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Introduction to adverse outcome pathways

On Wednesday 15 January 2020 the OECD hosted a second webinar in the series of Adverse Outcome Pathways (AOPs). It focused on the importance of weight of evidence in the process of developing AOPs, the types and lines of evidences assembled, examples demonstrating the lines of evidence and understanding why quantitative AOPs are developed. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment. Magda Sachana from the OECD Environment Directorate introduced the presenters and scope of the webinar.

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Introduction to adverse outcome pathways

  1. 1. Webinar on Adverse Outcome Pathways: assembling and evaluating weight of evidence (WoE) and quantitative understanding Wednesday 15 January 2020 @ 1 pm (CET, Paris time) / 7 am (EST)
  2. 2. • Why WoE is important for AOP development? • What types/lines of evidence are assembled? • Are there examples demonstrating the lines of evidence? • Why quantitative AOPs are developed? Scope of the Webinar
  3. 3. Presenters Enter photo here Enter photo here Enter photo here Bette Meek Kristie Sullivan Dan Villeneuve University of Ottawa Physicians Committee for Responsible Medicine US EPA Introduction to WoE forAOPs Examples of implementing WoE inanAOP Quantitative understanding of relationships and whythat’s important
  4. 4. CONCLUDING REMARKS
  5. 5. • WoE evaluation provides transparency and confidence on assembling scientific knowledge in AOPs. • Quantitative AOPs further enhance the confidence of their use in the regulatory arena. • Data generated in your lab can be an important line of evidence needed to strengthen the development and use of AOPs. Concluding remarks:
  6. 6. Register for our webinar on Adverse Outcome Pathway Knowledge Base (AOP-KB) and AOP developing tips When: Thursday 30 January 2020 @ 1 pm (CET, Paris time) / 7 am (EST) Where: The convenience of your computer When: Thursday 30 January 2020 @ 1 pm (CET, Paris time) / 7 am (EST) Register here
  7. 7. QUESTIONS
  8. 8. • Adverse Outcome Pathways http://www.oecd.org/chemicalsafety/testing/adverse-outcome- pathways-molecular-screening-and-toxicogenomics.htm • Future webinar announcements / Recordings of past webinars: – Webinar Series on Testing and Assessment Methodologies http://www.oecd.org/chemicalsafety/testing/webinars-on-testing-and- assessment-methodologies.htm – Webinar Series on Emerging Science to Improve Chemical Safety http://www.oecd.org/chemicalsafety/testing/webinars-on-emerging- science.htm • Online training material https://learning.aopkb.org/ Useful links - OECD website
  9. 9. Nathalie.Delrue@oecd.org Magdalini.Sachana@oecd.org 2, rue André Pascal - 75775 Paris Cedex 16, France http://www.oecd.org/chemicalsafety/ Thanks For Watching Twitter: https://twitter.com/OECD_ENV YouTube: http://bit.ly/youtube-chemical-safety Subscribe to our newsletter: http://bit.ly/newsletter-chemical- safety

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