1. Brain Chemistry and the Medical Treatment of Major Depression William J. Giakas, M.D.

11. Serotonin and Behavior 5-HIAA LO Impulsivity HI

12. Serotonin Pathways

15. Tricyclic Antidepressants TCA Α 1,2 M1 NRI H 1,2 SRI

22. Focus of Research in Depression Neurotransmitters Surface Receptors Intracellular Signaling Cascades

24. Temporal Lobe and Hippocampus

27. Potential Mechanisms of Cell Loss and Atrophy Glucocorticoids Neurotrophic Factors Glutamate

33. Intracellular Signaling Source: Manji HK, Quiroz JA, Gould TD (2003)

38. Electroconvulsive Therapy

43. High Dose vs. Low Dose Unilateral vs. Bilateral Sackeim, et al, Arch Gen Psych, June 2000

44. Seizure Suppression EMG EEG

45. AD vs. ECT + AD Gagne et al., Am J Psych, Dec 2000