4. Cause of peptic Ulcer:
Destruction of the intestinal
mucosal lining of the stomach
by hydrochloric acid.
Infection with a bacterium called
Helicobacter pylori,
Or by long-term use of aspirin or
other Non-Steroidal Anti-
Inflammatory Drugs (NSAIDs),
such as Ibuprofen
5. • Therapeutic aims:
(a) to relieve pain;
(b) to accelerate healing; and
(c) to prevent ulcer recurrence.
• Therapeutic approaches are threefold :
(I) to reduce aggressive forces by lowering H+ output,
(II) to increase protective forces by means of
mucoprotectants; and
(III) to eradicate Helicobacter pylori.
6. Basic types of Anti-ulcer drugs:
I. Lowering of Acid
Concentration
Agents for acid neutralization
Inhibitors of acid production
II. Protective Drugs
III. Eradication of
Helicobacter pylori
10. Misoprostol
a semisynthetic prostaglandin derivative with greater
stability than natural prostaglandin
Locally released prostaglandins (PGF2α, PGE2) promote mucus
production in superficial cells
and inhibit acid secretion ofparietal cells
11. III. Eradication of Helicobacter pylori
Plays an important role in the pathogenesis of chronic
gastritis and peptic ulcer disease.
The combination of antibacterial drugs and omeprazole
has proved effective.
12. References:
“Color Atlas of Pharmacology” by Heinz Lüllmann, Lutz
Hein, Klaus Mohr and Detlef Bieger.
Goodman & Gilman’s “Manual of Pharmacology &
Therapeutics”.
“Essentials of Medical Pharmacology” by KD TRIPATHI.
“A Textbook of Clinical Pharmacology and Therapeutics”
by JAMES M RITTER, LIONEL D LEWIS and TIMOTHY GK
MANT.
Internet Sources.
