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CRISPR Presentation

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CRISPR Presentation

  1. 1. CRISPR A New Gene-Editing Tool With Significant Promise and Room for Regulation Brian A. Smith, Science Policy InternOct. 27, 2015
  2. 2. 4 Questions • What is CRISPR? • Who’s interested in CRISPR? • Why should R!A care? • What can R!A do?
  3. 3. What is CRISPR? • Clustered • Regularly • Interspaced • Short • Palindromic • Repeats 1. Virus attacks bacteria cell, injecting its DNA to wreak havoc and spread 2. Bacteria counters this with CRISPR/Cas9 immune system response • CRISPR/Cas9 is a nuclease (cuts DNA) with guide RNAs 3. CRISPRs can match with viral DNA sequences 4. Cas9 can literally cut at those specific sequences 5. Once cut, viral DNA is no longer a threat 6. CRISPR/Cas9 can do this with any DNA, not just viral DNA (more on this later!) 7. This advance has led to a gene-editing revolution
  4. 4. What is CRISPR?
  5. 5. Who’s interested in CRISPR? GOOD  Basic Scientists • Make transgenic animal models  Agricultural Scientists • Make food to withstand disease  Medical Scientists • Cure/prevent genetic diseases 2012 Today
  6. 6. Who’s interested in CRISPR? BAD χ Military • “Want to militarize it” χ Rich People • “Want to make drone workforce” χ Mad Scientists • “Has science gone too far?!” χ China • Already used CRISPR in human embryo
  7. 7. Why should R!A care? • This is going to be one of the biggest scientific issues in the next decade • NAS Human Gene-Editing Initiative • Rep. Bill Foster (D-IL-11) • CRISPR/Cas9 has started a worldwide conversation on gene-editing
  8. 8. What can R!A do? • We need to determine where we stand • We should talk with researchers using CRISPR/Cas9 • We should work alongside NAS and other science and medicine governing bodies to convey their insights to policymakers and the general public • We can highlight the medical benefits of this technology
  9. 9. Questions?