Dedicated to Dr. Murray E Fowler Legacy
3rd GRF ONE HEALTH SUMMIT Davos, Switzerland 2015
BORRELIA IN BRAZIL AND CO-INFECTIONS – “FACT OR FICTION”? - A
RESEARCH COLLABORATIVE STUDY WITH A ONE HEALTH APPROACH
Klaisy Christina Pettan-Brewer, MV, DVM, MSc* 1, 2, Patricia da Fontoura
Rodrigues, MV3, Antonio Carlos Bandeira, MD4, Paulo Eduardo Neves Ferreira
Velho, MD, DSc5, Maria Otavia Crepaldi, PhD6, Luis Augusto Nero, MV, DSc2,
Tarcizio Antonio R de Paula, MV, DSc2, Maria Aparecida Scatamburlo Moreira, MV,
DSc2 , Natalino Yoshinari, MD 6, Ueti Massaro, MV, PhD6 and Troy Bankhead, PhD 7
1 School of Medicine, University of Washington, Seattle, 98195 USA; 2 School of
Veterinary Medicine and One Health, One World Brazil-Latin America, University
Federal of Viçosa, Minas Gerais, 36570 Brazil, Animal Hospital and PR
Agropecuaria Ltda, Porto Seguro, Bahia, 45810 Brazil; 3 Hospital Aliança, Infectious
Diseases Sector, Salvador, Bahia, 40015 Brazil,4 School of Medicine, University of
Campinas, Sao Paulo5 , University of Sao Paulo6 and USDA and Paul Allen Global
Animal Health, School of Vet Med Washington State University, Pullman, USA7

Universidade Federal de Viçosa, Minas Gerais VET 1983-1988
2012 – Universidade Federal de Viçosa, Minas Gerais _ ONE HEALTH Proposal

9/11/13
9/13/13
MOU – MEMORANDUM OF UNDERSTANDING – DUAL DEGREE ONE HEALTH

Centers of Excellence for ONE HEALTH in Brazil
ONE HEALTH
UFV OFFICE
Minas Gerais
Bahia
Pernambuco
Piaui
Roraima
Rondonia..
UW/WSU
• UFMG
• UFP
• USP
• UNESP
• UNICAMP
• USDA
• EMBRAPA
• ...
ONE WORLD,ONE HEALTH
*Colombia and Peru CEOH
*
*
JUNE 2015
2013

Antibiotic Resistance
Food Production
Microbiome and Probiotics
Water and Health – Cryptosporidium
EID and Neglected ID
NCD AND NUTRITION
*dom. and wild animals as sentinels

ONE HEALTH, ONE WORLD
Human
Animal
Environment
“Between animal and human medicine there is no dividing line – nor should be.
The object is different but the experience obtained constitutes the basis of all medicine.
Rudolf Virchow” (1800’s)
USA Fulbright Scholar Award
March – June 2015 (UFV)
First accredited class in the L.A .curriculum – interdisciplinary
CLINICA MEDICA
October 2015 _ Brazil

RADIO IDARON
Public Health Agents
Centers of Excellence
for ONE HEALTH in
Brazil - RONDONIA

Centers of Excellence for ONE HEALTH in Brazil – PIAUI

Centers of Excellence for ONE HEALTH in
Brazil – BAHIA
OH Porto Seguro
March 2015
One health experience value and inclusive

BORRELIA IN BRAZIL AND CO-INFECTIONS – “FACT OR
FICTION”? - A RESEARCH COLLABORATIVE STUDY
WITH A ONE HEALTH APPROACH
BRAZIL _ LATIN AMERICA 2012
2014-2015 SCHOLAR AWARD FOR ONE HEALTH

ONE HEALTH (Human-Animal-Environment) USA/BRAZIL Institutional,
Interdisciplinary Partnership Collaborative Program 2014 - CLINICAL physicians,
veterinarians, nurses, anthropologists, wildlife biologists and SCIENTISTS
collaboration
Research Proposal - Neglected and Emerging Infectious Tropical Diseases focusing on
Vector-Borne Diseases particularly in the complex Co-Infection by microorganisms in
the genera Borrelia and Rickettsia, Ehrlichia, Bartonella, Anaplasma and Babesia -wildlife as
reservoirs and sentinels
by KCPB and Dr. Patricia Rodrigues (One Health Brazil – Bahia)

PATAXOS (Aldeia Velha)

Pettan-Brewer, C. Rodrigues , P. et al, 2016, Co-Infection by microorganisms in the genera Borrelia in Brazil (probably mutations
or unknown sp) and Ehrlichia, Bartonella and Babesia or a new EID – with the ONE HEALTH concept .
Animals as sentinels

Livestock and sustainable development

EID Emerging Infectious Diseases
Habitat destruction and human
Encroachment
Wildlife as reservoirs?
Occupational Hazardous ?
Vector Borne DZ – which one (s)?

Wild Animals Blood Bank – BRAZIL
CETAS – Wildlife rehabilitation centers
Primates, Rodents, Birds, Local Fauna
Wild Felids and canids, Opossuns,reptiles
HUMAN SAMPLES
and patient care at
SUS & CEOH systems
UFV MG
BAHIA

2015 BORRELIA FACTS
• Brazilian Lyme disease-simile illness or Bagio-Yoshinari
Syndrome (BYS) has been described since 1990’s – it
does not have EM either in humans or animals
• 2007 (Mantovani et al) unable to confirm if BYS is caused
by new Borrelia or related to genetically modified
Borrelia burgdorferi sensu lato or other infectious agent
or unidentified spirochete
• No IXODES in Brazil, but other vectors, especially
Amblyoma – which Relapsing Fever has been reported
in the USA

2015 FACTS
 8-10 MONTHS to have permits from the Human Ethics
Committee – Brazil on strikes (financial and political)
 Over 8-10 months to receive local government permits
to transport biological materials – DNA samples finally
released after intense bureaucracy - CDC/USDA okay
 Airports far away or usually hours of overnight drive to
main cities
 (REAL crisis) even if there is funding (NIH-WSU), there is no
way how to send at the administrative level unless
exhaustive international academic bureaucracy
 Economic Recession – no longer Brazilian government’s
grants and CUTS FOR EDUCATION, HEALTH AND
RESEARCH
 Climate and Environmental CHANGES

Conclusion ?
Fiction or Fact
 pathogen may be more phylogenetically related to
relapsing fever Borrelia than Lyme disease Borrelia
This may be why we see clinical symptoms relating to both types, but cannot
identify using only diagnostic tests designed for Lyme disease type species.
 Once cultured and identified (currently research at
Borrelia LAB @ WSU – establishing lab in Brazil), we will
develop new kits to effectively diagnose the disease in situ
and Labs in BRAZIL – meanwhile partnership groups with
ONE HEALTH concept (CEOH - Brazil).
 Two Borrelia species that also cause a “Lyme disease-like
syndrome” would be B. miyamotoi and B. lonestari.
These two have also been incredibly difficult to culture until only very recently
Borrelia braziliensis , B fontouraferi

http://www.onehealth.ufv.br
 FACEBOOK – One Health, One World Brazil – Latin America
 Dual PhD Degree and MSc in ONE HEALTH – UFV and WSU/UW
 Other One Health Groups in Latin America and the World – Global Health
 Long term and sustainable academic and research partnerships with the
ONE Health Concept is very successful – “collaboration rather than competition”
 Intellectual Property agreements between countries are signed respected
 MOU between Brazilian Federal Associations of Medicine and Veterinary Medicine
 Continue spreading the concept human-animal-environment
 Continue Academic Training and Improving Labs in local areas
 Help from higher organizations such as WHO, OIE, FDA,
This is to certify that
JADER LUCIO PINHEIRO SANT ’ANA
has attended the accredited course ONE HEALTH : Interdisciplinary aspects for reducing risks of
diseases at the animal-human-ecosystems interface, from June 8th to 12th, 2015 at University Federal
of Viçosa, Minas Gerais, Brazil, in a total of 20 hours equivalent of 2 continuing education credits.
Luís Augusto Nero
Coordinator of the Graduate Program in
Veterinary Medicine, UFV
Josefina Bressan
Coordinator of the Graduate Program in
Nutrition Science, UFV
K Christina Pettan Brewer
Fullbright Scholar
University of Washington

THANK YOU
"In the long history of humankind (and
animal kind, too) those who learned to
collaborate and improvise most effectively
have prevailed." Richard Dawkins