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STRATEGIES TO
PREVENT & CONTROL
HPV INFECTION
AND CERVICAL CANCER
DR. SHARDA JAIN
Dr. Jyoti Agarwal
Dr. Jyoti Bhaskar
Review this Lecture and others at:
Slideshare.net/lifecarecentre
STRATEGIES TO PREVENT & CONTROL
HPV INFECTION AND CERVICA...
3
Take home messages of 2 symposium on
Burden of HPV infection and Cervical cancer
Delhi 4/7/2015
Presentation Outlines
•Facts on cancer cervix
•Strategy to prevent and control HPV
infection and cervical cancer
•Need of ...
An Airbus-320 full of WOMEN crashing every day in India
Deaths Due to CaCx
JUST THINK!!!
WHO has estimated that
India contributes to
ONE –THIRD
of the Global burden of
Incidence
Deaths
Due to Cervical Cancer
Women with
• multiple sexual partners are at a higher risk of
cervical cancer
• Women who being sexual activity before 16 ...
• STDs such as HIV are associated with an
increased incidence of human papilloma virus
(HPV) infections
• Persistent HPV a...
Women of the lower socioeconomic status
may not be aware of the illness they are
suffering from and also may not be able t...
Some studies have indicated that
smokingcan be considered as a risk
factor owing to the direct or indirect systemic
effect...
Certain other studies have recorded an
increase in the occurrence of cervical
carcinoma in people whose immune system
has ...
While most women tend to remain asymptomatic
for many months to years,
abnormal discharge and postcoital bleeding
may be o...
•Primary: Vaccination against HPV
Cervical Cancer: Prevention
and Control
Need a comprehensive approach
that includes
CATC...
Cervical Cancer: Prevention
and Control
•Secondary: Screening, detection,
and treatment of pre-cancers
2
Cervical Cancer: Prevention
and Control
•Tertiary: Invasive cervical cancer
management and palliative care
3
Impact of Vaccination
& Screening for
Precancerous lesions
In countries without existing
screening programmes
Like India
Modelling studies suggest that vaccination is
likely to be t...
screening programmes for cervical cancer
•Vaccination +screening are more
effective and cost-effective than
screening alon...
•Screening should continue in order to
detect disease related to non-vaccine
HPV types
•Screening intervals are likely to
...
TAKE HOME MESSAGE
Vaccination& Screening
BOTH are Complementary
to each other,
NOT Substitutes !
CONVENTIONAL
CERVICAL CANCER
SCREENNG
KINDLY SEE 2013 GUIDELINES OF SIX
INSTITUTIONS AND FOLLOW STRICTLY
SCR
The decreased incidence of cervical
cancers in developed countries can be
attributed to early and consistent
cancer sc...
CONVENTIONAL CERVICAL
CANCER SCREENNG
In India,
cervical cancer screening coverage
for all women aged 18-69 yrs
screened e...
This finding necessitates the importance
of start of cancer cervix screening in
India to avoid the huge morbidity and
mort...
1.Stanley M. Vaccine 2006; 24: S106-13, 2.Tindle RW. Nat Rev Cancer 2002;2: 59-65, 3.Stanley M. Vaccine
2006; 24: S16-22, ...
Blood Cervical epithelium
1. Parr EL et al. J Virol 1997;71:8109-15, 2. Nardelli HD et al. J Natl Cancer Inst 2003;95:1128...
Take Home Message
HPV VACCINATION
FOR
ADOLESCENT GIRLS
is
PRIORITY
NUMBER ONE
Take Home Message
SCREENING IS A MUST
PAP’S SMEAR
(21-65 YRS)
Or
SEE &TREAT
To Detect Early & Treat
Precancerous Cervical
...
Take Home Message
30
THANK
YOU
SYMPOPSIUM
DELHI
4/7/2015
DR. SHARDA JAIN DR. SHYAM KUKREJA
ADDRESS
11 Gagan Vihar, Near Karkari Morh Flyover,
Delhi - 51
CONTACT US
9650511339, 9811011690
011-22414049,22058865
WEBS...
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STRATEGIES TO PREVENT & CONTROL HPV INFECTION AND CERVICAL CANCER. Dr. Sharda Jain

HPV prevention, HPV disease , Cervical cancer , cervical cancer prevention , cervical cancer and control Impact of Vaccination & Screening for woman

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STRATEGIES TO PREVENT & CONTROL HPV INFECTION AND CERVICAL CANCER. Dr. Sharda Jain

  1. 1. STRATEGIES TO PREVENT & CONTROL HPV INFECTION AND CERVICAL CANCER DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Jyoti Bhaskar
  2. 2. Review this Lecture and others at: Slideshare.net/lifecarecentre STRATEGIES TO PREVENT & CONTROL HPV INFECTION AND CERVICAL CANCER
  3. 3. 3 Take home messages of 2 symposium on Burden of HPV infection and Cervical cancer Delhi 4/7/2015
  4. 4. Presentation Outlines •Facts on cancer cervix •Strategy to prevent and control HPV infection and cervical cancer •Need of HPV vaccination
  5. 5. An Airbus-320 full of WOMEN crashing every day in India Deaths Due to CaCx JUST THINK!!!
  6. 6. WHO has estimated that India contributes to ONE –THIRD of the Global burden of Incidence Deaths Due to Cervical Cancer
  7. 7. Women with • multiple sexual partners are at a higher risk of cervical cancer • Women who being sexual activity before 16 years of age • Who are sexually active within year of the onset of menses. Who are at risk of Cervical Cancer ? SEXUAL ACTIVITY 1
  8. 8. • STDs such as HIV are associated with an increased incidence of human papilloma virus (HPV) infections • Persistent HPV and cervical dysplasia substantiate their role in carcinoma of the cervix. Who are at risk of Cervical Cancer ? STD 2
  9. 9. Women of the lower socioeconomic status may not be aware of the illness they are suffering from and also may not be able to afford healthcare services , thereby facilitating the progression of cervical precursor lesions. Who are at risk of Cervical Cancer ? LOWER SOCIOECONOMIC STATUS 3
  10. 10. Some studies have indicated that smokingcan be considered as a risk factor owing to the direct or indirect systemic effects on the immune system and local effects of the certain carcinogens in tobacco. 4 Who are at risk of Cervical Cancer ? SMOKING 4
  11. 11. Certain other studies have recorded an increase in the occurrence of cervical carcinoma in people whose immune system has been suppressed either due to some disorder or following organ transplants. Who are at risk of Cervical Cancer ? COMPROMISED IMMUNE SYSTEM 5
  12. 12. While most women tend to remain asymptomatic for many months to years, abnormal discharge and postcoital bleeding may be observed in majority of women with precancerous lesions. HPV Infection & Precancerous Lesions
  13. 13. •Primary: Vaccination against HPV Cervical Cancer: Prevention and Control Need a comprehensive approach that includes CATCH UP VACCINATION No Upper Age Limit Preferrably in ADOLESCENT GIRLS 1
  14. 14. Cervical Cancer: Prevention and Control •Secondary: Screening, detection, and treatment of pre-cancers 2
  15. 15. Cervical Cancer: Prevention and Control •Tertiary: Invasive cervical cancer management and palliative care 3
  16. 16. Impact of Vaccination & Screening for Precancerous lesions
  17. 17. In countries without existing screening programmes Like India Modelling studies suggest that vaccination is likely to be the most effective option to reduce the incidence of cervical cancer2,4 2. Goldie SJ, et al. J Natl Cancer Inst 2004; 96:604–615; 4. Goldie SJ, et al. Int J Cancer 2003; 106:896–904;
  18. 18. screening programmes for cervical cancer •Vaccination +screening are more effective and cost-effective than screening alone for the prevention of cervical cancer and cervical pre- cancer1,2, 3 1. Garnett GP et al. Vaccine 2006; 24:S178–S186; 2. Goldie SJ, et al. J Natl Cancer Inst 2004; 96:604– 615; 3. Elbasha EH, et al. Emerg Infect Dis 2007; 13:28–41 In countries with established screening programmes
  19. 19. •Screening should continue in order to detect disease related to non-vaccine HPV types •Screening intervals are likely to increase once widespread vaccination occurs 1. Garnett GP et al. Vaccine 2006; 24:S178–S186; 2. Goldie SJ, et al. J Natl Cancer Inst 2004; 96:604– 615; 3. Elbasha EH, et al. Emerg Infect Dis 2007; 13:28–41 Screening programmes for cervical Cancer
  20. 20. TAKE HOME MESSAGE Vaccination& Screening BOTH are Complementary to each other, NOT Substitutes !
  21. 21. CONVENTIONAL CERVICAL CANCER SCREENNG KINDLY SEE 2013 GUIDELINES OF SIX INSTITUTIONS AND FOLLOW STRICTLY
  22. 22. SCR The decreased incidence of cervical cancers in developed countries can be attributed to early and consistent cancer screening programme In these counties. WHO Screening programmes for cervical Cancer
  23. 23. CONVENTIONAL CERVICAL CANCER SCREENNG In India, cervical cancer screening coverage for all women aged 18-69 yrs screened every 3 years is only 2.6%
  24. 24. This finding necessitates the importance of start of cancer cervix screening in India to avoid the huge morbidity and mortality associated with cervical cancer. CONVENTIONAL CERVICAL CANCER SCREENNG
  25. 25. 1.Stanley M. Vaccine 2006; 24: S106-13, 2.Tindle RW. Nat Rev Cancer 2002;2: 59-65, 3.Stanley M. Vaccine 2006; 24: S16-22, 4. Stanley M. HPV Today 2007; 11: 1-16 No viremia Local infection, local immunosuppression No cell death, no inflammation, no danger signals Natural HPV infection induces a weak immune response and does not offer full protection against new HPV infection.1-4 Need of HPV Vaccination We need vaccines that induce high immune response than natural infection
  26. 26. Blood Cervical epithelium 1. Parr EL et al. J Virol 1997;71:8109-15, 2. Nardelli HD et al. J Natl Cancer Inst 2003;95:1128-37, 3. Schiller JT et al. Nat Rev Microbiol 2004;2:343-7, 4. Poncelet et al. ESPID, Porto, Portugal 2007; Abstract 37, session ES2, 5. Stanley M. HPV Today 2007; 11: 1-16, 6. Einstein M, Cancer Immunol Immunother 2007; 57:443-51. • Vaccination induces antibodies in the blood and vaccine-induced antibodies can reach to the site of infection1-3 • Higher antibody levels in the blood mean higher antibody levels at the site of infection4 • These antibodies neutralize the virus and prevent entry into cells5,6 Need of Vaccination
  27. 27. Take Home Message HPV VACCINATION FOR ADOLESCENT GIRLS is PRIORITY NUMBER ONE
  28. 28. Take Home Message SCREENING IS A MUST PAP’S SMEAR (21-65 YRS) Or SEE &TREAT To Detect Early & Treat Precancerous Cervical Lesions is Priority Number 2
  29. 29. Take Home Message
  30. 30. 30 THANK YOU SYMPOPSIUM DELHI 4/7/2015 DR. SHARDA JAIN DR. SHYAM KUKREJA
  31. 31. ADDRESS 11 Gagan Vihar, Near Karkari Morh Flyover, Delhi - 51 CONTACT US 9650511339, 9811011690 011-22414049,22058865 WEBSITE : www.globalstemgenn.com www. Stemgenn.com www.lifecarecentre.in E-MAIL ID Contact@globalstemgenn.com Contact @stemgenn.com A UNIT OF ISO 14001:2004 (EMS) …..Caring hearts, healing hands ISO 9001:2008 ISO 9001:2008

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