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Ammg las vegas 2012 110312 final dr bill andrews
- 1. Bill Andrews, Ph.D. Discovered Human Telomerase 2nd Place United States Inventor of the Year Telomere Biologist for 19 Years 31 Years in Biotech Research 43 U.S. Issued Patents on Telomerase Founder, President & CEO Sierra Sciences Popular Science, The Today Show, etc.
- 3. Bad Things Happen When Telomeres Get Short! Telomere
- 4. Telomere
- 11. Congratulations Elizabeth Blackburn, Carol Greider, and Jack Szostak 2009 Nobel Prize in Medicine!
- 14. Some People are Born with Short Telomeres
- 15. Progeria Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20. Short Telomere Disease
- 16. Progeria Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20. Short Telomere Disease Life Expectancy - 20 Years
- 17. Progeria Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20. Short Telomere Disease Life Expectancy - 20 Years Preventing Telomere Shortening Could Cure These Kids!
- 18. Bad Things Happen When Telomeres Get Short!
- 19. Normal Health & Aging
- 20. Short Telomere Diseases • Cardiovascular • Cancer • COPD • Degenerative Disc Disease • Alzheimer’s • Osteoarthritis • Rheumatoid Arthritis • Osteoporosis • General Immunity • Skin Aging • Macular Degeneration • Liver Cirrhosis • Muscular Dystrophy • Cell & Tissue Transplants • AIDS • Progeria • Dyskeratosis Congenita • Idiopathic Pulmonary Fibrosis • Cri du Chat syndrome • Down’s Syndrome • Fanconi’s Anemia • Tuberous Sclerosis • Werner’s Syndrome • And, Aging Itself???????
- 21. Bad Things Happen When Telomeres Get Short!
- 23. 1971: Nixon declares War on Cancer
- 26. What Can Be Done About Telomere Shortening?
- 27. Managing Telomere Length 1. Know the length of your telomeres
- 28. Telomere Testing 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 29. Telomere Testing 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength Normal Line
- 30. A Normal 50 Year Old 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 31. Telomeric < Chronological 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 32. Telomeric > Chronological 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 33. Accelerated Aging 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 34. Progeria 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 35. Always Hope to Be 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 36. Never Want to Be 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
- 37. Telomere Length Measurement 1. Terminal Restriction Fragment (TRF) 2. Q-PCR 3. Fluorescence In Situ Hybridization (FISH) 4. Flow FISH 5. HT Q-FISH 6. Universal STELA
- 38. Telomere Length Measurement 1. Terminal Restriction Fragment (TRF) 2. Q-PCR 3. Fluorescence In Situ Hybridization (FISH) 4. Flow FISH 5. HT Q-FISH 6. Universal STELA Short Telomeres
- 39. Telomere Length Measurement 1. Terminal Restriction Fragment (TRF) 2. Q-PCR – Commercially available 3. Fluorescence In Situ Hybridization (FISH) 4. Flow FISH – Commercially available 5. HT Q-FISH – Commercially available 6. Universal STELA
- 40. Telomeres Shorten as Cells Divide Hastings, et al. Cell Prolif. 37, 317-324 (2004)
- 41. Telomeres Shorten with Age Tsuji, et al., Forensic Sci Int 2002
- 42. Okuda, K., et al., Atherosclerosis, 2000 Telomeres Shorten with Age
- 43. Weak Correlation? People born with different telomere lengths Rates of cell division differ between people Different environmental factors accelerate telomere shortening Poor Signal Detectability
- 44. Weak Correlation? Good for Population Studies or Looking at Major Differences in Individuals
- 45. Abundance of Short Telomeres?
- 47. Managing Telomere Length 1. Know the length of your telomeres 2. Decrease the rate of telomere shortening
- 48. Exercise
- 49. German National Track and Field Team Werner, et al., Circulation. 2009 Dec 15;120(24):2438-47 p < 0.001
- 50. German National Track and Field Team p < 0.001 Werner, et al., Circulation. 2009 Dec 15;120(24):2438-47
- 51. Vigorous Aerobic Exercise LaRocca, et al., Mech Ageing Dev. 2010 Feb;131(2):165-7.
- 52. Physical Activity in Leisure Time Cherkas, et al., Arch Intern Med. 2008 Jan 28;168(2):154-8.
- 53. Stress
- 54. Stress p = 0.05 Damjanovic, et al., J Immunol. 2007 Sep 15;179(6):4249-54
- 55. Stress Epel, et al., Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5.
- 56. Stress Tyrka, et al., Biol Psychiatry. 2010 Mar 5. [Epub ahead of print]
- 57. Depression
- 58. Mood Disorders Simon, et al., Biol Psychiatry. 2006 Sep 1;60(5):432-5.
- 60. 2284 women from the Nurses’ Health Study Cassidy, et al., Am J Clin Nutr. 2010 Mar 10. [Epub ahead of print]
- 61. Valdes, et al., Lancet. 2005 Aug 20-26;366(9486):662-4. p = 0.031 p = 0.019 p = 0.017 p = 0.045 Obesity Smoking
- 62. Smoking p = .001 Morlá, et al., Eur Respir J. 2006 Mar;27(3):525-8.
- 63. Omega 3 Fatty Acids
- 64. Omega 3 Fatty Acids Farzaneh-Far, et al., JAMA. 2010 Jan 20;303(3):250-7.
- 65. Vitamin D
- 66. Vitamin D Richards, et al., Am J Clin Nutr. 2007 Nov;86(5):1420-5.
- 67. Attitude
- 68. The MONICA Northern Sweden Study Self Perceived Aging Nordfjäll et al., Scand J Public Health. 2008 Sep;36(7):744-52
- 69. The MONICA Northern Sweden Study Self Perceived Aging Nordfjäll et al., Scand J Public Health. 2008 Sep;36(7):744-52
- 70. The MONICA Northern Sweden Study Self Perceived Aging Nordfjäll et al., Scand J Public Health. 2008 Sep;36(7):744-52
- 71. Pessimism O’Donovan, et al., Brain Behav Immun. 2009 May;23(4):446-9.
- 72. Keeping Telomeres Long Exercise Anti-Oxidants Omega 3’s Vitamin D3 Don’t Smoke Don’t be Obese Reduce Stress Reduce Depression Reduce Pessimism Be Happy!
- 73. Managing Telomere Length 1. Know the length of your telomeres 2. Decrease the rate of telomere shortening 3. Increase the length of the telomeres
- 80. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. EMBO Mol Med. 2012 Aug;4(8):691-704. Epub 2012 May 15. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
- 81. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. EMBO Mol Med. 2012 Aug;4(8):691-704. Epub 2012 May 15. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
- 85. Reproductive Cells Produce Telomerase Telomerase GeneRegulatory Element
- 86. Telomerase GeneRegulatory Element The Gene is Repressed in All Other Cells
- 89. 39 Families of Chemicals Identified Human Testing within 3 Years
- 90. Natural Products Already on the Market!
- 91. Clinical Studies
- 95. Study #2
- 97. Telomerase Induction In Vitro Chaps 100%Hela 5%Hela MRC5DMSO MRC5Media 0.01uM 0.1uM 1uM 10uM 100uM
- 98. Abundance of Short Telomeres Reduced (Harley, Liu, Blasco, Andrews, Briggs and Raffaele, Rejuvenation Research, 2010)
- 100. Clinical Study Telomerase Induction Short Telomeres Lengthened CD28- T Cells Neutrophils Natural Killer Cells
- 101. Study #3 Completed, but Not Published Yet
- 102. Clinical Study Naive T Cells Blood Pressure Skin Elasticity Bone Density Cholesterol Homocysteine Cognitive Function Glucose Levels
- 104. Study #4
- 105. Clinical Study Faces, Hands, etc., Photographed Short telomeres measured Waist circumference Body Mass Index (BMI) Total Body Water (TBW) Total Body Fat (TBF) Oxidative Stress Panel Routine Urinalysis
- 106. Clinical Study CBC w/Diff Thyroid panel including a Free T3 HSCRP (Highly sensitive C Reactive Protein) Total and free Testosterone Total Estrogen Chem 20 including a lipid profile IGF-1
- 107. Study #5
- 108. Clinical Study Double Blind Placebo Controlled Short Telomeres Measured
- 109. The War has Just Begun!