Now, more than ever before, is the time to address the autoimmune disease epidemic. With the convergence in science, tech, and patient demand, we can begin pieces the autoimmune puzzle together. With emerging tech, platforms and tools can improve care delivery. With your help, we can save millions.

1. © 2016 - All rights reserved.
Reversing the Invisible Epidemic of
Autoimmune Disease
DIY Comes to Autoimmunity
Your Autoimmunity Connection
+1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360

2. © 2016 - All rights reserved.
My Role: A=acking the Autoimmune Epidemic
A huge, growing and untapped market opportunity > CVD + Cancer
Obscured by staLsLcal gaps, scaMered across mulLple body parts and specialLes
A big, expensive, underappreciated part of the chronic disease epidemic
The @me is now to tackle this invisible epidemic!
DrBonnie360’s Services
• Converging science, technology, paLent demand
• New R&D: -omics, immunology, systems biology, root-cause
• IT infrastructure: ubiquitous smart mobile, API/Cloud, WWW
• Emerging autoimmune communiLes, demand (e.g. diet)
• Emerging technology pla_orms
• Point soluLons in diabetes and obesity show how lifestyle
modificaLons can improve quality of life and save money.
• New pla_orms, portals, communiLes are beginning to scale
health, wellness and prevenLon.
• Advances in technology provide tools to improve care delivery
Corporate Strategy
Business Development
Community Development
CommunicaLons & Design
MarkeLng & Sales

3. © 2016 - All rights reserved.
Huge & Growing Unmet Need
50 Million (16%)
Americans with
Autoimmune Diseases
• 1 in 6 Americans
• PopulaLon of 25 states
• > CVD + Cancer
100 +
autoimmune diseases
A Top 10
cause of death in
women < 64 yo
IBD incidence
Doubled
children < 10 yo
(1991-2002 )

4. © 2016 - All rights reserved.
Under-Recognized & Under-Researched:
16%
10%
6%
68%
US Pa@ent Popula@on
6%
24%
37%
33%
2014 NIH Grant Alloca@ons
Autoimmune Disease
Cardiovascular Disease
Cancer
Other

5. © 2016 - All rights reserved.
Untapped Market Opportuni@es
By 2023,
230 Million
Americans with chronic
diseases, cosLng
$4.2 Trillion
total treatment plus
economic output
$8/10
spent on health care
goes to chronic
diseases
27%
children <19 have at
least one chronic
condiLon
7/10 Deaths
Annually due to
chronic diseases
129% Increase
for specialty
autoimmune medicine
from 2011-2015
($20.9B – $47.9B)

6. © 2016 - All rights reserved.
Opportunity for Individualized Autoimmune Medicine NOW
Top-Down Convergence
Advances in technology and science provide tools for digital
individualized medicine:
2016
2015
2014
• Apple, Amazon, Google enter
healthcare market
• # of personal genomics
companies doubled
• Cleveland Clinic opens a
funcLonal medicine center
• Microbiome therapeuLcs
• Immuno-oncology
• Telemedicine & telehealth
• Virtual educaLon & digital
coaching
• IBM Watson, Apple
Healthkit
• AcLve M&A point
soluLons to pla_orms
• Cleveland Clinic begins
outcomes/cost clinical
trials
• Wellness as a Service

7. © 2016 - All rights reserved.
Need Individualized Autoimmune Medicine NOW
BoMom-Up Convergence
Autoimmune paLents desperately seeking earlier diagnoses
and sustainable treatments that address root causes
• Gaps in diagnosis & treatment
• Average: 3.5 years & 5 doctors to Dx
• 51% labeled chronic complainers
• More autoimmune than cancer
paLents with poor quality of life
• Rheumatoid arthriLs 87% vs.
Breast cancer 39%
Needs Trends
• Crowdsourcing, CiLzen Science and
maker movement
• Online community support groups
& growing paLent power
• QuanLfied Self, N=1 Clinical Trials,
experiments with diet & supplements
• Emergence of FuncLonal Medicine
programs in convenLonal serngs

8. © 2016 - All rights reserved.
-RemoteMonitoring
- Chronic Disease Marketplace/Platform
- Functional and Conventional Coordination
-Personalization
-Individualized
-DataCollection
REGENERATION
Bridging the Gap – Individualized Autoimmune Care

9. © 2016 - All rights reserved.
Contact Us
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/
YourAutoimmunityConnecLon
Bonnie Feldman, DDS, MBA
DrBonnie360’s mission is to create a
digitally connected world of personalized
care for autoimmune paLents.
We consult with start-up companies and
entrepreneurs who are bringing new
products and services that will improve
research, diagnosis, and treatment for
autoimmunity

10. © 2016 - All rights reserved.
Sources
• Huge & Growing Unmet Need
• 50 Million Americans & 100+ Autoimmune Disease – “Why is Auotoimmune Diseae Underserved,” DrBonnie360, Mar 2015.
hMp://bit.ly/1B57pNb
• Top 10 cause of death – AARDA Autoimmune Disease Fact Sheet. hMp://www.aarda.org/autoimmune-informaLon/
autoimmune-staLsLcs/
• Increasing Incidence in IBD – “Rising Incidence of Inflammatory Bowel Disease among Children: a 12-year Study,” Journal of
Pediatric Gastroenterology & NutriLon, Jan 2010. hMp://bit.ly/1Zeg3b6
• Under-recognized & Under-Researched
• 16% of the US PopulaLon is Autoimmune – AARDA Autoimmune Disease Fact Sheet. hMp://www.aarda.org/autoimmune-
informaLon/autoimmune-staLsLcs/
• <6% of NIH Funding goes to autoimmunity – “Health, United States, 2013 with Special Feature on PrescripLon Drugs,” Center
for Disease Control and PrevenLon, 2014. hMp://www.cdc.gov/nchs/data/hus/hus13.pdf#042
• Untapped Market Opportunity
• 27% of Children – “Chronic Care: Making the Case for Ongoing Care,” Robert Wood Johnson FoundaLon, Mar 2010.
• 7/10 Deaths – “Chronic Disease PrevenLon and Health PromoLon,” Center for Disease Control and PrevenLon, Aug 2016.
• 129% Increase – “Medicines Use and Spending in the U.S: A Review of 2015 and Outlook to 2020,” IMS InsLtute for Healthcare
InformaLcs, Apr 2016.
• $8/10 Dollars – “The Digital RevoluLon comes to US Healthcare,” Goldman Sachs, Jun 2015.
• 230M Americans cosLng $4.2T – “Checkup Time: Chronic Disease and Wellness in America,” Milken InsLtute, Jan 2014.