Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
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Horst's Keynote Stem Cell Science
1.
2. P L A N T S T E M C E L L S C I E N C E
R E V I T A L I Z E R E J U V E N A T E R E S T O R E
EDELWEISS CONEFLOWER PENNYWORT
(Leontopodium Alpinum) (Echinacea Angustifolia) (Centella Asiatica)
A n Eco-brea kt h rou gh in A nt i-A ging Skin Scie nc e:
Ble n d i n g Pla nt St e m C e lls for M a x i m u m Effic a c y
S E P T E M B E R 2 011
3. P L A N T S T E M C E L L S C I E N C E
WHAT IS PLANT
STEM CELL SCIENCE?
An Eco-breakthrough in Anti-Aging Skin Science featuring:
โข A bioadvanced technology in reproducing the highest, most concentrated
and pure plant ingredients.
โข Obtained with a truly eco-sustainable approach.
โข Delivered to the consumer, products that reduce
fine lines and wrinkles, balance skin tone, and
smooth, firm and softens skin.
4. P L A N T S T E M C E L L S C I E N C E
HOW IT WORKS:
PROTECT AND REPAIR
In nature plants are attacked by
environmental stress such as UVA/UVB
radiation, heavy metals, insects, viruses,
micro-organisms and others.
To protect themselves plants use
phenylpropanoids (protecting agents/
antioxidants) which are mainly concentrated
in stem cells.
5. P L A N T S T E M C E L L S C I E N C E
RARE AND PRECIOUS
Super powered and relatively few in number these stem cells are concentrated in the most
vulnerable part of the plant helping to fight against free radical damage while also providing
UV protection and anti-bacterial properties.
Luminescent dots
represent these
highly active cells.
6. P L A N T S T E M C E L L S C I E N C E
REVOLUTIONARY CULTIVATION PROCESS:
HIGHEST POTENCY WITH LESS RESOURCES
It may be a leaf, a flower or a seedโonly a small amount of plant tissue is required to find
specific active substances.
Plant tissue Sampling of sterilized Callus induction in solid
tissues Callogenesis
culture
Callogenesis increases New cell line Selection Scaling Up
7. P L A N T S T E M C E L L S C I E N C E
QUALITY AND SAFETY
The quality and safety of plant active substances have always been a problem
SAFETY
The presence of pollutants and pesticides, heavy metals and aflatoxins is detected in many
plant actives and extracts
AVAILABILITY
Many problems due to difficult accessibility of plants, compromise the availability of
Natural Active Substances
PURITY & STANDARDIZATION
The variability in the concentration of active substances is a limit to the reproducibility of
the biological effect
90% of users of herbal/natural health products declare that safety and efficacy
influence the choice of the product*
*Blumenthal M: Natural Marketing Institute measures consumer use of herbal products. HerbalGram 2000;50:70.
8. P L A N T S T E M C E L L S C I E N C E
BENEFITS
โข The highest, most active molecules can be isolated in a larger quantity with fewer plants
to deliver more efficacious highly potent ingredientsโup to 1,000 times higher in potency.
โข Now through cutting edge technology we can obtain cells from even the most rare plant
species without harm and ensure availability for generations to come as no plant is
destroyed with this method.
โข 100% free from herbicides, pesticides and supports sustainability as soil can be used to
cultivate food.
โข Farming is not required, so no significant contribution to green house gases is produced
from this process.
โข Drastic reduction of water and solvent useโalcohol, glycol and preservatives are not
used in the extraction process.
โข No genetic modification.
9. P L A N T S T E M C E L L S C I E N C E
THE LINK BETWEEN
PLANT & SKIN:
HOW IT HELPS PREVENT THE SIGNS OF AGING
The meristematic cells are concentrated and rich in phenylpropanoids.
Phenylpropanoids are active substances that possess significant antioxidant, free radical
scavenging, and UV protecting and anti-bacterial properties.
As we know skin inflammation and oxidative stress induced by environmental factors
or chemical irritants is a major cause of collagen damage resulting in loss of skin tone,
elasticity and the appearance of wrinkles (the signs of aging).
While intrinsic aging cannot be halted environmental factors can be controlled and
phenylpropanoids are ideal protecting agents since the external damaging factors are
the same for both plants and skin.
10. P L A N T S T E M C E L L S C I E N C E
SUSTAINABILITY:
AN UNAVOIDABLE CHOICE
The extraction of echinacoside requires a 3-year soil cultivation of Echincacea before
collecting roots.
Average inputs for the production of 1kg Echinacea plant stem cells
SOLVENTS (Kg)
BIOTECH
Method
TRADITIONAL
500 Method
WATER (t)
1379
AREA (m2)
1149
0 200 400 600 800 1000 1200 1400
11. P L A N T S T E M C E L L S C I E N C E
SUSTAINABILITY:
AN UNAVOIDABLE CHOICE
The extraction of echinacoside requires a 3-year soil cultivation of Echincacea before
collecting roots.
Average inputs for the production of 1kg Echinacea plant stem cells
SOLVENTS (Kg) HTN IS AN ECO-SUSTAINABLE, GREEN
100 BIOTECH
Method BIOTECH PROCESS:
500 TRADITIONAL
Method โข Preserving biodiversity
WATER (t)
โข Negligible soil occupancy (soil can be
1
cultivated for food)
1379
โข Drastic reduction in water and solvent use
AREA (m2)
3* โข No use of pesticides
1149
High Tech Nature Source: VV.AA., Agronomical trials on Echinacea angustifolia, E.
pallida, E. purpurea, ISAFA 2002/1; G. Nebbia, The cost in water of goods and services,
0 200 400 600 800 1000 1200 1400 University of Rome, 18-19th January 2001, International Water Culture Center.
*323 sq. ft. vs. 1/4 acre of land (10,890 sq. ft.)
12. P L A N T S T E M C E L L S C I E N C E
WE CAN SAVE WATER
One customer using 6 units of 50ml cream can save 1 ton of water per year
= 170 LITERS OF WATER
13. P L A N T S T E M C E L L S C I E N C E
PROPRIETARY BLEND
We have formulated our signature proprietary stem cell blend at the highest potency,
delivering maximum efficacy to revitalize skin cells, rejuvenate aging skin, restore
elasticity and brighten skin. Our blend consists of:
ACTIVE PLANT STEM CELLS ACTIVITY*
โข Reduces wrinkles and helps maintain skin firmness
EDELWEISS โข Rejuvenates damaged cells
{Leontopodium Alpinum} โข Reduces the signs of photoaging
โข Stimulates collagen synthesis (cell renewal)
CONEFLOWER โข Increases hydration and elasticity
{Echinacea Angustifolia} โข Revitalizes dull and tired skin
โข Evens skin tone
PENNY WORT โข Improves elasticity
{Centella Asiatica}
โข Provides firming benefits
*BASED ON LAB AND CLINCAL STUDIES. Results improve with continued use.
14. P L A N T S T E M C E L L S C I E N C E
R E V I T A L I Z E R E J U V E N A T E R E S T O R E
INTERNAL EXTERNAL
(PHASE 2โ2011) (PHASE 1โ On counter September 2011)
15. PHASE 1
P L A N T S T E M C E L L S C I E N C E
RENEWAL COMPLEX
EXTERNAL
Provides intensive treatment benefits to reduce fine lines and wrinkles
diffuse age spots and soften stretch marks and scars, reduce redness
and other skin discolorations. Firms, lifts, smooths and softens while
increasing collagen synthesis.
ALL OVER TREATMENT TARGET TREATMENT
For treatment of larger skin surface areas. For intense spot treatment.
SIZE: 4 Treatment Vials (1.62 fl oz/48ml) SIZE: 1 Treatment Vial (0.4 fl oz/12ml)
Suggested Retail: $130 Suggested Retail: $55
USAGE: USAGE:
โข Apply to face, neck, dรฉcolletรฉ and breasts as โข Apply to wrinkles surrounding mouth,
treatment and preventative. upper lip, delicate eye area and forehead.
โข A one-month supply in four, 12ml vials with โข Use as intense treatment on age spots.
hygienic applicators.
โข Apply to stretch marks, scars and other skin
โข Apply twice daily, in the morning and imperfections.
before bed, prior to moisturizing.
โข Each bottle designed to last approximately 7-10 days.
16. PHASE 1
P L A N T S T E M C E L L S C I E N C E
ALL OVER TREATMENT
For treatment of larger skin surface areas.
SIZE: 4 Treatment Vials (1.62 fl oz/48ml)
Suggested Retail: $130
USAGE:
โข Apply to face, neck, dรฉcolletรฉ and breasts as treatment and preventative.
โข A one-month supply in four, 12ml vials with hygienic applicators.
โข Apply twice daily, in the morning and before bed, prior to moisturizing.
โข Each bottle designed to last approximately 7-10 days.
17. PHASE 1
P L A N T S T E M C E L L S C I E N C E
TARGET TREATMENT
For intense spot treatment.
SIZE: 1 Treatment Vial (0.4 fl oz/12ml)
Suggested Retail: $55
USAGE:
โข Apply to wrinkles surrounding mouth, upper lip, delicate eye area and forehead.
โข Use as intense treatment on age spots.
โข Apply to stretch marks, scars and other skin imperfections.
18. PHASE 2
P L A N T S T E M C E L L S C I E N C E
NUTRACEUTICAL
FIBER SACHETS
INTERNAL
SIZE: 30 Sachets
INGREDIENTS: Coneflower, Baobab Fiber
KEY CLAIMS
โข Daily consumption helps decrease oxidative stress damage
and limit inflammation.
โข Fiber helps cleanse and purify the body, thus allowing maximum
absorption of the plant stem cells.
โข Nourishes skin.
USAGE TIPS:
โข Add to water, juice or any other liquid and drink daily.
โข Add to room temperature or cooler liquids only
for maximum efficacy.
19. โข Cosmetic products formulated to add turgidness to lips
โข Cosmetic products formulated to fight enlarged pores
PL ANT STEM CELL SCIENCE INGREDIENT โข Cosmetic products formulated to reduce the cellulite
Subjects undergoing the trial:
Nr 30-60 subjects, age: 18 โ 60, sex: M/F. possibly represen
CLINICAL STUDY OF EDELWEISS Criteria of volunteers selection:
Good health condition
No participation in analogous trials in the two previous mo
PROTOCOL
Negative anamnesis for allergenic skin reactions
Absence of skin pathologies
Absence of topic pharmacological treatment in progress
โ Every volunteer is given a form to fill in and subscribe, in o
to the above mentioned conditions.
Every volunteer is given a form to fill in and subscribe in order to e
โข 20 subjects ages 35-65 that no condition of test exclusion is present.
Experimental procedures: one of the following experimental proce
โข Study featured both qualitative and instrumental methodology
Before, during and after the treatment
Positive control or market benchmark of proven efficacy
Comparison among differently formulated products
โข Applied product with 1% Edelweiss twice per day
Instrumentation
The measurement is carried out by DERMATOP BLUE (EOTECH, F
โข Skin was measured at onset of test, at 22 days and at 40 days
DERMATOP BLUE is a skin scanner to perform tests for the evaluat
results obtained evaluating the volunteers at time 0 and after the tre
โข Used state-of-the-art Dermatop Blue Scanner
The
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20. PL ANT STEM CELL SCIENCE INGREDIENT
CLINICAL STUDY OF EDELWEISS
EYE CONTOUR
โข Used Blue Light Technology
โข Two of the subjects most representational of the effects
SUBJECT
Before the Treatment After 22 days of application After 40 days of application
15% IMPROVEMENT 18.3% IMPROVEMENT
23. P L A N T S T E M C E L L S C I E N C E
IN SUMMARY
1. Highest blended potency
2. Maximum efficacy
3. Greenest Quality
24. P L A N T S T E M C E L L S C I E N C E
R E V I T A L I Z E R E J U V E N A T E R E S T O R E
EDELWEISS CONEFLOWER PENNYWORT
(Leontopodium Alpinum) (Echinacea Angustifolia) (Centella Asiatica)
A n Eco-brea kt h rou gh in A nt i-A ging Skin Scie nc e:
Ble n d i n g Pla nt St e m C e lls for M a x i m u m Effic a c y
S E P T E M B E R 2 011
