Heart disease is the number one killer worldwide. It is caused by a buildup of fatty deposits called plaque in the coronary arteries that supply blood to the heart. This buildup is known as atherosclerosis. Risk factors include age, family history, high cholesterol, smoking, high blood pressure, diabetes, obesity, physical inactivity, and excessive alcohol use. Indians are especially susceptible due to genetic factors and adopting unhealthy lifestyles. To prevent heart disease, one should eat a healthy diet low in fat and cholesterol, exercise regularly, avoid smoking, monitor cholesterol and blood pressure levels, and take medication as prescribed. Maintaining a heart-healthy lifestyle can help prevent heart disease and its complications.