Selected Summit Sponsors and Partners showcase their most promising brain health & enhancement initiatives and solutions.
8.30-10am. At the frontier with Neuroscape, VR/ AR and Photobiomodulation
*Adam Gazzaley, UCSF Professor of Neurology, presents Neuroscape
*Dr. Walter Greenleaf, Medical VR/ AR Expert at Stanford Virtual Human Interaction Lab, provides an overview of health applications of virtual & augmented reality (VR/AR)
*Dr. Lew Lim, Founder & CEO of Vielight, discusses photobiomodulation as a new way to enhance brain function
contact information.
10.30-11am. Dr. Bob Schafer, Director of Research at Lumos Labs, presents their expanding vision for brain training, including mindfulness.
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
3. Dr. Adam
Gazzaley, UCSF Professor of
Neurology, will
present Neuroscape
Dr. Lew Lim, Founder & CEO
of Vielight, will
discuss photobiomodulation as
a new way to enhance brain
function.
Dr. Walter Greenleaf,
Medical VR/ AR Expert
at Stanford Virtual Human
Interaction Lab, will provide
an overview of health
applications of virtual &
augmented reality (VR/AR).
Dr. Bob Schafer, Director of
Research at Lumos Labs, will
present their expanding vision
for brain training,
including mindfulness.
4. Adam Gazzaley, MD PhD
Founder & Executive Director | Neuroscape
Professor | Neurology, Physiology and Psychiatry
University of California, San Francisco
Co-Founder
Akili Interactive Labs, Sensync & Jazz Venture Partners
Bridging the Gap Between Technology and Neuroscience
6. TECHNOLOGY NEUROSCIENCE CLINICAL EDUCATION
Roger Angera
Director
Interactive Media
Director
Multimodal Biosensing
David Ziegler
Director
Theodore Zanto
Director
Joaquin Anguera
Director
Melina Uncapher
14. 2017
Clinical Program
▸ Attention Deficit Disorder
▸ Depression
▸ Autism
▸ Sensory Processing Disorder
▸ Mild Cognitive Impairment
▸ Traumatic Brain Injury / PTSD
▸ Multiple Sclerosis
▸ Dyslexia
▸ Cancer-Related Cognitive Impairment
▸ Delirium
Active studies in
Neuroscape
Active studies in
collaborate
New studies in
Collaboration
15. 2017
Education Program
• Developed mobile assessments of cognitive control for kids
• Developed mobile assessments of math/reading for kids
• Used these mobile apps to study one of largest populations of in-
school students (N=1,254): 2-yr longitudinal study
• Leveraging population to also study how technology use impacts
cognition and academics.
2018
• Assess how training improves core cognitive capacity
• Assess how training improves academic achievement
• Translate these findings into evidence-based education
17. • NeuroTech - CHUV [Lausanne, Switzerland]
• COBTEK IA - University Cote d’Azur [Nice, France]
• Benioff Children’s Hospital - UCSF [San Francisco, California]
• Osher Center for Integrative Medicine - UCSF [San Francisco,
California]
• Social Brain in Action Laboratory - Bangor University [Bangor, United
Kingdom]
• Educational Neuroimaging Center - Technion [Haifa, Israel]
Members Benefits
• Participate in fellowship exchange programs
• Establish Neuroscape Research Labs (NRLs)
• Share software/ games
• Leverage access to new technologies
• Access new funding opportunities
• Share best practices for study design
• Perform multi-site clinical trials
18. Alzheimer’s Disease
Anxiety Disorder
Attention Deficit Disorder
Depression
Post Traumatic Stress Disorder
Autism
Schizophrenia
Traumatic Brain Injury
Parkinson’s Disease
Multiple Sclerosis
Over the Next 10 Years ...
Education
Wellness
Addiction
20. • Adam Gazzaley
• Ted Zanto
• Joaquin Anguera
• Peter Wais
• Melina Uncapher
• David Ziegler
• Roger Anguera
• Lara Stables
•Jo Gazzaley
• WanYu Hsu
• Courtney Gallen
• Gang Li
• Ilse Pastor
• Yan Wang
• Jaqueline Ayyoub
Core Team
• Sierra Niblett
•AJ Simon
• Meike Gugel
•Josh Volponi
• Juliana Souza
• Jordin Rodondi
• Vinith Johnson
• Richard Campusano
• Alan Duanmu
• Zoe D’Esposito
• Lauren Dacorro
• Olivia Montgomery
• Buddy Lorentz
• Jessica Schactner
• Jesica Youngerneuroscape.ucsf.edu
21. Financial Support
• National Institute on Aging
• National Institute of Mental Health
• National Science Foundation
• American Federation of Aging Research
• Robert Wood Johnson Foundation
• Zynga.org
• Center 17
• Sandler Foundation
• Tim Ferriss
• Magdalena Yesil
• Feldman Family Foundation
• Grammy Foundation
• Biggelsworth Foundation
• Laney and Pasha Thornton
• Mickey and Caryl Hart
• Pasha and Laney Thornton
• Getty Family
• Ellison Medical Foundation
• Pfizer / Eisai
Industry Partners
• Neuroelectrics
• Akili
• Empatica
• Zynga
• High Fidelity
• Brain Vision
• Apple
• Sony
• NVIDIA
• Meta
• Cognionics
• Qusp
• Sara and Ev Williams
• Elise and Tully Friedman
• Dolby Family
• Roberta and Jamie Gates
• Jeff Stone
Network
• Lounsbery Foundation
• Kavli Foundation
• Posit Science
30. Digital Health Platforms deliver interventions to patients, and
parse data for enhanced analysis and improved protocols
Dashboards
Physician
Payor
Admin
Wearable
sensors
Mobile
Backend
User auth
Device mgmt
App provisioning
Restful API
Access codes
Messaging
Mail service
Batch/scheduling
Push notification
Analytics
Engagement
RT analytics
Content store
Data tracking
Metrics
Storage Transactional
store
Real time
event store
Data
warehouse
Data store
Infrastructure Log
aggregation
Monitoring
Deployment
agents
SDK
Patient Facing
Applications
Assessments
Reminders
Badges
Interventions
Graphics
data
direction
data
access/analysis
31. Although entertainment,
social connection and gaming
will drive the initial adoption of
VR technology, the deepest
and most significant market
for VR will be in clinical care
and in improving health and
wellness.
Medical Applications of Virtual Reality Technology
32. • Current technologies and concepts are founded on more than 30 years of research and development
• Recent changes in cost and access make VR affordable
• VR tech is currently used for prevention, evaluation, treatment and chronic disease management
• After years of validation and use by early adopters - VR technology is poised to move to the
mainstream
• On the horizon: enhanced, ubiquitous, informative and integrated
Virtual Reality Technology For Medicine
33. • Prevention and Wellness
• Objective Assessments
• Improved Interventions
• Facilitate Adherence
• Distributed Care Delivery
VR and AR technology will significantly impact Medical Care
37. Academic research has indicated that Virtual Reality can effectively treat
a wide variety of clinical problems – ranging from addictions, to stroke,
to PTSD
40. Now is the time for VR
VR technology is now affordable, scalable
and accessible to the marketplace. The
VR category is attracting interest and
investments from major players.
Facebook - Oculus
Samsung - GearVR Sony – PlayStation VR
Microsoft - HoloLens
HTC - Vive OSVR
44. 11.3
16.9
27.3
41.5
56.2
68.0
Year 2 Year 3 Year 4 Year 5 Year 6Year 1
Initial adoption will be driven through
game console, PC gaming and mobile
phone bundling.
Within 3 years, VR will likely be adopted
by 30 million users.
*Based on agent based modeling by
Lieberman Research Worldwide
Within 6 years, VR will likely be adopted by 70 million users
46. Phobias / PTSD
Stress Management /
Relaxation
Surgical Training /
Planning
Physical
Rehabilitation
Pain Management
Exercise
Cognitive
Rehabilitation
Optical
Rehabilitation
Addictions
Neuropsychological
Assessments
Cognitive Training
Wellness
Sports Training Disability Solutions Speech Therapy
Autism Spectrum
Disorder
Mood Disorders ADHD Senior Care
72 Emerging Medical VR Companies
18 Clinical Sectors
47. Over 30 years of academic
research and over 3000 studies
demonstrate that VR can
improve behaviors,
attitudes, and health
Until now, the technology was
expensive, bulky, and difficult to use.
Today, we have the advancements to
bring VR to scale in healthcare.
Why Now?
48. • Medical Interventions
• Clinical Assessments
• Medical Training
• Health & Wellness
MEDICAL APPLICATIONS OF VR
49. • Clinical Skill Training
• Surgical Skill Training
• Interpersonal Skill Training
• Use of Equipment and Tools
• Team Training - eg: Emergency
Department, Surgical Team
• Emergency Response Training
and Rehearsal
• Empathy
Medical Training
50. • Medical Image Review
• Neuropsychological
Assessments
• Activities of Daily Living
Assessments
• Physical Medicine – OT / PT
• Behavioral Medicine –
psychology, psychiatry
DIAGNOSTIC ASSESSMENTS
51. Standardized Environments for Neurocognitive Evaluation
New Approaches for Cognitive Assessment
Migrates traditional paper
and subjective evaluations
to a more sophisticated
level.
Provides robust
assessments that can
challenge cognitive skills in
a more natural,
standardized, objective
and reproducible manner.
52. • Neuro-Rehabilitation - Stroke and Traumatic Brain Injury
• Physical and Occupational Therapy
• Speech- Language Therapy
• Optical Rehabilitation –
Strabismus, Amblyopia
• Acute and Chronic Pain
• Weight Management
Virtual environments are currently used clinically
to treat several important clinical problems
Here are a few examples -
53. • Drug and alcohol abuse
• Schizophrenia
• Post-traumatic stress disorder (PTSD)
• Generalized Anxiety Disorder
• Mood Disorders - Depression
• Mild Cognitive Impairment
• Autism Spectrum Disorder
• ADHD
Virtual environments are used clinically to treat several
important mental and behavioral health problems
54. • Phobia and anxiety disorders
• Obsessive Compulsive Disorder (OCD)
• Developmental disabilities
• Conduct disorders
• Anger management
• Eating disorders
• Impulsive disorders
• Learning disabilities
• Neuro-cognitive disorders
Virtual environments are used clinically to treat several
important mental and behavioral health problems
55. • Weight Management
• Cognitive Function Training –
Sequencing, Situational Awareness,
Decision Making
• Exercise
HEALTH AND WELLNESS
• Stress Management
• Disability Solutions
• Addressing Isolation
• Grief Counseling
• Mood and Resilience
60. PTSD, Phobias, and Anxiety Disorders
• Exposure-based treatments can be conducted in the safety and comfort of an office
setting
• Effective tools for treating a variety of clinical problems, in particular anxiety and addictive
disorders
• Fully immersive environments, with include the use of a head mounted display, 3D sound,
tactile stimulation via shaking platform, and olfactory stimulus are used for PTSD therapy
64. VR for Pain Distraction
Clinical Research and Validation
Interactive virtual environments significantly
reduce pain from as much as 44% during
the most painful procedures
(ex: burn wound treatment)
Diverts patient attention away from perceiving
and feeling pain; (selective attention theory)
Decreases pain-related brain-activity
Reduces need for anesthesia, opioid medication
No pharmacological side effects
67. Ability to change attitudes and behavior after “being” one’s future self.
Leveraging Mirror Neurons
68. Improved Assessments and Diagnostics
Addressing Isolation and Loneliness
Acute and Chronic Pain
Depression and Anxiety Disorders
Physical and NeuroRehabilitation
Design for Disabilities
Post-Discharge Follow-up
Staff Training: not just procedures, but
empathy
Virtual Environments and Senior Care
69. • Current technologies and concepts are founded on more than 30 years of research and development
• Recent changes in cost and access make VR affordable
• VR tech is currently used for prevention, evaluation, treatment and chronic disease management
• After years of validation and use by early adopters - VR technology is poised to move to the
mainstream
• On the horizon: enhanced, ubiquitous, informative and integrated
Virtual Reality Technology For Medicine
71. Photobiomodulation:
A new way to enhance brain function
By:
Lew Lim, PhD, DNM, MBA
Founder & CEO
Vielight Inc.
SharpBrains Summit 2017
December 5-7, 2017
75. Molecular and Cellular Mechanisms of PBM
75
Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016 Oct 1;6:113-124. eCollection 2016.
Red and Near-
infrared (NIR) Light
76. Tissue Modulation in Photobiomodulation
76
Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016 Oct 1;6:113-124. eCollection 2016.
Summary re: Brain Health:
• Restores/repairs
• Maintains
• Enhances
77. treated many medical brain conditions
In Human studies:
• Stroke
• Traumatic brain injury
• Alzheimer’s disease /
dementia
• Coma
• Depression and anxiety
In Animal studies:
• Parkinson’s disease
• Multiple sclerosis
In peer-reviewed literature, PBM has
78. Red/NIR Light Mitigates Alzheimer’s in Lab
Animals
Purushothuman S, et al (2014). Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models Alzheimer's Research &
Therapy. 6:2
Sources:
Taboada LD, et al (2011). Transcranial Laser Therapy Attenuates Amyloid- Peptide Neuropathology in Amyloid- Protein Precursor Transgenic Mice. Jnl. Alz. Dis. 521-535.
79. Theories and Evidence support a Wearable
Photobiomodulation Device for Alzheimer’s
Saltmarche AE, et al. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal
Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017 Aug 1; 35(8): 432–441
80. The Default Mode Network is targeted
Comprehensive response is achieved while maintaining wearability
82. Light
Processor: Visual Cortex
Picture: Discovery Eye Foundation. The Optic Nerve and its Visual Link to the Brain
Pulsing Light at 40 Hz (Gamma) Reduces β-amyloid
Load in the Visual Cortex
Based on: Iaccarino HF, Singer AC, Martorell AJ, et al (2016). Gamma frequency
entrainment attenuates amyloid load and modifies microglia. Nature 540(7632): 230-
235.
93. Transcranial PBM Improves Reaction Time
Grover F, Weston J, Weston M. Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures. 2016. Photomed Las
Surg.
94. DMS: Delayed Match-to-sample
Gonzalez-Lima F, Barrett DW. Augmentation of cognitive brain functions with transcranial lasers. 2014. Frontiers Sys Neurosc.
8(36)
Transcranial PBM Improves Speed and
Accuracy of Memory Retrieval
96. Opening the doorway to the Future
• Focal target stimulation – frequency, power, duration, phase, duty-
cycle
• Break up phase lock, hyper coherency, strengthen coherency
• Cross-frequency coupling (CFC) – eg. Gamma/Theta
• Modulate selected networks (eg DMN, SN, CEN)
• Precision non-invasive brain intervention
• Customized intervention
• Opportunities for new discoveries
97. Example: Hyper-coherency in Autism can be
broken up
Uncorrected differences in coherence (top row) and phase
lag (bottom row) between ASD and TYP groups during REM
in the four major frequencies.
Note the marked increased in coherences and reductions in
phase lag in the ASD compared to the TYP group. A.W. Buckley et al. / EBioMedicine 2 (2015) 1905–1915
99. One day, we will be able to hack the brain to be fully healthy
Picture credit: Mitchell S. Healthy Brain: How to Avoid Dementia. http://spirit-of-health.com/healthy-brain-how-to-avoid-dementia/
……and take it to a new level
100. Thank you!
Lew Lim, PhD, DNM, MBA
Founder & CEO
Vielight Inc
www.vielight.com
December 7, 2-17
101. Bob Schafer, PhD
Director of Research, Lumos Labs
Lumosity and an Expanding Vision
of Brain Training
103. Lumos Labs, Inc.
50+ games, rooted in science Progress tracking and feedback Personalized, adaptive training
104. Lumos Labs, Inc.
• 4 billion+ game plays
• 85 million+ users worldwide
• 35 million+ mobile app downloads
• 182 countries represented
• 7 languages
Lumosity By The Numbers
105. Lumos Labs, Inc.
Supporting Cognitive Research
Free use of tools and data through the Human
Cognition Project
100+ research collaborators
20+ peer-reviewed publications
Information and applications available at
lumosity.com/HCP
106. Lumos Labs, Inc.
Largest online study of cognitive training
A randomized, active-controlled trial
Hardy et al., PLoS One 2015
107. Lumos Labs, Inc.
Largest online study of cognitive training
A randomized, active-controlled trial
Hardy et al., PLoS One 2015
108. Lumos Labs, Inc.
• Reliability and validity of the
NeuroCognitive Performance
Test
Morrison et al., Frontiers in
Psychology 2015
• Impact of aging and lifestyle on
Lumosity performance
Sternberg et al., Frontiers in
Human Neuroscience 2013
111. Lumos Labs, Inc.
We have billions of data points to
help understand differences in how
people learn, perform, strategize, and
compare.
How can we use this knowledge to
improve Lumosity training?
113. Lumos Labs, Inc.
• Real-time, expert analysis of game
strategy
• Comparison and interpretation of
your cognitive strengths,
tendencies, and biases
• Education and guided practice
around core cognitive and
psychological concepts
115. Lumos Labs, Inc.
Until recently, Lumosity games
focused on core cognitive abilities:
memory, attention, problem solving,
speed, and flexibility.
116. Lumos Labs, Inc.
But mental performance also depends
on knowledge and applied skills.
We applied our game development
process to new areas of training:
Language and Math. Language training
Launched April, 2017
Math training
Launched October, 2017
117. Lumos Labs, Inc.
Language training
• Vocabulary proficiency
• Reading comprehension
• Verbal fluency
Math training
• Quantitative reasoning
• Numerical calculation
• Numerical estimation
• Proportional reasoning
• Probabilistic reasoning
119. Lumos Labs, Inc.
We continually ask Lumosity members
what else in their lives impacts their
mental performance.
We hear common themes: Lumosity
members care deeply about stress and
emotional well-being.
120. Lumos Labs, Inc.
From many candidates, we identified
mindfulness training as a top area to
explore. It has several appealing
qualities:
• Evidence-based
• Enjoyable
• Links to cognitive performance
121. Lumos Labs, Inc.
Mindfulness
Launched December, 2017
Practice concentration, clarity,
and more
Developed with guidance from
leading researchers and
mindfulness teachers
Simple, accessible training