Haemopoiesis

Introduction ,[object Object],[object Object]

Prenatal and neonatal haemopoiesis ,[object Object],[object Object],[object Object]

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Functions of haemopoietic organs and related tissues ,[object Object],[object Object],[object Object],[object Object]

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Postnatal haemopoiesis ,[object Object],[object Object],[object Object],[object Object]

[object Object],Cortical bone Trabecula bone Adventitial process Vascular sinus Haemopoietic space Central vein

Hemopoiesis in avian bone marrow ,[object Object],[object Object],[object Object],[object Object]

Hemopoietic stem cells ,[object Object],[object Object],[object Object],[object Object]

Pluripotential Stem Cell Myeloid stem cell Lymphoid stem cell

Myeloid stem cell CFU-MEG CFU-E CFU-GM CFU-EOS CFU-BAS Megakaryocyte Rubriblast Monoblast Myeloblast Myeloblast Myeloblast Platelets Erythroblasts Monocyte/Macrophage Neutrophils Eosinophils Basophils

Lymphoid stem cell T- Cell precursors B- Cell precursors Lymphoblast Lymphoblast T-lymphocyte B-lymphocyte/plasma cell

Pluripotential stem cell ,[object Object],[object Object],[object Object],[object Object]

Committed Hemopoietic cells ,[object Object]

Factors regulating hemopoiesis ,[object Object],[object Object],[object Object]

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Regulation of Committed Progenitor Cells ,[object Object]

Lymphoid Tissues ,[object Object],[object Object],[object Object],[object Object]

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Erythropoiesis ,[object Object],[object Object],[object Object]

CFU-STEM BFU-E CFU-E Rubriblast series Erythrocyte Erythropoietin low conc. Erythropoietin low conc. Erythropoietin high conc. Macrophage factor Cell-cell interaction, microenvironment, Burst forming activity, macrophage products, lymphocyte interleukin 1,2,3

[object Object],NRC Erythroid cells

Megakaryocytopoiesis and thrombopoiesis ,[object Object],[object Object]

Progenitor cell Megakaryoblasts Promegakaryocyte

Ancestors and progenies of haematopoietic cell series Recognizable cell series 1. Pluripotential Stem Cell 2. Unipotential stem cell 2. Unipotential stem cell 3. Myeloblast 4. Promyelocyte 5. Neutrophil myelocyte 6. Neutrophil metamyelocyte 7. Neutrophil stab cell (band) 8. NEUTROPHIL 3. Myeloblast 5. Eosinophil/Basophil myelocyte 8. EOSINOPHIL/BASOPHIL - 6. Eosinophil/Basophi metamyelocyte 7. Eosinophil/Basophi stab cell/band

[object Object],1 3 4 5 6 7 8 2 Recognizable cell series Pluripotential Stem Cell Unipotential stem cell Unipotential stem cell Proerythroblast Early normoblast Intermediate normoblast Late normoblast Metarubricyte Reticulocyte ERYTHROCYTE Lymphoblast Prolymphocyte LYMPHOCYTE

Recognizable cell series 1. Pluripotential Stem Cell 2. Unipotential stem cell 2. Unipotential stem cell 3. Megakaryoblast 4. Promegakaryocyte 5. Early megakaryocyte 6. Mature megakaryocyte 7. Productive megakaryocyte 8. PLATELET (Thrombocyte) 3. Monoblast 5. - 8. MONOCYTE 4.- 6. - 7. -

Terminology in erythrocytic series ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fig. 11: Human bone marrow: Lymphocyte (a), mature neutrophil (b), normoblast (c), band neutrophil (d), normoblast (e), W-Giemsa x 400

Fig. 11: Human bone marrow: Neutrophilic, metamyelocytes (f, g), mature eosinophil (h), neutrophlic myelocyte (i), eosionophilic myelocyte (j), lymphocyte (k). W-Giemsa x 400

Fig. 11: Human bone marrow: Neutrophilic myelocyte (m, n), lymphocytes (o), late neutrophilic metamyelocyte (p), neutrophilic myelocyte (q), monocyte (r). W-Giemsa x 400

Haemopoiesis

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Haemopoiesis