BBAU

1. GOVIND YADAV
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2.  INTRODUCTION
 EVALUATION OF TABLET
Non-official Tests:
1) General appearance
I) Organoleptic property
II) Size & Shape
2) Hardness
3) Friability
Official tests:
1) Weight Variation
2) Content uniformity
3) Dissolution
4) Disintegration
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3. Tablets:-
Tablets are the solid unit dosage forms
containing a medicament or mixture of medicament
& excipients compressed or moulded into solid .
TYPE OF TABLETS :-
I) Compressed tablets
Ex: Coated & Uncoated tablets.
II) Molded tablets
Ex: Dispensing & Hypodermic tablets.
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4. .
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5. The general appearance
of a tablet, its visual identity and overall “elegance”
is essential for consumer acceptance, for control of
lot-to-lot uniformity
Appearance of a tablet involved the measurements
of a tablet’s:-
 Size
 Shape
 Colour
 Odour
 Taste
 Surface texture
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6.  Many pharmaceutical tablets use color as a
vital means of rapid identification and
consumer acceptance
 The color of a product must be uniform
within a single tablets
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7. Caliper scale 7

8.  Tablets require a certain amount of strength, or
hardness and resistance to friability, to withstand
mechanical shocks of handling in manufacture,
packing and shipping
 Hardness thus sometimes termed the tablet
crushing strength
 Tablet hardness tester are:-
 Monsanto tester
 Pfizer tester
 Strong-cobb tester
 Erweka tester
 Scleuniger tester
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10.  The friability test is official in USP but not in BP
and IP
 Friability tester is known as the Roche friabilator
 Tablet hardness is not an absolute indicator
of strength since some formulations,when
compressed into very hard tablets
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11. Roche friabilator
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12.  The weight of the tablet being made is
routinely measured to help ensure that a tablet
contains the proper amount of drug
 As per indian pharmacopoeia (IP)
weight 20 tablets selected at random and
determine the average weight
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14.  The potency of tablets is expressed in the
terms of grams, milligrams, or micrograms of
drug per tablet and is given as the label
strength of the product
 Determine the amount of active ingredient by the
method in the Assay;
 The result lies within the range for the content of
active ingredient stated in the monograph
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15.  This test is applicable to tablets that contain
less than 10mg or less than 10% w/w of the
active ingredient
 It is not applicable to tablets containing
multivitamin and trace element
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16.  Ten tablets are taken at random, there
content of active ingredient is determine in
each of 10 tablets and the average value is
calculated
The sample passes the test is not more than one of
the individual value is the out side the limit of 85
to 115% of the average value 16

17.  If two or three of the individual tablets are
outside limits 85 to 115% of the average value
and the none is the outside the limit 75 to 125%
The test is repeated using another
20 tablets 17

18.  In the total sample of 30 tablets
Not more than three of the individual values
are outsides the limit 85 to 115% and none is
outside the limits 75 to 125% of the average
value
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pharmacopoeia

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