A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. crude drug used is Ergot ergot life cycle 1. over wintering stage 2. sexual reproduction 3. asexual reproduction

1. OXYTOCIC
Presented by- Archana Chavhan
KYDSCT's Sakegaon College of
Pharmacy, Bhusawal

2. Oxytocic
•Oxytocic agents are
that stimulate
uterine contraction
and are used to
induce labor.

3. Ergot
Synonyms: Ergot; Rye Ergot;
Biological Source: Ergot is the dried
sclerotium of a fungus, Claviceps
purpurea Tulasne, belonging to family
Clavicipitaceae,
Chemical constituents:

4. •Ergot life cycle
The life cycle of the ergot
consists of following
stages,
1. Over wintering stage
2. sexual stage
3. Asexual stage

6. 1. Overwintering
stage
• The sclerotia are produced in late
summer. these sclerotia germinate in the
spring to produce purple coloured stalks
which on further growth form flattened
spherical cavities known as perithecia.
• Each perithecium contain several asci.
Each ascus contains eight threads like
ascopores.
• Ascopores come out & get dispersed by air
& become entagled with the stigma of host
& produce mycelia which penetrate
through ovary.

7. 2. sexual
stage
• The mycelia give rise to conidia,
produced from the surface of ovary.
Honey –dew attracts insects, along with
it conidia are carried from one place
to another by insects & is known as
honey –dew stage.
• Hyphae penetrate deeply into the ovary
& develop into mass covering entire
ovary which results in formation of
elongated sclerotium

8. 3. Asexual
stage
• If Ergot is not collected, it falls on
the ground.
• In the next spring session they
produce stalked projections known
as stromata which have globular
heads.
• In the inner surface of the heads
there are many flask-shaped pockets
known as perithecia. Each of these
perithecia contains many sacs (asci)
which possesses eight of the thread-
like ascospores.
• These ascospores are carried out by
insects or wind to the flowers of the
rye as described in the first stage.

9. Therapeutic uses
Ergotamine is used in
treatment of migraine
Used as oxytocic to
stimulate the uterine
contraction which
assists delivery in
labor
It reduces post-
partum haemorrhage