Combinatorial chemistry is a technique used to rapidly produce large numbers of similar drug molecules to screen for new drugs more efficiently. It uses solid-phase synthesis with resins, monomers, and linkers under the same reaction conditions to generate compound libraries. This allows companies to increase their chances of finding novel therapeutic compounds and save time and money compared to traditional drug discovery methods. While efficiency depends on factors like compound size and solubility, combinatorial chemistry is expected to continue significantly impacting drug manufacturing.

2.  Combinatorial Chemistry is a new method developed by
academics and researchers to reduce the time and cost
of producing effective, marketable and competetive new
drugs.
 Scientists use Combinatorial Chemistry to create large
numbers of molecules that can be detected efficiently.
 This technique has captured the attention of many
areas such as Pharmaceutics, Biotechnology and
Agrochemistry.

3.  Combinatorial chemistry is a technique by
which large numbers of different but
structurally similar molecules are produced
rapidly and submitted for pharmacological
assay.
 This technique uses the same reaction
conditions with the same reaction vessels to
produce a large range of analogues.

4.  Applications of combinatorial chemistry are
very wide. Scientists use combinatorial
chemistry to create large populations of
molecules that can be screened efficiently en
masse. By producing larger, more diverse
compound libraries, companies increase the
probability that they will find novel
compounds of significant therapeutic and
commercial value.

5.  Solid-phase synthesis
 Resins
 Reagents(Monomers)
 Linkers
 Screening

6.  Saves time
 Rapid process
 Produces unexpected new compounds
 Biological and Chemical applications
 Saves money

7.  Efficiency is highly affected by compound's
size, solubility and function group.
 Compounds produced tend to be Achiral of
Racemic

8.  20 years ago the market for pharmaceuticals
was growing at around 10% per annum but
recently it has declined. At the same time,
costly pharmaceutical researches have
limited the methods to discover new
molecules.

9.  It is speculated that Combinatorial Chemistry
will allow the productive and cost-efficient
generation of compounds and drug
molecules, therefore
 Combinatorial chemistry will continue to
make a major impact on drug manufacture.

10.  http://www.combichemistry.com/combichem_
applications.html
 http://en.wikipedia.org/wiki/Combinatorial_ch
emistry
 http://www.wiziq.com/tutorial/2967-
Combinatorial-Chemistry-and-Library-Design
 http://www.netsci.org/Science/Combichem/fe
ature02.html
 http://www.chem.msu.su/rus/books/patrick/p
art1.pdf

11.  Jehan Essam Mahmoud
 Aya Ahmed Saber
 Eman Alaa Elshamy
 Eman Mohamed Sherra
 Aya Samir