1.
Epidemiology and Public Health
Human and Animal Health Unit
Understanding zoonoses impacts:
The added value from One Health
approaches
Jakob Zinsstag

2.
5. April 2016 Präsentationstitel 2
„One Health“ requirements
Necessary (but not sufficient)
– Recognition of intextricable
linkage of human and animal
health
Sufficient:
– Added value of health and
wellbeing of humans and animals
and/or financial savings from a
closer cooperation of human
and animal health.

3.
5. April 2016 Präsentationstitel 3
Courtesy: Dr. Jan Kolar, Prague
Is it profitable to mass vaccinate 25 million sheep, goat and
cattle in Mongolia to prevent human brucellosis?

4.
05.04.2016 4

5.
Synoptic view of benefits and costs of animal brucellosis mass
vaccination in Mongolia
Distribution of Benefits
0
5000000
10000000
15000000
20000000
25000000
30000000
Intervention
cost
Public
health
benefits
Private
health
benefits
Household
income
loss
Total Health
Benefits
Agricultural
Benefits
Total
Societal
Benefits
Sector
US$

6.
5. April 2016 6
s dog mass vaccination less costly
han human post-exposure prophylaxis
o control human rabies?

7.
7
Simplified deterministic model of rabies transmission
between dogs and humans
S
R L
I
YX Z
βIS
λ δ σ
γ
αIX π κ
b1
b2
μ2
μ1 μ1
ρ
Dogs
Humans
S = susceptible dogs
L= latent infected dogs
I= rabid dogs
R= vaccinated dogs
X= susceptible humans
Y= exposed humans
Z = rabid humans
μ2

8.
85. April 2016 8
Comparative profitability of rabies control
in N‘Djaména
(Zinsstag et al. PNAS 2009, 106(35) 14996–15001
Human vaccination alone
Dog and human vaccination

9.
Infected humans / infected animal in selected zoonoses
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10.
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www.ecohealth.net