Depression is a debilitating mental illness that affects millions of people worldwide. While traditional antidepressants have been the standard treatment of choice for decades, they may not work for everyone. Ketamine, a drug that has been used as an anesthetic for decades, has shown promise as a fast-acting antidepressant in recent years. As a result, researchers are investigating the use of ketamine for depression extensively. This article explores what ketamine is, how it works, its history in treating depression, and its potential as a treatment option. We will also examine the different ways ketamine is delivered, potential side effects, and how it compares to traditional antidepressants.