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Ventilation and Perfusion in different zones of lungs.

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Ventilation and Perfusion in different zones of lungs.

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This powerpoint presentation will make you explore about the Perfusion and Ventilation in different zones of lungs with its co-relation with pulmonary tuberculosis.

This powerpoint presentation will make you explore about the Perfusion and Ventilation in different zones of lungs with its co-relation with pulmonary tuberculosis.

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Ventilation and Perfusion in different zones of lungs.

  1. 1. Gandaki Medical College By: Gyaltsen Gurung
  2. 2. To define and classify ventilation and perfusion in lungs. To describe zone of perfusion in lungs To describe ventilation perfusion ratio in lungs To correlate VENTILATION and PERFUSION ratio with PULMONARY TUBERCULOSIS OBJECTIVES
  3. 3.  VENTILATION The rate at which air enters or leaves the lungs.  Types : i) Pulmonary Ventilation ii) Alveolar Ventilation 1)Pulmonary Ventilation (minute ventilation or respiratory minute volume): Is the volume of air moving in and out of respiratory tract in a given unit of time during quiet breathing. INTRODUCTION
  4. 4.   Pulmonary Ventilation= Tidal volume X Respiratory Rate = 500 ml x 12/minute = 6000 ml/minute 2) Alveolar ventilation: It is the amount of air utilized for gaseous exchange every minute. Alveolar ventilation = (Tidal volume – Dead space) X Respiratory Rate = ( 500 – 150 ) ml x 12/minute = 4200ml/minute TYPES OF VENTILATION.....
  5. 5.   PERFUSION: The movement of blood into the lungs through pulmonary capillaries.  VENTILATION/PERFUSION RATIO : It is the ratio of alveolar ventilation and the amount of blood that perfuse the alveoli. Mathematically, V/Q = 0.84 VENTILATION AND PERFUSION
  6. 6.  ZONES OF LUNGS
  7. 7.  Zone 1: No blood flow Reason: More negative intrapleural pressure alveoli size↑ & lower arterial pressure due to gravity → decrease diameter of vessels  Zone 2: Intermittent blood flow Reason: arterial pressure is greater than alveolar and venous pressure. Whereas, venules pressure are less than alveolar pressure  venules are collapsed Zone 3: Continuous blood flow Reason: Due to gravity, there is high pressure → vasodilation → more blood flow ZONE OF PERFUSION
  8. 8.  Ventilation and Perfusion (5ml/minute) (0.56ml/minute) (10.3ml/minute)
  9. 9. Zone 1: 1.92 L/minute Reason: Increase size of alveoli Zone 2: 4 L/minute Reason: intermittent size of alveoli Zone 3: 6.5 L/minute Reason: Decrease size of alveoli ZONE OF VENTILATION
  10. 10.  It is the ratio of alveolar ventilation and the amount of blood that perfuse the alveoli. Calculation: V/Q= alveolar ventilation ÷ pulmonary blood flow Alveolar ventilation= 4200ml/minute Pulmonary blood flow=5000ml/minute So, V/Q= 0.84 Ventilation/Perfusion (V/Q) Ratio
  11. 11.  V/Q RATIO IN LUNGS
  12. 12.  Zone 1: Ventilation(V) >>> Perfusion(Q) V/Q= 3.4 (high) Zone 2: Ventilation(V) = Perfusion(Q) V/Q= 0.8 (average) Zone 3: Perfusion(Q) >>> Ventilation(V) V/Q=0.63(low) V/Q IN DIFFERENT ZONES OF LUNGS
  13. 13. Apical Zone of lungs : It is more infected by Pulmonary Tuberculosis Reasons: i) There is low perfusion. ii) There is higher V/Q , higher PO2 and lower PCO2 (M.tubercle is strict aerobes) iii) Less of the oxygen is carried away by the blood in apex of lungs. ( Highest O2 available) V/Q and PULMONARY TUBERCULOSIS
  14. 14. Zone 1: Ventilation(V) >>> Perfusion(Q) V/Q= 3.4 (high) Zone 2: Ventilation(V) = Perfusion(Q) V/Q= 0.8 (average) Zone 3: Perfusion(Q) >>> Ventilation(V) V/Q=0.63(low) Apex: It is more infected by Pulmonary Tuberculosis because SUMMARY
  15. 15.   Guyton and Hall ( 13th edition) Text Book of Medical Physiology  K Sembulingam and Prema Sembulingam(6th edition) Essentials of Medical Physiology  Ananthanarayan and Paniker’s( 9th edition) Text Book of Microbiology REFERENCES
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