifespan in the US (in years)
THE UNSEEN DILEMMA:
7963
Source: World Health Organization
Healthspan is more important than Lifespan,
so why don’t more people know about it?

Given these statistics, it should be clear that
1) chronic disease is the biggest threat to
our health that we face, and 2) changing our
behaviour is the most important step we can
take to prevent and reverse chronic disease.
The lack of tools, specialty segregation,
limited ability of healthcare professionals to
access unstructured data and follow the
consumer out of the ofﬁce lead to average
diagnostic journeys of over 5-7 years, during
which patients see an average of 5 different
specialists.
FINDING THE ANSWER FOR EACH ONE OF
US IS DIFFICULT:
• What should I eat?
• What vitamins should I take?
• What is the best exercise for me if it was
a difﬁcult week? What if I am exercising
only once a week ?
• My body is changing because of
menopause; what should I do?
ON AVERAGE, WE LIVE UP
TO 20% OF OUR LIVES
UNHEALTHY, NEEDLESS TO
SAY, THAT IS A LONG TIME
HELP ME STAY BETTER
10 MODIFIABLE FACTORS
PREVENT 70-80% OF ALL
CHRONIC DISEASES
CDC report in 2001 chronic diseases contributed
approx. 46% of all disease burden. Proportion is
expected to increase to 57% by 2020.
LIFETIME HEALTH CAUSES
60%
Behavior &
Environment
30%
Genetics
10%
Healthcare
THE PROBLEM
THE DIAGNOSTIC ODYSSEY
AN INTERPRETATION
CHALLENGE
HEALTH COACHING =
BEHAVIOURAL CHANGE

YOUR EXPERTISE - ONE GENE

VALUE CREATION FROM YOUR EXPERTISE WITH MULTI -OMICS RELATIONSHIPS

GIVE A SENSE TO YOUR DNA DATA WITH MULTI -OMICS RELATIONSHIPS

Health Kit
LIFESTYLE
User preferences
Exercise
Stress
Sleep
Nutrition
Drink
At home/Out
ENVIRONMENT
Pollution
UVA-B
Sun exposure
Season
Location
Temperature
Humidity
NUTRITION COUNSELLING
Food selection
Free servings choice (real-time
food environment redesign)
Shopping list
AR Restaurant concierge
DRINK COUNSELLING
EXERCISE COACHING
STRESS MANAGEMENT
PHENOTYPIC TRAITS
24/7 Healthkit monitoring
Pollen
Health goal-matching diet
DIETARY SUPPLEMENT
COUNSELLING
BEHAVIOURAL HEALTH
COACHING
SLEEP COUNSELLING
BIOMARKERS
PERSONALISED LIFESTYLE
RECOMMENDATIONS

VALUE CREATION

FROM GENOMICS TO DAILY LIFE
GENETIC PREDISPOSITION
CONSUMER
Implicit query aspect
Explicit query aspect
CONTEXT
LIFESTYLEENVIRONMENT
Search history
Keywords
Location
SYMPTOMS
HEALTH ASSOCIATED
CONDITIONS
RISK FACTORS
CONTEXT
Like/Dislike
Molecular
interventions
RECOMMEND
AVOID
Behavioural
Coaching
Customised
Products
PERSONALISATION
PHENOTYPE

GIVE A SENSE TO YOUR DNA DATA

VALUE CREATION FROM YOUR EXPERTISE
https://invis.io/D4FG385AWUG

BIOLOGY-PERSONALIZED BEHAVIOURAL HYPER-TARGETING

Arginine
LEAD
Citrulline + NO
Peroxynitrite
Super Oxide
GST
SOD
0BH41BH42BH4
ammonia
NOS
T
Purines
5, 10
Tryptophan Tyrosine
BH4
TALUM
BH2
Serotonin
MAO A
HIAA
Dopamine
COMT
HVA
glutamate gaba
GAD
T
T
T
T
NorEp
SAH
SAMe
SAHCOMT
VMA
VDR
5 Methyl
MTHFR
DHPR
dUMP
THF
Thymidine
MTR
LEAD
B12 MTRR BHMT
DMG
Homocysteine
TMG
CBS
cystathionine
AMMONIA
Cysteine + KG
taurine glutathione
G6PDH
sulfite
sulfate
cortisol
Angiotensin I Angiotensin II
adenosine
Creatine Creatinine
SAH
Guanido AC
Methylation
SAH
DNA, RNA
MAT
Methionine
SAMe
SUOX
ACE
MAO B
MAO B

T
T
VDR
5-MTHF
MTHFR
dUMP
THF
Thymidine
synthesis
MTR
LEAD
B12 MTRR BHMT
DMG
Homocysteine
TMG
SAH
Methylation
SAH
DNA, RNA
Protein, lipids
Methionine
SAMe
MTR/FOLATE CYCLE
MTR (METHIONINE SYNTHASE) combines folate,
methyl B12 and homocysteine into methionine.
MTR variants FASTER PROCESS
MTRR attaches a methyl group to B12
MTRR variants SLOWER PROCESS
MTR+MTRR DISFUNCTIONS
FROM GENOMICS TO DAILY LIFE
NO inhibits MTR and B12.
Subjects with
IMMUNE DYSFUNCTION
CHRONIC FATIGUE SYNDROME
CHEMICAL SENSITIVITY
LYME’S DISEASE
FIBROMYALGIA
tend to have higher NO levels.
B12 DEFICIENCY
ZINC DEFICIENCY
FOLATE DEFICIENCY
SELENIUM DEFICIENCY
ALCOHOL
CANDIDA
THE BIRTH CONTROL PIULL
LEAD
MERCURY (FISH)
CADMIUM (NON ORGANIC FOODS)

SNPs
XB%
ew2%
ew2%
ew2%
PERMUTATIONS
Genetable
METABOLIC TRAITS
ASSOCIATED
HEALTH
CONDITIONS
BEHAVIOURAL HEALTH
NUTRITION
MICRONUTRIENTS
EXERCISE
STRESS
SLEEP
LIFESTYLE
ENVIRONMENT
User preferences | Recommended/Avoid
Foods, dietary approach, caloric restrictions
Micronutrients
Exercise technique, frequency, intensity
Foods, micronutrients, exercise, lifestyle recommendations
XB%
ew2%
ew2%
ew2%
AI Avatar Brain
GOAL AND
PREFERENCES

T
T
VDR
5-MTHF
MTHFR
dUMP
THF
Thymidine
synthesis
MTR
LEAD
B12 MTRR BHMT
DMG
Homocysteine
TMG
SAH
Methylation
SAH
DNA, RNA
Protein, lipids
Methionine
SAMe
ACTIONABLE RECOMMENDATIONS FROM DNA
ALCOHOL
CANDIDA
THE BIRTH CONTROL PIULL
LEAD
MERCURY (FISH)
CADMIUM (NON ORGANIC FOODS)
VITAMIN B2
MANGANESE
Beets
Beet greens
Turnips
Turnips greens
Broccoli
Romaine lettuce
Spinach
Carrots
Romaine
Carrots
Turnip greens
VITAMIN B12
ZINC
VITAMIN B2
Prebiotics
Raw dandelion greens
Garlic
Leeks
Onion
Asparagus
Chicory
Oats
PABA
Mushrooms
Spinach
EGCG
GRAPEFRUIT SEED EXTRACT

Source: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2669907?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-
jamainternalmedicine&utm_content=olf&utm_term=012218&redirect=true
ROI FROM YOUR WORK

The ﬁrst studies have been released showing that AI Smart Apps are
delivering health outcomes comparable to in-person lifestyle
interventions for T2D.
This study showed that use of an AI health coach is associated
with weight loss comparable to in-person lifestyle interventions.
Source: https://diabetes.jmir.org/2017/2/e28/?
mkt_tok=eyJpIjoiWkRkbU0yUTVNR1JpTlROaiIsInQiOiIxQldLM2tDOTNrOEh5OWNJODJwTEJGblA3
TlRNK1VGUGdNTzg3Vis3eEdaQ215dmpSNXVPUVBLdkZ1akY4R0tCaXlOQnc3Mk5ndHNVRldsUzMy
Q0Y0N3BwQkhjdURkWldKQWd0UVgweVd0cVkweGhFR2NWWTh6aGRZd3VKblFzTSJ9#Abstract
AI PERSONAL COACHING

DIGITAL BIOLOGICAL INTELLIGENCE

PRECISION CONSUMER HEALTH THROUGH LIVING DATA
PASSIVE
REACTIVE
PROACTIVE
PREDICTIVE
PREVENTIVE
ENABLED BY DATASYMPTOM-DRIVEN

HEALTHCARE EVERYWHERE: Supporting people through their health challenges

Source: PSFK The Future of Health Vol.3

PERSONALIZED HEALTH PLATFORM
FOR CUSTOM APPLICATIONS03

WHAT FUTURE FOR HEALTH & WELLNESS?
PERSONALISED HEALTH MANAGEMENT TECHNOLOGY
Lifestyle + Environment + Biomarkers (molecular personalization)
Two levels of personalisation outcome:
a) Personalised recommendation engine/personalised regimen
b) Custom formula personalisation.
BUSINESS APPLICATIONS:
• AI PERSONAL NUTRITIONIST or RETAIL ASSISTANT (skincare, supplements,
pharmacies…) for personalised health & beauty purchasing recommendations
• D-T-C PERSONALIsED NUTRITION or SKINCARE business models
• “HEALTH” PREMIUM TIER FOR MEAL-KIT COMPANIES to differentiate and upgrade
the customer base
• PHARMA’S NEW STRATEGIC PARTNER: Nutrition moves to population health. As
established health organisations and new entrants focus on nutrition as a way to
prevent costly medical problems and improve the overall health of the populations
they serve, the demand for these services among populations fuels growth and
innovation.

PERSONALISED NUTRITION
HEALTH & WELLNESS03

FOODTECH AND PERSONALIZED NUTRITION
IS IT POSSIBLE TO DESIGN A BETTER, HEALTHIER AND MORE INDIVIDUAL DIET?
UNDERSTANDING THE RELATIONSHIP BETWEEN FOOD AND GENES MAKE THIS A REALITY.
The alarming rise in the prevalence of obesity and associated pathologies (type 2
diabetes, cardiovascular diseases, hypertension, stroke) points an accusing finger at
the inadequacies between modern diets, a sedentary lifestyle and our genetic
inheritance.
Nutrigenomics relies on these new high-performance tools to define and characterize
«diet signatures» reflecting the action of nutrients on the structure and expression of
the human genome.
“NUTRIGENOMICS IS THE STUDY OF MOLECULAR RELATIONSHIPS BETWEEN
NUTRITION AND THE RESPONSE OF GENES, WITH THE AIM OF UNDERSTANDING
HOW SUCH SUBTLE CHANGES CAN AFFECT HUMAN HEALTH.”  
Chavez A, Munoz de Chavez M . Eur J Clin Nut, 57 (Suppl. 1) 97-100, 2003.
The challenges of nutrigenomics are, first, to prevent illness by detecting nutrient
impacts on biological markers identifying the early stages of diseases.
The second challenge is therapeutic, once the disease takes hold. Here, nutrigenomics
allies itself with pharmacogenomics in seeking maximum benefit from treatments.
Tailor-made nutritional recommendations are already possible, taking into account
individuals’ personal nutritional needs on the basis of their genotype, age, sex, physical
activity and profession, the purpose of all this being to improve the population’s
general state of health.

FOODTECH AND PERSONALISED NUTRITION
Suisse Life Science has already developed, applied and validated all the steps that Food4Me - European Union project focused on personalized
nutrition - acknowledged to translate individual health data into dietary recommendations:
• Explore the best methods for phenotype characterisation, which can be used to assess nutritional status and provide targeted meal
strategies. Phenotypic characterisation means assessing an individual by their physical, biochemical, and physiological traits.
• Compile data on food choice, related nutrient intake, phenotypic data, and genotypic data. This will be used to create algorithms for
personalised nutrition.
• Map out guidelines that connect individualised phenotypes to suggested dietary changes.
• Construct new personalised nutrition tools, including a meal nutrient database, meal coding system and a personalised recipe advice system.
• Provide access to web-based information on healthy eating and meal planning.
TRANSLATIONAL PERSONALISED NUTRITION TECHNOLOGY:
• Level 1: Personalised analysis of an individual’s diet and make recommendations for improved food choice.
• Level 2: Embraces all of level 1, and introduce phenotypic data in addition to dietary data.
• Level 3: Embraces all of level 2, and introduces genotypic data in addition to phenotypic data and dietary data.
Scientiﬁc ref: http://www.food4me.org/scientiﬁc-publications
READY TO MARKET
DATA-DRIVEN
CONNECTED
PERSONALIZED
CONTEXTUALIZED
IMMERSIVE

WHAT FUTURE FOR FOOD? NUTRITIONAL SYSTEMS BIOLOGY
• 4,000 foods
• 22 International cuisines
• AR Healthy Menu Creator
• 10 Medically validated dietary approaches (Mediterranean, Nordic, Zone, Okinawan,
Elimination diet, Fasting mimicking, Alternate day fasting) caliberable on macros
ration, Saturated fats control, Fiber, Glycemic index, Insulinemic index, ORAC, PRAL
• BMR, Body frame index variation
• Religion dietary restrictions (Halal, Hindu, Buddhist, Kosher)
• Food intolerances (lactose, gluten, other (sulfites, Eggs, Milk protein, Peanuts, Dried
fruits, Fruits (citrus), Legumes, Soybeans, Shellfish, Fish, Sesame, Sulfites, Meat,
Cereals (wheat and corn), Apples, plums, apricots, peaches, cherries, almonds, pears,
pineapple, Potatoes and solanaceae (tomatoes, peppers, chilies, aubergine, kiwi,
eggplant, goji), Nickel)
• Pseudo-allergic reactions (hystamine-rich foods, tyramine reaction …)
• Metabolic exercise calculation
• Food frequency and chrono-nutrition controls according to the chosen dietary
approach
• Food seasonality auto-setting
• Shopping list.
SPECIFIC PLANS FOR CHILDREN (age 5-6, 7-10), TEENS (age 11-14, 15-17)

NUTRITIONAL SYSTEMS BIOLOGY TECH


NUTRITIONAL SYSTEMS BIOLOGY TECH (See how we train deep learning tech: https://youtu.be/-UHU0lYNwTY)

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suisselifescience.com © 2017 Suisse Life Science Group plc. All Rights Reserved. 25Health Scale - London
FOR FURTHER INFORMATION
PLEASE CONTACT
Omar Fogliadini
omar.fogliadini@suisselifescience.com
omarfogliadini
omarfogliadini
Suisse Life Science Group plc
The DNA-Lifestyle Company
suisselifescience.com
SIGN UP FOR A DEMO OR BUSINESS APPLICATION CASES AT
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WHAT FUTURE FOR FOOD? MOLECULAR PERSONALISATION
R&D/PRODUCT INNOVATION
• New family of active ingredients
Ref. http://www.actigenomics.com/products/
Swiss company Actigenomics offers natural “active nutrigenomic” ingredients, aimed specifically at
avoiding the weakening of the immune system, the imbalance of bone metabolism and sleep
disorders. The US company Metagenics sells dietary supplements based on nutrigenomics.
Their Protectair range is specifically designed to “strengthen” intestinal flora (intestinal microbiota).
Life Extension™ and Insilico Medicine have announced an exclusive collaborative effort to identify
novel biomarkers of human aging through the use of big data analytics and artificial intelligence,
with the ultimate goal of nutrient formulation discovery to support health and longevity.
• Highly personalised ingredients selection to create mass customised products, for
example: Children, Seniors, Ethnicity-based
• Health-scientific ingredients or combinations for example: Diabetics, Alzheimer’s
prevention, Heart health
Nestlé, via its subsidiary Nestlé Health Science, is taking interest in so-called “nutritional therapies”.
Focus on applying advanced signalling pathway activation analysis techniques and deep learning
algorithms to find nutraceuticals that mimic the tissue-specific transcriptional response of many
known interventions and pathways associated with health and longevity. They will also search for
dietary ingredients referred to as "geroprotectors" that mimic the young healthy signaling state in
older human tissues and use this information to develop novel nutraceutical products to support
health and longevity.

WHAT FUTURE FOR FOOD? FOOD AS MEDICINE
FUNCTIONAL MEDICINE is a science-based system of
personalised medicine that focuses on the root causes of
chronic illness and the correction of these underlying
dysfunctions rather than treating symptoms.
 
FOOD IS NOT JUST THE SUM OF ITS NUTRIENTS
The nutritional value of a food should be evaluated on the basis
of the foodstuff as a whole, and not as an effect of the
individual nutrients.
Scientific references: The American Journal of Clinical Nutrition, http://ajcn.nutrition.org/content/105/5/1033
Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps.
Authors: Tanja Kongerslev Thorning, Hanne Christine Bertram, Jean-Philippe Bonjour, Lisette de Groot, Didier Dupont, Emma
Feeney, Richard Ipsen, Jean Michel Lecerf, Alan Mackie, Michelle C McKinley, Marie-Caroline Michalski, Didier Rémond, Ulf
Risérus, Sabita S Soedamah-Muthu, Tine Tholstrup, Connie Weaver, Arne Astrup, Ian Givens
NUTRITIONAL ECOLOGY
Current approaches to analysing human nutrition focusing on
individual nutrients are inadequate and should be replaced by a
more holistic approach, a research paper suggests.
Nutritional ecology, therefore, focuses not specifically on the
organism or its environment, but rather on the dynamic
interface between organism and environment.
Scientific references: Annual Review of Nutrition, Published online ahead of print, doi: 10.1146/annurev-nutr-071715-051118
“Nutritional Ecology And Human Health”
Authors: Raubenheimer, D.; Simpson, S.J.

PERSONALISED
SKINCARE03

BEAUTY TECH AND PERSONALISED SKINCARE
IS IT POSSIBLE TO DESIGN A PERSONALISED SKIN CARE REGIMEN WITH BESPOKE SKINCARE PAIRED WITH BEAUTY FOODS
SUGGESTIONS AND DIETARY SUPPLEMENTS FOR SIMULTANEOUS AND MAXIMUM BENEFITS?
Estimated to reach $675 billion by 2020, the global beauty industry is
undergoing seismic change that will call for vast innovation and adaptation.
According to WGSN-Future of Beauty the four key trends that will steer the
beauty industry as we head into 2020 are:
1. NEXT GENERATION GENETICS
2. THE ALL-CLUSIVE CONSUMER
3. THE ALWAYS-ON ASSISTANT
4. NATURE HACKING.
Suisse Life Science created as my iDDNA® as validation case history to show
how its technology can differentiate:
• Cosmetic manufacturers
• Cosmetic etailers, retailers and pharmacies
With streamlined, efﬁcient, just-in-time process for a high-end, personalised
beauty on-demand offer aimed to create a winning positioning, customer
loyalty and sales.

Make DNA data actionable - Festival of Genomics London 2018

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Make DNA data actionable - Festival of Genomics London 2018