The UK YellowCard by @MHRApress

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The MHRA and the Commission on Human Medicines (CHM) run the UK’s spontaneous adverse drug reaction (ADR) reporting scheme – called the Yellow Card Scheme. This receives reports of suspected adverse drug reactions (ADRs) or side effects from healthcare professionals and patients for medicines and vaccines. The Yellow Card Scheme is the main ADR reporting scheme in the UK and was introduced in 1964 after the thalidomide tragedy highlighted the urgent need for routine monitoring of medicines. It receives about 25,000 reports of possible side effects each year. Find more information: Call the NHS direct on 0845 46 47. Call the Yellow Card freephone on 0808 100 3352.

Saúde e medicina

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

The UK YellowCard by @MHRApress

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SOURCES CDC Resources and Educational Tools - Educational Tools for Clinicians DES Lecture Presentation and DES Case Studies > http://www.cdc.gov/des/hcp/resources/tools_clinicians.html CDC Resources and Educational Tools - Educational Tools for Nurses DES Case Studies > http://www.cdc.gov/des/hcp/resources/tools_nurses.html CDC Resources and Educational Tools - Clinician Information DES References > http://www.cdc.gov/des/hcp/bibliography/index.html MORE DES DIETHYLSTILBESTROL RESOURCES DES cases and lawsuits: http://diethylstilbestrol.co.uk/studies/des-lawsuits/ DES studies on cancers and screening: https://desdaughter.com/2013/09/08/diethylstilbestrol-resources-1/ DES studies on epigenetics and transgenerational effects: https://desdaughter.com/2015/12/16/diethylstilbestrol-resources-6/ DES studies on fertility: http://diethylstilbestrol.co.uk/studies/des-and-fertility/ DES studies on gender identity and psychological health: https://desdaughter.com/2015/12/04/diethylstilbestrol-resources-3/ DES studies on in-utero exposure to DES and side-effects: https://desdaughter.com/2013/12/31/diethylstilbestrol-resources-4/ DES studies on pregnancy: http://diethylstilbestrol.co.uk/studies/des-and-pregnancy/ DES studies on the genital tract: https://desdaughter.com/2015/12/16/diethylstilbestrol-resources-7/ DES videos: https://www.youtube.com/playlist?list=PL3D4F4A11812DAE00

DES Update CDC 2003

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University of Missouri researchers have discovered that an oil and natural gas drilling technique called hydraulic fracturing uses chemicals that can disrupt the body's hormones. The researchers found that the endocrine-disrupting chemicals used in the process could interfere with a class of hormones that includes testosterone and estrogen. The findings were published in the journal Endocrinology. News = http://medicine.missouri.edu/news/0214.php Study = http://medicine.missouri.edu/news/docs/en.2013-1697.full.pdf

Fracking Chemicals Disrupt Hormone Function

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On this call, Dr. Skakkebaek presented his concerns about increasing trends in male reproductive disorders, including the significant global increase in incidence of germ cell tumors. He and colleagues from all over the world demonstrated that over half of all young men's semen quality does not meet the reference standard of the World Health Organization. Dr. Skakkebaek presented evidence linking testicular cancer, poor semen quality, childlessness, and rapidly decreasing fertility rates. He showed how there is little doubt that environmental factors, most likely associated with modern lifestyles, have - in a broad sense - had an adverse influence on male reproductive health. He and his group are examining a fundamental role that exposure to endocrine-disrupting chemicals may play in these trends, trends that in a few decades will result in decreasing populations in industrialized countries, and believes collaborative research is required to identify the causes of these adverse trends. Sources: http://healthandenvironment.org/partnership_calls/18355

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Taking place under the tagline ‘We can. I can.’, World Cancer Day 2016-2018 will explore how everyone – as a collective or as individuals – can do their part to reduce the global burden of cancer. Just as cancer affects everyone in different ways, all people have the power to take various actions to reduce the impact that cancer has on individuals, families and communities. World Cancer Day is a chance to reflect on what you can do, make a pledge and take action. Whatever you choose to do ‘We can. I can.’ make a difference to the fight against cancer. WCD2016 website http://www.worldcancerday.org/ materials http://www.worldcancerday.org/materials and ways to help http://www.worldcancerday.org/get-involved

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Created for healthcare professionals on EDCs, this slideshow by Health Care without Harm Europe (HCWH) examines the reasons why we should be concerned, who is at risk, including on pregnant women and babies, and where EDCs are hidden in the healthcare sector. Sources: https://noharm-europe.org/documents/presentation-slides-webinar-edcs-healthcare Leaflet: https://noharm-europe.org/documents/edc-leaflet-health-professionals

Endocrine disruptors in the healthcare sector

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European Commission Joint Research Center presents chemical screening methodology for the impact assessment on criteria to identify endocrine disruptors A technical meeting on the JRC methodology for evidence screening of chemicals developed in the context of the Impact Assessment on criteria to identify Endocrine Disruptors took place on 6 November 2015 in Brussels. The aim of this technical meeting was to present to Member States, Members of the European Parliament, countries from outside the EU and stakeholders the methodology developed by the JRC to estimate which chemicals may fall under the different options for criteria to identify endocrine disruptors as outlined in the roadmap. This methodology was developed in the framework of the impact assessment carried out by the European Commission on criteria to identify endocrine disruptors, in the context of the Plant Protection Products Regulation (EC) 1107/2009 and the Biocidal Products Regulation (EU) 528/2012. Sources * Methodology for EU EDC screening http://ec.europa.eu/health/endocrine_disruptors/docs/ev_20151106_co01_en.pdf * Selection of chemical substances to be screened in the context of the impact assessment on criteria to identify endocrine disruptors http://ec.europa.eu/health/endocrine_disruptors/docs/impactassessment_chemicalsubstancesselection_en.pdf

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Why was screening implemented? What is overdiagnosis? The evidence for overdiagnosis Available data Facts from recent studies Risks of screening The illusion of early detection Harms due to overdiagnosis Benefit-risk balance So, what to do? About mammograms: https://desdaughter.wordpress.com/tag/mammograms/ About overdiagnosis: https://desdaughter.wordpress.com/tag/overdiagnosis/ About screening: https://desdaughter.wordpress.com/tag/screening/

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The Presence of Gender Dysphoria, Transsexualism, and Disorders of Sexual Differentiation in MalesPrenatally Exposed to Diethylstilbestrol DES. by Scott P. Kerlin, Ph.D. MORE ABOUT DES: DES Sons studies : https://desdaughter.wordpress.com/tag/des-sons/ DES studies on cancer, breast cancer, CCAC, vaginal cancer, screening: https://desdaughter.wordpress.com/2013/09/08/des-diethylsilbestrol-resources-by-ncbi-1/ DES studies on fertility, gender identity, pregnancy : https://desdaughter.wordpress.com/2014/04/04/des-diethylsilbestrol-resources-by-ncbi-3/ DES studies on in-utero exposure to DES and DES side-effects : https://desdaughter.wordpress.com/2013/12/31/des-diethylsilbestrol-resources-by-ncbi-2/ DES articles on lawsuits and various studies. : https://desdaughter.wordpress.com/2014/10/11/des-diethylsilbestrol-resources-by-ncbi-4/ DES Videos : https://www.youtube.com/playlist?list=PL3D4F4A11812DAE00

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Une brochure permet de donner le choix aux femmes: visitez http://cancer-rose.fr/ Le dépistage organisé du cancer du sein, généralisé en France depuis 2004 et proposé aux femmes de 50 à 74 ans, fait l’objet de controverses. Celles-ci, publiées dans des revues scientifiques de premier plan, ont été longtemps minimisées auprès du grand public. Les doutes portent sur un faible bénéfice et des risques avérés. Ces derniers sont essentiellement les fausses alertes, c’est à dire l’annonce d’une lésion mammographique qui ne s’avère pas réelle, et le surdiagnostic. Le surdiagnostic est la découverte d’un cancer qui n’aurait pas affecté la santé de la femme de son vivant, s’il n’avait pas été détecté. Le bénéfice s’avère beaucoup plus faible que présenté officiellement, en raison notamment du faible risque en valeur absolue de mourir de ce cancer, et de la faible efficacité du dépistage. De ce constat est née une brochure indépendante, délivrant une information claire, qui se veut loyale, aussi complète que possible et facilement accessible. Elle est téléchargeable gratuitement directement sur la page d’accueil de "cancer rose". Seize auteurs l’ont élaborée. Destinée à la lectrice concernée par le dépistage, elle est aussi pensée comme aide au praticien démuni face aux interrogations d’une patiente. L’objectif de cette brochure, (unique en langue française alors qu’il en existe p.ex. en Allemagne pour les femmes) est de donner aux femmes le pouvoir de décider de façon rationnelle et sans être culpabilisées. Chacune se fera ainsi son opinion au travers des meilleures sources scientifiques disponibles. Même si le dépistage du cancer du sein est un programme dit de santé publique, il n’en reste pas moins que la participation est une décision individuelle qui ne peut être prise qu’en connaissance de cause, ni imposée ni subie.

Dépister le Cancer du Sein ?

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Spécialiste de la mammographie, le Dr Bernard Duperray apporte aux radiologues francophones un enseignement indépendant des politiques de santé à la mode. Les observations cliniques et les résultats scientifiques présentés apportent la preuve des contradictions entre la représentation classique du cancer du sein et l’histoire naturelle des maladies cancéreuses du sein, hétérogène et imprévisible. Consultez et téléchargez ci dessous le fichier de 76 diapositives passionnantes de la conférence de Bernard DUPERRAY et vous n’aurez plus de doutes sur la réalité du surdiagnostic dans le dépistage organisé du cancer du sein. Sources: http://www.formindep.org/Cours-de-senologie-de-Bernard.html

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Sommaire: 1/ Qu’est ce qu’un pesticide ? 2/ Répartition de la consommation de pesticides en France 3/ Grenelle 2 et plan ecophyto 4/ Comment réduire l’utilisation des pesticides en milieu agricole ? 5/ Production Intégrée, une autre forme d’agriculture 6/ Agriculture biologique 7/ Comment remplacer les pesticides en agriculture ? 8/ Zéro pesticide dans les collectivités 9/ Désherber sans chimie en zone urbaine 10/ Jardinage et usage domestiques 11/ Jardiner sans pesticides, comment faire ? Téléchargez le nouvel appel à participation et diffusez le plus largement possible… http://www.semaine-sans-pesticides.fr/wp-content/uploads/2014/09/Appel-%C3%A0-participation_SPAP_2015_FR.pdf Visitez le site http://www.semaine-sans-pesticides.fr/ Nos posts tagués pesticides https://desdaughter.wordpress.com/tag/pesticides/

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Les alternatives aux pesticides

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Omniprésents dans notre environnement, les pesticides polluent l'air, les sols et les eaux souterraines ou de surface, mettant en danger de nombreuses espèces animales indispensables à notre survie. Téléchargez le nouvel appel à participation et diffusez le plus largement possible… http://www.semaine-sans-pesticides.fr/wp-content/uploads/2014/09/Appel-%C3%A0-participation_SPAP_2015_FR.pdf Visitez le site http://www.semaine-sans-pesticides.fr/ Nos posts tagués pesticides https://desdaughter.wordpress.com/tag/pesticides/

L'impact des pesticides sur la santé

L'impact des pesticides sur la santé

L'impact des pesticides sur la santé

La Semaine pour les alternatives aux pesticides est un événement national et international annuel du 20 au 30 mars pour informer sur l’impact des pesticides sur l’environnement et la santé. Durant la Semaine tout le monde est invité à organiser des évènements: particuliers, associations, agriculteurs, collectivités locales, entreprises, écoles… Pas besoin de gros moyens ou de beaucoup d’expérience. Avec un peu d’imagination, de volonté et d’organisation, il est facile de créer une action. Cet évènement est devenu le rendez-vous incontournable pour celles et ceux qui souhaitent construire un avenir sans pesticides. Cette initiative de l’association Générations Futures et de l’ACAP, collectif de 170 organisations, a été lancée en 2006 et depuis chaque édition connaît un succès croissant. Téléchargez le nouvel appel à participation et diffusez le plus largement possible… http://www.semaine-sans-pesticides.fr/wp-content/uploads/2014/09/Appel-%C3%A0-participation_SPAP_2015_FR.pdf Visitez le site http://www.semaine-sans-pesticides.fr/ Nos posts tagués pesticides https://desdaughter.wordpress.com/tag/pesticides/

La semaine pour les alternatives aux pesticides

La semaine pour les alternatives aux pesticides

La semaine pour les alternatives aux pesticides

Cervical Cancer and HPV by CANSA

Cervical Cancer and HPV by CANSA

Cervical Cancer and HPV by CANSA

by the Collaborative on Health and the Environment Prenatal Exposure to EDCs and Obesity: Combining Toxicology and Epidemiology with Dr. Juliette Legler The incidence of childhood obesity has reached epidemic proportions globally and there is an urgent need to better understand the impact of early life exposure to chemical obesogens on the development of obesity. The European OBELIX (Obesogenic endocrine disrupting chemicals: linking prenatal exposure to the development of obesity later in life) project examined the hypothesis that prenatal exposure to endocrine disrupting compounds (EDCs) plays a role in the development of obesity later in life using a multidisciplinary approach that combined various approaches, including epidemiology and toxicology. The project focused on assessing prenatal exposure to major classes of EDCs including dioxins and dioxin-like polychlorinated biphenyls, non-dioxin-like PCBs, brominated flame retardants, organochlorine pesticides, phthalates, and perfluorinated alkyl acids. Toxicological studies in OBELIX demonstrated that perinatal dietary exposure to representatives of these EDC classes resulted in metabolic changes that persisted into adulthood, long after termination of exposure at weaning, and that effects were compound- and sex-specific. The observed effects were not consistently towards an obese phenotype; a lean phenotype was also observed in animal studies for some compounds. Epidemiological studies in birth cohorts throughout Europe indicated associations between pre- and postnatal exposure to EDCs and early growth trajectories and body mass index in children up to 7 years. This call reviewed the main findings of the largest project up to now to examine the obesogen hypothesis. Sources: http://www.healthandenvironment.org/partnership_calls/14860

Prenatal Exposure to EDCs and Obesity

Prenatal Exposure to EDCs and Obesity

Prenatal Exposure to EDCs and Obesity

by the Collaborative on Health and the Environment On this call Retha Newbold, MS, Researcher Emeritus, National Toxicology Program, National Institute of Environmental Health Sciences, discussed the program called “The Consortium Linking Academic and Regulatory Insights on the Toxicity of Bisphenol A (CLARITY-BPA)” which is an interagency agreement, conducted under the auspices of the National Toxicology Program (NTP), between The National Institute of Environmental Health Sciences (NIEHS) supported grantees, the staff of the Division of the National Toxicology Program (DNTP) at NIH/NIEHS, and the Food and Drug Administration at the National Center for Toxicological Research (FDA/NCTR). The goals of the consortium are to enhance the utility of a perinatal 2-year GLP chronic toxicity study on BPA for regulatory decision-making by incorporating a wide range of doses and some additional disease-related endpoints that are not usually covered. To this end, 12 NIEHS grantees are studying hypothesis-driven mechanisms by investigating specific endpoints that maybe altered by BPA including behavioral/neuroendocrine, immune function, cardiac, reproductive tract, cancer, thyroid, and other organ systems. This consortium is unique in that it combines the knowledge and skills of the NTP staff with experts from the academic field who are covering more mechanistic studies. Although this program focuses on BPA, it may provide an example of how to better study effects of other endocrine disrupting chemicals especially since numerous organ systems may be involved. Sources: http://www.healthandenvironment.org/partnership_calls/14639

CLARITY BPA: a Novel Approach to study EDCs

CLARITY BPA: a Novel Approach to study EDCs

CLARITY BPA: a Novel Approach to study EDCs

Held every 18 November, European Antibiotic Awareness Day (EAAD) is a day to encourage responsible use of antibiotics. The plan for EAAD 2014 is to increase measurable engagement by healthcare professionals and the public. Our main objective is that by 30th November we have a combined 10, 000 Antibiotic Guardian pledges from healthcare professionals and the public to at least one pledge for prudent use of antimicrobials. Sources: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/369778/EAAD-AG_Campaign_Resources_Toolkit_2014.pdf Posters and Leaflets: https://www.gov.uk/government/publications/european-antibiotic-awareness-day-and-antibiotic-guardian-posters-and-leaflets Video: http://youtu.be/7PhmyNBWGik?list=PL5iZsTMBd0hjSm71Z8WOYn3_CdPC09WCX Website: http://antibioticguardian.com/

EAAD 2014 Resources Toolkit for Healthcare Professionals in England

EAAD 2014 Resources Toolkit for Healthcare Professionals in England

EAAD 2014 Resources Toolkit for Healthcare Professionals in England

How the Next Generation's Brain Functions are Endangered by EDCs and Other Environmental Chemicals by the Collaborative on Health and the Environment Dr. Philippe Grandjean suggests that new scientific insights reveal that the next generation's brain functions are endangered by environmental chemicals. The fetus is not protected by the placenta and therefore shares the mother's cumulated exposures to toxic chemicals. Infants and children are likewise exposed to a cocktail of foreign substances against which the body has no innate defense. Prenatal and early postnatal brain development is an extremely complex process that we now know is uniquely vulnerable. Lead, mercury and a few other substances have long been known to be toxic to brain development. Recent research suggests that many chemicals, perhaps thousands, may cause similar effects because they can gain access to the developing brain and exert their toxicity to brain cells. This new insight needs to be translated into public policy to protect the brain functions of the next generation. On this call Dr. Grandjean discussed what he terms "chemical brain drain" and how we might work to protect the brain health of future generations. Sources: http://www.healthandenvironment.org/partnership_calls/14316?res

Dr. Philippe Grandjean on Chemical Brain Drain

Dr. Philippe Grandjean on Chemical Brain Drain

Dr. Philippe Grandjean on Chemical Brain Drain

by the Collaborative on Health and the Environment The call featured Dr. Frederica Perera who reviewed data from a longitudinal cohort study following mothers and children from pregnancy into adolescence. In this study, prenatal exposure to the combustion related air pollutants, polycyclic aromatic hydrocarbons, is associated with adverse neurodevelopmental outcomes as well as other disease endpoints. Prevention strategies were also discussed. Sources: http://www.healthandenvironment.org/partnership_calls/14035

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These are simplified slides discussing the regulation of cardiac output and venous return. Learning objectives: 1. Comprehend the determinants of cardiac output and factors affecting cardiac output 2. Comprehend the factors affecting stroke volume and heart rate and total peripheral resistance 3. Identify the factors regulating venous return 4. Discuss the causes of high and low output cardiac failure 5. Enlist the functions of veins and recognise the significance of venous reservoirs Study Resources: 1. Chapter 20, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 30 and 32, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 10, Human Physiology by Lauralee Sherwood, 9th edition 4. Physiology, Cardiac Output - StatPearls https://www.ncbi.nlm.nih.gov/books/NBK470455/

Cardiac Output, Venous Return, and Their Regulation

Cardiac Output, Venous Return, and Their Regulation

Cardiac Output, Venous Return, and Their Regulation

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