N.i.h.e. biotechnology class of 1989

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National Institute for Cellular Biotechnology

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Shannon Nelson is a PhD student at NICB and her project focuses on analysing the genetic basis of Pancreatic Cancer. Shannon recently produced this slidedeck to explain her research for the 2018 DCU "Tell It Straight" competition. "Tell it Straight" is an annual DCU-run science communication competition that challenges post-graduate PhD students to communicate their research to a general audience and panel of judges that have no prior knowledge of their research, using either a presentation or a video. The competition was held on March 7th 2018 in HG22, Nursing Bldg., DCU.

Turning up the volume on a silent killer: Pancreatic Cancer

National Institute for Cellular Biotechnology

On Dec. 20th 2016, the HRB published their "Health Research In Action" booklet that detailed a small selection of recent success stories from their research funding portfolio which "...really show health research in action". The corneal-limbal stem cell research work carried out at NICB (by Finbarr O’Sullivan and Prof. Martin Clynes) and which led to the first corneal-limbal stem cell transplant in Ireland (carried out by Mr. William Power of the RVEEH) on June 7th, 2016 got an honorable mention (Page 17)

HRB-Health Research In Action booklet (feat. NICB)

National Institute for Cellular Biotechnology

First ESACT Frontiers Retreat, 22-26th October, 2016 (Lyon, France) Program & Abstract Book The European Society for Animal Cell Technology (ESACT) brings together scientists, engineers and other specialists working with animal cells in order to promote communication of experiences between European and International investigators and progress the development of cell systems and their derived products. ESACT was founded in 1976 to create a forum for the exchange of ideas on biological and engineering techniques to promote knowledge and the use of human and animal cells e.g. for the manufacturing of products. Members include scientists and engineers in academic, medical and industrial R&D and Production at applied science institutions and universities, in the medical services, in industry, and in the political and regulatory bodies. ESACT actively encourages interactions between academia, governmental and policy making agencies and the manufacturing and service industries.

Program & Abstract Book: First ESACT Frontiers Retreat, 22-26th October, 2016...

National Institute for Cellular Biotechnology

NICB & NCTCC: 20 years of Research_Symposium Booklet 01-02-2008

National Institute for Cellular Biotechnology

Nihe letterhead

National Institute for Cellular Biotechnology

Nat.bioprocessing unit

National Institute for Cellular Biotechnology

Industrial biotech unit promotional flyer

National Institute for Cellular Biotechnology

BRI services to animal cell technology industry flyer

National Institute for Cellular Biotechnology

Bio Research Ireland (BRI) report 1994

National Institute for Cellular Biotechnology

Increase the cell densities of your CHO processes and improve your product yield using our novel DECOY-7 miRNA technology. We used advanced profiling technologies to identify microRNA 7 (miR-7) as a key contributor to improved CHO bioreactor performance following a temperature shift from 37°C to 31°C. Subsequent functional studies using mimics and inhibitors confirmed the potential of miR-7 as a genetic engineering target within CHO cells, whereby depletion has a beneficial effect on some of the traits desirable in production CHO cells, particularly increasing cell density during the early growth phase and viability during later culture and doubling product yield of a model secreted glycoprotein. These features together have the potential to increase per-run profitability, decrease time required to deliver requisite titres and decrease downstream purification time. Cells grow to a higher density and last longer in culture, resulting in increased per-run titres, increased per-run profitability and decreased time required to deliver product titres. Cell viability is improved, resulting in less contaminating protein from dead cells, facilitating downstream purification.

DECOY-7 Slidedeck

National Institute for Cellular Biotechnology

The NICB (National Institute for Cellular Biotechnology) is located on the Dublin City University (DCU) campus in Dublin, Ireland. It is a leading multidisciplinary centre of translational research in fundamental and applied cellular biotechnology, molecular cell Biology, ocular diseases and biological chemistry. It includes a multidisciplinary team of Cell and Molecular Biologists, Biotechnologists, Chemists and Informatics specialists. The NICB prioritises translational research involving collaborations with industry and with clinicians, and is committed to educating people from all backgrounds in the area of Biomedical Science. This slideshare summarises the main research areas of the NICB, including: Molecular basis for biopharmaceutical production by animal cells Cancer – drug resistance, invasion and biomarkers Tissue Engineering/Stem Cell Therapy – ocular diseases, diabetes Using animal cells as research tools and models for disease research

Nicb Research Overview

National Institute for Cellular Biotechnology

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Mustard, as a crop, is susceptible to a variety of pests that can affect its growth and yield. Here’s a rundown of some common pests that target mustard plants: Aphids: These small, sap-sucking insects can cause significant damage by feeding on the leaves and stems. Aphids also excrete a sticky substance known as honeydew, which can lead to the growth of sooty mold on the plants. Flea Beetles: These tiny beetles jump like fleas when disturbed and chew small holes in the leaves. They are particularly damaging in the early growth stages of the plant. Cabbage Loopers: The larvae of a type of moth, these caterpillars are known for their distinctive looping movement. They chew large holes in the leaves and can defoliate plants if present in large numbers. Diamondback Moth Larvae: Another caterpillar pest, these larvae chew small holes in the leaves and can cause extensive damage, especially when infestations are heavy. Whiteflies: These are tiny, winged insects that feed on plant sap and can quickly become a problem in greenhouse or close planting conditions. Like aphids, they also secrete honeydew. Cutworms: These are the larvae of certain types of moths and are known for cutting young plants at the stem base at ground level. They are most destructive during the night. Root Maggots: The larvae of root maggot flies, these pests attack the roots of mustard plants, causing wilting and potentially killing young plants. Harlequin Bugs: These are colorful stink bugs that suck the sap from mustard plant stems and leaves, causing the leaves to become stippled, wilt, and eventually die if the infestation is severe. Mustard Sawfly: The larvae of the mustard sawfly can cause considerable defoliation, as they feed voraciously on the leaves. Clubroot: Caused by a fungus-like organism, clubroot affects the roots, causing them to swell and distort. While technically a disease, it is often associated with pest management because controlling it involves similar preventative strategies. Control Measures: Managing pests in mustard involves a combination of cultural, biological, and chemical methods. Crop rotation, resistant varieties, timely sowing, maintaining plant health, and using natural predators like ladybugs and parasitic wasps can help keep pest populations under control. Chemical pesticides should be used as a last resort due to their potential impact on the environment and non-target species.

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Forensic Biology & Its biological significance.pdf

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Context. WASP-76 b has been a recurrent subject of study since the detection of a signature in high-resolution transit spectroscopy data indicating an asymmetry between the two limbs of the planet. The existence of this asymmetric signature has been confirmed by multiple studies, but its physical origin is still under debate. In addition, it contrasts with the absence of asymmetry reported in the infrared (IR) phase curve. Aims. We provide a more comprehensive dataset of WASP-76 b with the goal of drawing a complete view of the physical processes at work in this atmosphere. In particular, we attempt to reconcile visible high-resolution transit spectroscopy data and IR broadband phase curves. Methods. We gathered 3 phase curves, 20 occultations, and 6 transits for WASP-76 b in the visible with the CHEOPS space telescope. We also report the analysis of three unpublished sectors observed by the TESS space telescope (also in the visible), which represents 34 phase curves. Results. WASP-76 b displays an occultation of 260±11 and 152±10 ppm in TESS and CHEOPS bandpasses respectively. Depending on the composition assumed for the atmosphere and the data reduction used for the IR data, we derived geometric albedo estimates that range from 0.05 ± 0.023 to 0.146 ± 0.013 and from <0.13 to 0.189 ± 0.017 in the CHEOPS and TESS bandpasses, respectively. As expected from the IR phase curves, a low-order model of the phase curves does not yield any detectable asymmetry in the visible either. However, an empirical model allowing for sharper phase curve variations offers a hint of a flux excess before the occultation, with an amplitude of ∼40 ppm, an orbital offset of ∼−30◦ , and a width of ∼20◦ . We also constrained the orbital eccentricity of WASP-76 b to a value lower than 0.0067, with a 99.7% confidence level. This result contradicts earlier proposed scenarios aimed at explaining the asymmetry observed in high-resolution transit spectroscopy. Conclusions. In light of these findings, we hypothesise that WASP-76 b could have night-side clouds that extend predominantly towards its eastern limb. At this limb, the clouds would be associated with spherical droplets or spherically shaped aerosols of an unknown species, which would be responsible for a glory effect in the visible phase curves.

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