Nosocomial infections (NIs), also known as hospital-acquired infections, occur in over 5% of hospital patients. They can increase mortality, length of stay, treatment costs, and antibiotic usage. Common types of NIs include urinary, respiratory, surgical site, and bloodstream infections. Bacteria such as E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa are frequent causes. Prevention strategies focus on excluding infectious sources, breaking transmission chains, boosting patient immunity, and surveillance. Regular monitoring helps identify outbreaks and ensure best practices are followed.