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TRANSFORMING HEALTHCARE 
THE 
QUANTIFICATION OF 
EVERYTHING 
STEVEN TUCKER, MD, FACP, FAMS 
Global Health Advisor, SingTel 
Founder, Tucker Medical
WARNING ! 
We tend to overestimate 
the effect of a technology 
in the short run and 
underestimate the effect 
in the long run. 
Roy Amara 
Co-founder, Institute for the Future
1 
EXPONENTIALS
1974 1984 1994 2004 2014 EXPONENTIALS 
4E+09 
3E+09 
2E+09 
1E+09 
4E+03
4E+09 
3E+09 
2E+09 
1E+09 
4E+03 
COMPUTING 
POWER 
1974 1984 1994 2004 2014 2024
4E+09 
3E+09 
2E+09 
1E+09 
4E+03 
MOORE’S 
LAW 
1974 1984 1994 2004 2014 2024
Computers 
4E+09 
3E+09 
2E+09 
1E+09 
4E+03 
MOORE’S 
LAW 
1974 1984 1994 2004 2014 2024
Computers 
4E+09 
3E+09 
Sensors 
2E+09 
1E+09 
4E+03 
MOORE’S 
LAW 
1974 1984 1994 2004 2014 2024
Computers 
4E+09 
3E+09 
Sensors 
2E+09 
1E+09 
4E+03 
MOORE’S 
LAW 
Biology 
1974 1984 1994 2004 2014 2024
Computers 
4E+09 
3E+09 
Sensors 
2E+09 
1E+09 
4E+03 
MOORE’S 
LAW 
Biology 
Pan-omics 
1974 1984 1994 2004 2014 2024
2 
PROBLEMS
Healthcare is not 
a science problem, 
it’s an information 
problem. 
-Thomas Goetz
DIABETES 
382 Million 
Source: International Diabetes Federation
OBESITY 
500 Million 
Source: World Health Organisation
HEART DISEASE 
17.3 Million 
Source: World Health Organisation
CANCER 
14.1 Million 
Source: World Health Organisation
3 
SENSORS
If you cannot 
measure it, you 
cannot improve it. 
-Lord Kelvin
SENSOR 
EVOLUTION 
Sensor 1.0 
Sensor 2.0 
Sensor 3.0 
Ability to measure 
+ record signal 
Sensor web 
integration; share 
+ access data 
Passive data 
gathering + 
aggregating + 
meaningful insight
ACTIVITY
HEALTH
MEDICAL
THE TRICORDER
VITAL SIGNS
EMERGENCY
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
BIRTH CONTROL
WIRELESS 
BIRTH CONTROL
4 
BIOLOGY
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
THERANOS
RETAIL LABS
HOME TRACKING
HOME DIAGNOSIS
HOME DIAGNOSIS
LAB ON A CHIP
CELL CAPTURE
LIQUID BIOPSY
Transforming Healthcare: The Quantification of Everything
GENOME MATH 
23Pairs of 
chromosomes
GENOME MATH 
20k Genes
GENOME MATH 
4Bases 
A - T 
G - C
GENOME MATH 
3.2 
Base pairs 
per genome 
billion
GENOME MATH 
3.2billion 40xCoverage BP 128billion 
data points
SEQUENCING $
GENOMICS 2001
GENOMICS 2007
GENOMICS 2013
GENOMICS 2014
GENOMICS 2014
GENOMICS 2016
GENOMICS 2018
Transforming Healthcare: The Quantification of Everything
NEXT GEN 
SEQUENCING
NEXT 
NEXT GEN 
SEQUENCING ?
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
5 
PLATFORMS
Transforming Healthcare: The Quantification of Everything
$2.4 
Billion
$26 
Billion
SENSORS
SENSORS 
Gyroscope Proximity
SENSORS 
Gyroscope 
Proximity 
Gesture 
Fingerprint
SENSORS 
Gyroscope 
Proximity 
Gesture 
Compass 
Fingerprint 
Hall cover
SENSORS 
Gyroscope 
Gesture 
Heart rate 
Proximity 
Compass 
Barometer 
Fingerprint 
Hall cover
SENSORS 
Gyroscope 
Gesture 
Ambient light 
Heart rate 
Accelerometer 
Proximity 
Compass 
Barometer 
Fingerprint 
Hall cover
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
6 
PAN-OMICS
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Exposome 
33 
48 
Cd 
80 
Hg 
28 
Ni 
81 
82 
Ti 
Pb 
As
EPphigeennoommee
! 
TRANSFORM
Digital Health as 
Google Map 
HEALTH AS A 
GOOGLE MAP 
SENSOR 
ACTIVITY 
DIET 
GENOME 
MICROBIOME 
LAB 
PHENOME 
UNIQUE 
PERSON
Digital Health as 
Google Map 
HEALTH AS A 
GOOGLE MAP 
SENSOR 
ACTIVITY 
DIET 
GENOME 
MICROBIOME 
LAB 
PHENOME 
UNIQUE 
PERSON
6P4 
MEDICINE
P4 MEDICINE 
1. Predictive 
2. Preventive 
3. Personalized 
4. Participatory
100k WELLNESS 
PROJECT 
1. Predictive 
2. Preventive 
3. Personalized 
4. Participatory
P4 MEDICINE 
Predictive 
You will track your health. 
It’s your data. 
Identify transition states.
P4 MEDICINE 
Preventive 
Wellness networks. 
Illness networks. 
A systems-based approach 
to repair and maintenance.
P4 MEDICINE 
Personalized 
You are your own control. 
Your health data cloud. 
Molecular + Environmental.
P4 MEDICINE 
Participatory 
Transformative for health. 
Societal change - enormous. 
Patients will adapt. 
Doctors may adapt?
THE PIVOT 
Health Status 20% of patients = 
80% of costs 
Healthy 
Low Risk At Risk High 
Risk 
Chronic 
Disease 
Early 
Active 
Disease 
End of Life 
Care 
Chronic 
Disease 
Progression 
VALUE COST
6 
LONGEVITY
Transforming Healthcare: The Quantification of Everything
Life Expectancy at birth 
85 
82 
79 
76 
73 
70 
1990 2000 2008 1990 2000 2008 1990 2000 2008 1990 2000 2008 
< 12 12 13-­‐15 > 16 
Years of Educa>on
TECHNOLOGY
BIOLOGY
Transforming Healthcare: The Quantification of Everything
CALICO
7 
AND…
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
Transforming Healthcare: The Quantification of Everything
THANK YOU 
For your 9me & a>en9on

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