1.
For every 100
articles
published on
gluten
intolerance…
There are 14
books
discussing
the solution
& 96 the
implications!
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The gluten hype

2.
Gluten related conditions
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Gluten Sensitivity
Celiac Disease Non-Celiac Gluten Sensitivity Wheat Allergy
Gluten Ataxia Dermatitis Herpetiformis

3.
timeline
1 AD
Aretaeus from
Cappadocia
describes CD
(Celiac Disease) as
a disease in the
abdomen.
1st systematic
review at Uni of
Birmingham
identifying
diagnostic criteria.
1966 1995
Dr Marsh
demonstrates that
reaction to gluten
may not manifest
any gastrointestinal
abnormalities.
2009
Rubio-Tapia A
shows a 400% ↑ in
the occurrence of
CD over the last 50
years.
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Gluten Intolerance throughout time

4.
levelsofgluten
12-14% in bread
7-11% in pastries
levelsofglutenins
more chewy
less chewy
howrefinedthegrainis
Wheat
Rye
Barley
Grains containing
the gluten protein
Proteins in gluten
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The biochemistry of gluten
Glutenins *
Gliadins
α-gliadins
ω-gliadins
γ-gliadins
deaminated
gliadins
Gluten
*In Barley and Rye it is called hordein and secalin respectively.

5.
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Gluten’s disruptive mechanism in Celiac Disease
Gluten
Gliadin
Glutenins
Proline
Glutamine
when
partially
digested
cross the
intestinal
lining
Intestinal lumen Blood circulation
tissue transglutaminase
(anti-tTG)
Deaminated gliadin
peptides (DGP)
DGP-tTG complex
+
antibodies

6.
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How herbicide glyphosate can
contribute to Celiac Disease Glyphosate
↑ of Zonulin
breakdown of
tight junctions
leaky gut /
intestinal
damage
↓ Lactobacillus &
Bifidobacterium
↓ capacity to
synthesise folate
folate deficiency
impaired bile
production in
gallbladder
fatty liver
disruption of vit A
metabolism in the
liver
↑ of retinoic acid
teratogenic effects
glyphosate disrupt
sulphate transport
from gut to liver
causation
association
Celiac Disease

7.
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Celiac Disease diagnosis algorithm The part of the small
intestine the biopsy is
done.
Normal or
minimal abnormal
IELs < 25
IEL: Intraepithelial Lymphocytes
IELs > 25
latent CD
Unexplained neurological
or psychiatric disorders
(ie autism, schizophrenia)
gastrointestinal
inflammation
(ie H pylori)
Significant villous
atrophy
CD
IELs < 25IELs > 25
silent CDCD

8.
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Gluten Challenge Test
1. Eliminate from your kitchen
any gluten containing foods
2. Try alternatives to the gluten
containing products you
usually consume.
3. Put aside any cosmetics and
hygiene products containing
gluten.
1 week 4-6 weeks
Follow a Gluten Free Diet
Wheat
Barley
Rye
Spelt
Kamut
Couscous
Semolina
Triticale
Hidden sources
Rice
Sorghum
Millet
Buckwheat
Quinoa
Amaranth
Teff
Tapioca
Bean flours
Challenge Day
1. Measure your Heart Rate
(HR)
2. Have a plate of
pasta
3. Measure your HR 10, 30 & 60
mins after eating.
If your HR increases by 10 points
during any of the intervals or you
notice any adverse symptoms in
the next 24 hours you are GS.
Gluten ChallengePreparation phase

9.
4 steps in order to reduce the chances of a child to develop CD
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timeline
Avoid a
cesarean
delivery
Introduce
gluten while
breastfeeding
Introduce
gluten between
4 and 7 months
Avoid a high
gluten
consumption
for the first 2
years

10.
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