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A Pathogen Purification System for Molecular Diagnosis
Kills more than other several diseases*
1 in 5 deaths associated with sepsis Most causes from bacteria and fungi
1 death e...
Early Sepsis Diagnosis is Essential
0 4 12 36 hrs
Mortality increases 4% -10% per hour
caused by delayed diagnosis*
*https...
Shorter Sample to ResultTime
Below 10 hours of sample to result time
90% accuracy
* quantitative polymerase chain reaction...
Pathogen Purity is Essential
Less than 1000 pathogens in 5 billion cells (0.0001%)
Non-pathogen DNA will interfere qPCR
Bl...
video
Technology to Market
What are the values that our product can bring to customers?
Who are our customers?
Where is our beac...
video
OurVPC for Diagnostic Lab
Gains
PainsPain relievers
Gain creators
Jobs-to-be-done
Shorter processing time Time-saving
Arra...
Market Size of Sepsis Diagnosis for Sepsis
US$ 900 million by 2025 globally and growing at a CAGR of 8.5%
Blood culture
55...
Potential Customers
Hospital
diagnostic
laboratory
Research
laboratory
Commercial
diagnostic
labs
Diagnostic labs which co...
Market Entry Channels
Direct sales in
Singapore
Distributor engagement
overseas
• 9 public hospitals
• 8 private hospitals...
Revenue Streams
Equipment sales
S$25,000 per machine
Recurring chip sales
S$25 per chip estimated
Equipment rental fee
S$1...
• Hospitals
• Product design
company
• Manufacturer
• Alpha prototype
development
• Clinical validation
• Patients: early ...
• Hospitals
• Product design
company
• Manufacturer
• Distributor
• qPCR equipment
vendors
• Alpha prototype
development
•...
Clinical validation
Alpha prototype manufacturing
Alpha prototype development
July 2020
September 2020
January 2021
June 2...
OurTeam
Mentor:Alvin Chung PI:Ye Ai Leader: Lu Xiaoguang
• Executive Director (QuantumDX
Asia)
• 11 years experience in
he...
Our Contact:
• Associate ProfessorYe Ai
• Email: aiye@sutd.edu.sg
• Office: +65 6499 4553
• Lu Xiaoguang
• Email: xiaoguan...
Thank you!
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Puriogen

An automated pathogen purification system for molecular diagnosis

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Puriogen

  1. 1. A Pathogen Purification System for Molecular Diagnosis
  2. 2. Kills more than other several diseases* 1 in 5 deaths associated with sepsis Most causes from bacteria and fungi 1 death every 2.8 seconds Sepsis is a blood-stream infection Sepsis is a Medical Emergency 50 M 1/5 2.8 S 50 million cases per year 50 M 1 / 5 2.8 S * Including breast cancer, prostate cancer, and HIV/AIDS
  3. 3. Early Sepsis Diagnosis is Essential 0 4 12 36 hrs Mortality increases 4% -10% per hour caused by delayed diagnosis* *https://medicalxpress.com/news/2017-05-hour-sepsis-treatment-death.html Mortality 100% 80% 60% 40% 20% 0% Above 36 hours of sample to result time 30% accuracy Blood culture
  4. 4. Shorter Sample to ResultTime Below 10 hours of sample to result time 90% accuracy * quantitative polymerase chain reaction (qPCR) monitors the amplification of a targeted DNA molecule in real time Molecular analysis (qPCR*) 42.5% 10 hours to 1 day More than 90% of clinicians demand diagnosis within 24 hours, especially for ICU patients 50.0% Below 10 hours 7.5% 1-3 days
  5. 5. Pathogen Purity is Essential Less than 1000 pathogens in 5 billion cells (0.0001%) Non-pathogen DNA will interfere qPCR Blood taking qPCR running Result analysisPathogen purification Blood cell Pathogen
  6. 6. video
  7. 7. Technology to Market What are the values that our product can bring to customers? Who are our customers? Where is our beach head market? How high is the entry barrier?
  8. 8. video
  9. 9. OurVPC for Diagnostic Lab Gains PainsPain relievers Gain creators Jobs-to-be-done Shorter processing time Time-saving Arrange resources for testing Provide accurate diagnostic reports Complex handling Pathogen purity too low Automation Capturing pathogen • Faster • Simpler • Efficient
  10. 10. Market Size of Sepsis Diagnosis for Sepsis US$ 900 million by 2025 globally and growing at a CAGR of 8.5% Blood culture 55% Immunoassay 17% Molecular 24% others 4% https://www.grandviewresearch.com/industry-analysis/sepsis-diagnostics-market Blood culture 59% Immunoassay 24% Molecular 13% others 4% 2019 2025
  11. 11. Potential Customers Hospital diagnostic laboratory Research laboratory Commercial diagnostic labs Diagnostic labs which conduct sepsis diagnosis in public and private hospitals Research labs which conduct research on molecular diagnosis in healthcare institutions and universities Commercial diagnostic labs which can conduct molecular diagnosis
  12. 12. Market Entry Channels Direct sales in Singapore Distributor engagement overseas • 9 public hospitals • 8 private hospitals • 75 medical labs in Singapore *https://www.singhealth.com.sg/about-singhealth ASEAN China US Collaboration with qPCR vendors
  13. 13. Revenue Streams Equipment sales S$25,000 per machine Recurring chip sales S$25 per chip estimated Equipment rental fee S$100 per day
  14. 14. • Hospitals • Product design company • Manufacturer • Alpha prototype development • Clinical validation • Patients: early and accurate diagnosis increases the chance of survival • Doctors: early and accurate diagnosis can provide the correct treatment • Hospitals: Healthcare resources will not be overwhelmed • Clinical validation (product specialist) • Partners engagement • Public hospitals (diagnostic labs) • Private diagnostic labs • Clinical and academic research • Direct sales • Regional/overseas distributors • Plastics supply • Key components supply • Clinical samples • Machine design and manufacturing • Chip manufacturing • Clinical validation • IP licensing and maintenance fee • Machine sales (USD 15-20K) • Recurring sales of disposable chips (USD 25 per chip) MOQ: 1, 000 chips • Sub-licensing royalty Our Initial BMC
  15. 15. • Hospitals • Product design company • Manufacturer • Distributor • qPCR equipment vendors • Alpha prototype development • New potential applications finding • Clinical validation • Simplification: one automated step • Higher capturing of pathogen: higher confident level of qPCR testing results • Clinical validation (product specialist) • Partners engagement • Clinicians (recommenders) • Diagnostic lab (users) • Research lab (users) • qPCR equipment vendors (recommender)? • Direct sales • Collaboration • Regional/overseas distributors • Plastics supply • Experimental lab • Key components supply • Clinical samples • Machine design and manufacturing • Chip manufacturing • Clinical validation • IP licensing and maintenance fee • Machine sales (S$ 15-20K) • Recurring sales of disposable chips (S$ 25 per chip) MOQ: 1, 000 chips • Rental fee Our Final BMC
  16. 16. Clinical validation Alpha prototype manufacturing Alpha prototype development July 2020 September 2020 January 2021 June 2021 01 03 02 NextActions Manufacturer Funding Research and clinical lab Key resources
  17. 17. OurTeam Mentor:Alvin Chung PI:Ye Ai Leader: Lu Xiaoguang • Executive Director (QuantumDX Asia) • 11 years experience in healthcare and biotech area • Focus on innovation, IP management and new product development • Associate Professor (SUTD) • Professional expertise lies in micro/nanofluidics, lab-on-a-chip and medical devices • Aims to develop novel microfluidic devices and systems for various biomedical applications • PhD student (SUTD) • Biomedical engineering background and research focus on inertial microfluidics • Aims to develop and apply a benchtop label-free cell sorting system for biomedical applications
  18. 18. Our Contact: • Associate ProfessorYe Ai • Email: aiye@sutd.edu.sg • Office: +65 6499 4553 • Lu Xiaoguang • Email: xiaoguang_lu@mymail.sutd.edu.sg A simpler, faster and more efficient pathogen purification system
  19. 19. Thank you!

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