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BIIT
Inside Bioinformatics
Dmytro Fishman
Com
puter
Land
Science
Com
puter
Software
Engineering
MSc
Land
Science
Com
puter
Software
Engineering
MSc
Science Land
Algorithms
canyon
City of Data Mining
Software
Development
area
Other Stuff
Wastelands
Pure Math
Endless Ocean The Dark Forest of
Biology
Statistics
Sea
Economics World
Let it be
chemistry
here
Com
puter Science Land
Algorithms
canyon
City of Data Mining
Software
Development
area
Other Stuff
Wastelands
Algorithms
canyon
Pure Math
Endless Ocean
Statistics
Sea
Economics World
Let it be
chemistry
here
Com
puter Science Land
The Dark Forest of
Biology
City of Data Mining
Software
Development
area
Other Stuff
Wastelands
Pure Math
Endless Ocean
Statistics
Sea
Economics World
Let it be
chemistry
here
Com
puter Science Land
The Dark Forest of
Biology
Algorithms
canyon
City of Data Mining
Software
Development
area
Other Stuff
Wastelands
Pure Math
Endless Ocean
Statistics
Sea
Economics World
Let it be
chemistry
here
Com
puter Science Land
The Dark Forest of
Biology
Algorithms
canyon
City of Data Mining
Software
Development
area
Other Stuff
Wastelands
Pure Math
Endless Ocean
Statistics
Sea
Economics World
Let it be
chemistry
here
Com
puter Science Land
The Dark Forest of
Biology
Algorithms
canyon
City of Data Mining
Software
Development
area
Other Stuff
Wastelands
DIMA’S INTERESTS LAND
WELCOME TO
DIMA’S INTERESTS LAND
WELCOME TO
DIMA’S INTERESTS LAND
AUTOIMMUNITY
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS
MEDICAL
IMAGING
WELCOME TO
DIMA’S INTERESTS LAND
AUTOIMMUNITY
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS
MEDICAL
IMAGING
AUTOIMMUNITY
Sample
ProtoarraySample
ProtoarraySample
ProtoarraySample
Protein1
ProteinN
Protein2
Patients Healthy
AUTOIMMUNITY
AIRE-Deficient Patients Harbor Unique High-Affinity
Disease-Ameliorating Autoantibodies (Meyer et al. 2016)
The Serological Autoimmunome of AIRE-
deficiency is Large and Comprises Two
Distinct Subgroups
Dmytro Fishman1, Kai Kisand2, Christina Hertel3, Mike Rothe3, Anu Remm2,
Maire Pihlap2, Priit Adler1, Hedi Peterson1, Jaak Vilo1, Aleksandr Peet4,
Antonella Meloni5, Katarina Trebusak Podkrajsek6, Tadej Battelino6, Øyvind
Bruserud7, Annette SB Wolff7, Eystein S Husebye7, Nicolas Kluger8, Kai
Krohn8, Annamari Ranki8, Adrian Hayday9, Pärt Peterson2
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS
MEDICAL
IMAGING
AUTOIMMUNITY
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS
MEDICAL
IMAGING
AUTOIMMUNITY
…AACCTGTTACAAACCG…
ON
OFF
FUNCTIONAL GENOMICS
…AACCTGTTACAAACCG…
ON
OFF
FUNCTIONAL GENOMICS
…AACCTGTTACAAACCG…
ON
OFF
FUNCTIONAL GENOMICS
…AACCTGTTACAAACCG…
…AGCCTGTTACAAACCG…
ON
OFF
ON
OFF
FUNCTIONAL GENOMICS
…AACCTGTTACAAACCG…
…AGCCTGTTACAAACCG…
ON
OFF
ON
OFF
FUNCTIONAL GENOMICS
…AACCTGTTACAAACCG…
…AGCCTGTTACAAACCG…
ON
OFF
ON
OFF
FUNCTIONAL GENOMICS
Input
Sequence
A
A
A
G
C
C
T
…AACCTGTTACAAACCG…
…AGCCTGTTACAAACCG…
ON
OFF
ON
OFF
FUNCTIONAL GENOMICS
Input
Sequence
A
A
A
G
C
C
T
A
C
T
G
Convolution
Convolution
Layer #1
Convolution
Layer #2
FC Layer
Deep learning for computational biology
Angermueller et al.
Predicted
Output
…AACCTGTTACAAACCG…
…AGCCTGTTACAAACCG…
ON
OFF
ON
OFF
87%
13%
FUNCTIONAL GENOMICS
A/G?
In collaboration with Kaur Alasoo (kauralasoo@gmail.com) &
Yurii Toma (yurii.toma@gmail.com)
FUNCTIONAL GENOMICS
Genome
Geenivaramu
Genome
Geenivaramu
Genome
Geenivaramu
Genome
Geenivaramu
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
MEDICAL
IMAGING
AUTOIMMUNITY
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
IMAGINGMEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
AUTOIMMUNITY
MEDICAL
IMAGING
Disease Stage Prediction
Diabetic Retinopathy
Sources of images are: kaggle.com and nature.com
MEDICAL
IMAGING
Heart Volume
Prediction
Heart Failure
Sources of images are: kaggle.com and nature.com
Disease Stage Prediction
Diabetic Retinopathy
MEDICAL
IMAGING
Cell Segmentation
Heart Volume
Prediction
Heart Failure
Disease Stage Prediction
Diabetic Retinopathy
MEDICAL
IMAGING
Cell Segmentation
Heart Volume
Prediction
Heart Failure
Disease Stage Prediction
Diabetic Retinopathy
Dmytro Fishman, Ardi Tampuu, William Jones, Elizabeth Bell, Ilya
Kuzovkin, Tanel Pärnamaa, Leopold Parts, Jaak Vilo, Raul Vicente
Mari-Liis Allikivi, Elena Sügis, Dmytro
Fishman
Anna Leontjeva, Ilya Kuzovkin, Dmytro Fishman
MEDICAL
IMAGING
???
0 1
0 1
0 1
0 1
0 1
90%
0 1
Dermatologist-level classification of skin cancer with
deep neural networks (Esteva et al., 2017)
90% VS 14%
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
MEDICAL
IMAGING
AUTOIMMUNITY
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
MEDICAL
IMAGING
AUTOIMMUNITY
MEDICAL
SIGNAL
MEDICAL
SIGNAL
Neuroimaging MEDICAL
SIGNAL
Neuroimaging EEG Signal MEDICAL
SIGNAL
Neuroimaging EEG Signal
Fourier
Transform
Data
MEDICAL
SIGNAL
Neuroimaging EEG Signal
Data
MEDICAL
SIGNAL
Neuroimaging EEG Signal
Data Machine Learning
MEDICAL
SIGNAL
MEDICAL
SIGNAL
Neuroimaging EEG Signal
Data Machine Learning
MEDICAL
SIGNAL
Neuroimaging EEG Signal
Data Machine Learning
Anna Leontjeva, Ilya Kuzovkin, Dmytro Fishman
https://github.com/kuz/BrainActivity3D
Cardiogram
Data Machine Learning
P( ) = .92
Cardiograph
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
MEDICAL
IMAGINGMEDICAL
SIGNAL
AUTOIMMUNITY
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
MEDICAL
IMAGINGMEDICAL
SIGNAL
AUTOIMMUNITY
AI
AI
Elena Sügis
Anna Ufliand
AI
Elena Sügis
Anna Ufliand
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
SIGNAL
TEACHING AND
GIVING TALKS A/G?
MEDICAL
IMAGINGMEDICAL
SIGNAL
AUTOIMMUNITY
WELCOME TO
DIMA’S INTERESTS LAND
FUNCTIONAL
GENOMICS
MEDICAL
IMAGING
TEACHING AND
GIVING TALKS
MEDICAL
SIGNAL
A/G?
AUTOIMMUNITY
BIIT
dmytro@ut.ee
What does it mean to be a bioinformatician?

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What does it mean to be a bioinformatician?