O slideshow foi denunciado.
Utilizamos seu perfil e dados de atividades no LinkedIn para personalizar e exibir anúncios mais relevantes. Altere suas preferências de anúncios quando desejar.

RNAi and microRNA-mediated gene regulation

313 visualizações

Publicada em

An animated explanation of RNA interference (RNAi) and microRNA-mediated gene regulation.

Publicada em: Ciências
  • Entre para ver os comentários

  • Seja a primeira pessoa a gostar disto

RNAi and microRNA-mediated gene regulation

  1. 1. GENE RNA PROTEINm sRNA RNA interference transcription translation miRNA carried by Argonaute (Ago) siRNA DNA micro-RNA small interfering RNA messenger small RNA amino acids outside (exogenous) sources RNA translational inhibition mRNA degradation RNAi not all genes make protein target binding
  2. 2. miRNA/siRNA biogenesis Dicer Microprocessor Nucleus Cytoplasm Argonaute pre-RISC (RNA-induced silencing complex) mature RISC (core) pri-miRNApre-miRNA RNA duplex exogenous dsRNA (siRNA precursors)
  3. 3. Ago effector pathway target binding perfect complementarity (siRNA) & slicing Ago partial complementarity (miRNA) target repression mRNA degradation mRNA degradation translational inhibition sequestration decapping complex deadenylation complex target cleavage exonuclease chewing cofactor recruitment Ago GW182

×