Gilead Sciences is a biopharmaceutical company headquartered in California that discovers, develops, and commercializes medications for life-threatening diseases. The company has over 3,000 employees across multiple sites globally. While Gilead has had success with environmental programs like an ISO 14001 environmental management system, it recognizes the need to further sustainability efforts. The presentation outlines Gilead's plans to reduce impacts like transportation emissions, water use, and waste through initiatives over the next 5-25 years, leveraging tools like a greenhouse gas inventory and backcasting approach. Green chemistry principles will also help guide process improvements and safer product design.

1. Gilead’s Sustainability and Green Chemistry Efforts Phylmar Regulatory Roundtable Lockheed Martin Missles & Space Sunnyvale CA October 22 2008 Laura D. McHugh, PE, MBA Director, Environmental Health & Safety Gilead Sciences, Inc. – Foster City CA

12. Aspects/Impacts - Examples Air emissions (exhaust) Water consumption Fuel release (accidental spills) Fuel release (accidental spills) Noise generation Energy consumption (hoods/lights) Paper use Air quality degraded Water resource depleted Storm water contaminated Soil contaminated Area nuisance Increased CO 2 Landfill space conserved, raw materials conserved Aspect Impact

18. The Drug Discovery and Development Process Family/Class of Compounds 1-2 Lead Compounds Small Scale Synthesis Scale Up/Pre- Manufacturing Fill/Finish Manufacturing Distribution/Sales