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If you’re taking cholesterol medicine, your doctor may request a Cholesterol Medication Maintenance Panel before a refill is prescribed. It’s also perfect for people who need to have their cholesterol and liver functions tested on a routine basis or for those simply interested in knowing their cholesterol level.
Cholesterol is the major sterol in the animal tissues.
Cholesterol is present in tissues and in plasma either
as free cholesterol or as a storage form, combined
with a longchain fatty acid as cholesterol ester.
In plasma, both forms are transported in protein
Plasma lowdensity lipo protein (LDL) is the vehicle
of uptake of cholesterol and cholesterol ester into
Free cholesterol is removed from tissues by plasma
highdensity lipo protein (HDL) and transported to the
liver, where it is eliminated from the body either
unchanged or after conversion to bile acids in the
process known as reverse cholesterol transport.
VAP (Vertical Auto Profile)
The VAP Test uses the most advanced technology that
provides the most accurate picture of an individual’s
potential for heart disease and diabetes. This information is a
great tool for your physician to provide the proper steps in
preventing future heart attacks. The VAP Test provides a
detailed report of individual lipoprotein subclasses and
Apolipoprotein subclasses. This test not only includes the basic
cholesterol tests, but also identifies any cholesterol
abnormalities that can be a precursor to heart
Disease or diabetes. This is not a fasting blood test; this gives
you flexibility on different appointment times, not just
early in the day.
STRUCTURE OF CHOLESTEROL
The structure of cholesterol consists of four fused
rings (The rings in steroids are denoted by the
letters A, B, C, and D.), with the carbons numbered
in the sequence, and an eight numbered, and
branched hydrocarbon chain attached to the D ring.
Cholesterol contains two angular methyl groups: the
C19 methyl group is attached to C10, and the C18
methyl group is attached to C13.
The C18 and C19 methyl groups of cholesterol lie
above the plane containing the four rings.
STRUCTURE OF CHOLESTEROL
Steroids with 8 to 10 carbon atoms in the side chain
and an alcohol hydroxyl group at C3 are classified as
sterols. Much of the plasma cholesterol is in the
esterified form (with a fatty acid attached at carbon
3), which makes the structure even more
FUNCTIONS OF CHOLESTEROL
Cholesterol is the most abundant sterol in humans and
performs a number of essential functions. For example
It is a major constituent of the plasma membrane and of
It is a precursor of bile salts,
It is a precursor of steroid hormones that include adreno
cortical hormones, sex hormones, placental hormones etc
Also a precursor of vitamin D, cardiac glycosides,
Sitosterol of the plant kingdom, and some alkaloids.
It is required for the nerve transmission. Cholesterol is
widely distributed in all cells of the body but particularly
abundant in nervous tissue.
SOURCES OF CHOLESTEROL
Cholesterol is derived from
synthesis and from the hydrolysis of cholesterol
A little more than half the cholesterol of the body
arises by synthesis (about 700 mg/d), and the
remainder is provided by the average diet.
The liver and intestine account for approximately
10% each of total synthesis in humans.
Virtually all tissues containing nucleated cells are
capable of cholesterol synthesis, which occurs in the
endo plasmic reticulum and the cytolysis
VARIATION OF SERUM
The normal serum cholesterol concentration ranges
between 150 220 mg/dl
High cholesterol concentration is found in
Familial hyper cholesterolemia
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