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Hyperglycemia leads to microvascular complications and
glucotoxicity, which results in metabolic abnormalities and
progression of the disease. Inspite of many drugs available,
managing hyperglycemia remains a challenge. We are still far from a molecule that will not cause hypoglycemia and weight gain and at the same time offer durable and optimum glycemic control. Inhibitors of renal sodiumeglucose cotransporter have recently been developed and this acts independent of beta cell and insulin resistance. This also causes weight loss and improves glycemic control without causing hypoglycemia.