1.
Pain and Plantar Fascitis

2.
Microtrauma
Activation of
Nociceptive
receptors
Tissue damage

3.
Pain Mediators
Damaged tissue
Proteases
ATP
K+

4.
Pain Mediators
Damaged tissue
Proteases
ATP
K+
Causes production of
bradykinin which can
directly depolarize the
nociceptors

5.
Pain Mediators
Damaged tissue
Proteases
ATP
K+
Causes production of
bradykinin which binds
to a nociceptor
Nociceptor
depolarization

6.
Pain Mediators
Damaged tissue
Proteases
ATP
K+
Causes production of
bradykinin which binds
to a nociceptor
Nociceptor
depolarization
Nociceptor
depolarization

7.
Pain Mediators
Damaged tissue
Proteases
ATP
K+
Activation of
Nociceptive receptors

8.
Transduction