1. Colonoscopy, virtual colonoscopy, capsule endoscopy European School of Oncology Rome, Italy Dr James East Consultant Gastroenterologist, John Radcliffe Hospital 12 April 2011

4. “ Hot button” issue – Cancer prevention Distal rectum and sigmoid: HR 0.50 (0.42-0.59) Proximal colon: HR 0.97 (0.80–1.17)

5. Colonoscopy outcomes Baxter NN et al. Ann Intern Med. 2009; 150 :1-8. Baxter NN et al. Gastroenterology 2011; 140 :65–72

6. Adenoma detection and interval cancer Kaminski MF et al. N Engl J Med 2010;362:1795-803

7. Proximal serrated lesion detection Adenoma and proximal serrated polyp detection correlated R=0.76, P<.001 Kahi CJ et al . Clin Gastro Hep 2011; 9 :42–46 Hetzel JT et al. Am J Gastroenterol 2010; 105 :2656–2664

9. CT colonography in nationwide practice France, n=845, 22 centres 1 of 9 cancer missed – diagnostically unacceptable scan Heresbach D et al. Gut 2010.doi:10.1136/gut.2010.225623 [E-pub] Mulhall BP et al. Ann Intern Med 2005; 142 :635-50. Mulhall meta analysis 85% (79 to 91)

10. CT colonography performance Conclusions: Radiologist sensitivity CTC for detection of polyps ≥ 6 mm in training was the sole independent predictor for subsequent sensitivity in detection of such polyps

13. Colon capsule Van Gossum A et al. N Engl J Med 2009; 361 :264-70 Sacher-Huvelin S et al. Aliment Pharmacol Ther 2010; 32 :1145–1153

16. Serrated lesions and follow up colonoscopy Schreiner M et al. Gastroenterology 2010; 139 :1497–1502

17. Serrated lesions and follow up colonoscopy Schreiner M et al. Gastroenterology 2010; 139 :1497–1502

18. Serrated lesions and follow up colonoscopy Schreiner M et al. Gastroenterology 2010; 139 :1497–1502