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Dr. Adam
Gazzaley, UCSF Professor of
Neurology, will
present Neuroscape
Dr. Lew Lim, Founder & CEO
of Vielight, will
discuss photobiomodulation as
a new way to enhance brain
function.
Dr. Walter Greenleaf,
Medical VR/ AR Expert
at Stanford Virtual Human
Interaction Lab, will provide
an overview of health
applications of virtual &
augmented reality (VR/AR).
Dr. Bob Schafer, Director of
Research at Lumos Labs, will
present their expanding vision
for brain training,
including mindfulness.
Adam Gazzaley, MD PhD
Founder & Executive Director | Neuroscape
Professor | Neurology, Physiology and Psychiatry
University of California, San Francisco
Co-Founder
Akili Interactive Labs, Sensync & Jazz Venture Partners
Bridging the Gap Between Technology and Neuroscience
neuroscape.ucsf.edu
TECHNOLOGY NEUROSCIENCE CLINICAL EDUCATION
Roger Angera
Director
Interactive Media
Director
Multimodal Biosensing
David Ziegler
Director
Theodore Zanto
Director
Joaquin Anguera
Director
Melina Uncapher
Mobile / Wireless
Technology Program
Virtual Reality Motion Capture
Technology Program
Multimodal Biosensing
Technology Program
• EEG (neural responses)
• GSR/skin conductance (stress)
• Heart Rate Variability (stress)
• Facial expressions (emotion)
• Eye-tracking (attention)
• Pupilometry (arousal & vigilance)
Technology Program
Adaptive Cognitive Evaluation
(ACE)
Body-Brain Trainer
Rhythmicity
Meditrain
Virtual Attention
Engage
Labyrinth
New Games
Body-Brain Trainer
Rhythmicity
Meditrain
Virtual Attention
Engage
Labyrinth
New Games
Transfer Sustainability
Mechanism Heterogeneity
Double-Blinded, Randomized, Placebo-Controlled
• sMRI
• fMRI
• EEG
• GSR
• VO2max
• cognition
• behavior
• stress
• mood
• sleep
• telomeres
• inflammation
• hormones
• enzymes
• genes
Clinical Program
2017
Clinical Program
▸ Attention Deficit Disorder
▸ Depression
▸ Autism
▸ Sensory Processing Disorder
▸ Mild Cognitive Impairment
▸ Traumatic Brain Injury / PTSD
▸ Multiple Sclerosis
▸ Dyslexia
▸ Cancer-Related Cognitive Impairment
▸ Delirium
Active studies in
Neuroscape
Active studies in
collaborate
New studies in
Collaboration
2017
Education Program
• Developed mobile assessments of cognitive control for kids
• Developed mobile assessments of math/reading for kids
• Used these mobile apps to study one of largest populations of in-
school students (N=1,254): 2-yr longitudinal study
• Leveraging population to also study how technology use impacts
cognition and academics.
2018
• Assess how training improves core cognitive capacity
• Assess how training improves academic achievement
• Translate these findings into evidence-based education
Neuroscience Program
• NeuroTech - CHUV [Lausanne, Switzerland]
• COBTEK IA - University Cote d’Azur [Nice, France]
• Benioff Children’s Hospital - UCSF [San Francisco, California]
• Osher Center for Integrative Medicine - UCSF [San Francisco,
California]
• Social Brain in Action Laboratory - Bangor University [Bangor, United
Kingdom]
• Educational Neuroimaging Center - Technion [Haifa, Israel]
Members Benefits
• Participate in fellowship exchange programs
• Establish Neuroscape Research Labs (NRLs)
• Share software/ games
• Leverage access to new technologies
• Access new funding opportunities
• Share best practices for study design
• Perform multi-site clinical trials
Alzheimer’s Disease
Anxiety Disorder
Attention Deficit Disorder
Depression
Post Traumatic Stress Disorder
Autism
Schizophrenia
Traumatic Brain Injury
Parkinson’s Disease
Multiple Sclerosis
Over the Next 10 Years ...
Education
Wellness
Addiction
Thanks for your attention
• Adam Gazzaley
• Ted Zanto
• Joaquin Anguera
• Peter Wais
• Melina Uncapher
• David Ziegler
• Roger Anguera
• Lara Stables
•Jo Gazzaley
• WanYu Hsu
• Courtney Gallen
• Gang Li
• Ilse Pastor
• Yan Wang
• Jaqueline Ayyoub
Core Team
• Sierra Niblett
•AJ Simon
• Meike Gugel
•Josh Volponi
• Juliana Souza
• Jordin Rodondi
• Vinith Johnson
• Richard Campusano
• Alan Duanmu
• Zoe D’Esposito
• Lauren Dacorro
• Olivia Montgomery
• Buddy Lorentz
• Jessica Schactner
• Jesica Youngerneuroscape.ucsf.edu
Financial Support
• National Institute on Aging
• National Institute of Mental Health
• National Science Foundation
• American Federation of Aging Research
• Robert Wood Johnson Foundation
• Zynga.org
• Center 17
• Sandler Foundation
• Tim Ferriss
• Magdalena Yesil
• Feldman Family Foundation
• Grammy Foundation
• Biggelsworth Foundation
• Laney and Pasha Thornton
• Mickey and Caryl Hart
• Pasha and Laney Thornton
• Getty Family
• Ellison Medical Foundation
• Pfizer / Eisai
Industry Partners
• Neuroelectrics
• Akili
• Empatica
• Zynga
• High Fidelity
• Brain Vision
• Apple
• Sony
• NVIDIA
• Meta
• Cognionics
• Qusp
• Sara and Ev Williams
• Elise and Tully Friedman
• Dolby Family
• Roberta and Jamie Gates
• Jeff Stone
Network
• Lounsbery Foundation
• Kavli Foundation
• Posit Science
Transforming HealthCare Through Virtual and
Augmented Reality Technology
Walter Greenleaf PhD
Healthcare Crisis:
Aging Populations
0
50
100
150
200
250
300
350
400
1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 2010 2015 2020 2025
Age 85+
Age 75-84
Age 65-74
Age 45-64
Age 5-44
Under Age 5
Transforming HealthCare with Technology
Digital Health
Revolution
• Mobile Health / eHealth
• Wearable Sensors
• Patient Centered
• Leverages Internet:
social, quantitative, collaborative
Every Medical Device Reinvented
Medical Applications
of Virtual Reality
Technology
Digital Health Revolution
The Quantified
Self Movement
Early Adopters
Digital Health Platforms deliver interventions to patients, and
parse data for enhanced analysis and improved protocols
Dashboards
Physician
Payor
Admin
Wearable
sensors
Mobile
Backend
User auth
Device mgmt
App provisioning
Restful API
Access codes
Messaging
Mail service
Batch/scheduling
Push notification
Analytics
Engagement
RT analytics
Content store
Data tracking
Metrics
Storage Transactional
store
Real time
event store
Data
warehouse
Data store
Infrastructure Log
aggregation
Monitoring
Deployment
agents
SDK
Patient Facing
Applications
Assessments
Reminders
Badges
Interventions
Graphics
data
direction
data
access/analysis
Although entertainment,
social connection and gaming
will drive the initial adoption of
VR technology, the deepest
and most significant market
for VR will be in clinical care
and in improving health and
wellness.
Medical Applications of Virtual Reality Technology
• Current technologies and concepts are founded on more than 30 years of research and development
• Recent changes in cost and access make VR affordable
• VR tech is currently used for prevention, evaluation, treatment and chronic disease management
• After years of validation and use by early adopters - VR technology is poised to move to the
mainstream
• On the horizon: enhanced, ubiquitous, informative and integrated
Virtual Reality Technology For Medicine
• Prevention and Wellness
• Objective Assessments
• Improved Interventions
• Facilitate Adherence
• Distributed Care Delivery
VR and AR technology will significantly impact Medical Care
First general
purpose and
commercially
available VR
systems.
VR Technology Has Evolved
A Personal Journey …
I starting my
research in
VR in
1984
Academic research has indicated that Virtual Reality can effectively treat
a wide variety of clinical problems – ranging from addictions, to stroke,
to PTSD
Treating Post
Traumatic
Stress
With Virtual
Reality
2008 Sichuan
Earthquake
Treating Post
Traumatic
Stress
With Virtual
Reality
2017 Mexico City
Earthquake
Now is the time for VR
VR technology is now affordable, scalable
and accessible to the marketplace. The
VR category is attracting interest and
investments from major players.
Facebook - Oculus
Samsung - GearVR Sony – PlayStation VR
Microsoft - HoloLens
HTC - Vive OSVR
AR Technology
There are
numerous
companies
working in
VR and AR
technology
11.3
16.9
27.3
41.5
56.2
68.0
Year 2 Year 3 Year 4 Year 5 Year 6Year 1
Initial adoption will be driven through
game console, PC gaming and mobile
phone bundling.
Within 3 years, VR will likely be adopted
by 30 million users.
*Based on agent based modeling by
Lieberman Research Worldwide
Within 6 years, VR will likely be adopted by 70 million users
Investments in VR Health Startups
Phobias / PTSD
Stress Management /
Relaxation
Surgical Training /
Planning
Physical
Rehabilitation
Pain Management
Exercise
Cognitive
Rehabilitation
Optical
Rehabilitation
Addictions
Neuropsychological
Assessments
Cognitive Training
Wellness
Sports Training Disability Solutions Speech Therapy
Autism Spectrum
Disorder
Mood Disorders ADHD Senior Care
72 Emerging Medical VR Companies
18 Clinical Sectors
Over 30 years of academic
research and over 3000 studies
demonstrate that VR can
improve behaviors,
attitudes, and health
Until now, the technology was
expensive, bulky, and difficult to use.
Today, we have the advancements to
bring VR to scale in healthcare.
Why Now?
• Medical Interventions
• Clinical Assessments
• Medical Training
• Health & Wellness
MEDICAL APPLICATIONS OF VR
• Clinical Skill Training
• Surgical Skill Training
• Interpersonal Skill Training
• Use of Equipment and Tools
• Team Training - eg: Emergency
Department, Surgical Team
• Emergency Response Training
and Rehearsal
• Empathy
Medical Training
• Medical Image Review
• Neuropsychological
Assessments
• Activities of Daily Living
Assessments
• Physical Medicine – OT / PT
• Behavioral Medicine –
psychology, psychiatry
DIAGNOSTIC ASSESSMENTS
Standardized Environments for Neurocognitive Evaluation
New Approaches for Cognitive Assessment
Migrates traditional paper
and subjective evaluations
to a more sophisticated
level.
Provides robust
assessments that can
challenge cognitive skills in
a more natural,
standardized, objective
and reproducible manner.
• Neuro-Rehabilitation - Stroke and Traumatic Brain Injury
• Physical and Occupational Therapy
• Speech- Language Therapy
• Optical Rehabilitation –
Strabismus, Amblyopia
• Acute and Chronic Pain
• Weight Management
Virtual environments are currently used clinically
to treat several important clinical problems
Here are a few examples -
• Drug and alcohol abuse
• Schizophrenia
• Post-traumatic stress disorder (PTSD)
• Generalized Anxiety Disorder
• Mood Disorders - Depression
• Mild Cognitive Impairment
• Autism Spectrum Disorder
• ADHD
Virtual environments are used clinically to treat several
important mental and behavioral health problems
• Phobia and anxiety disorders
• Obsessive Compulsive Disorder (OCD)
• Developmental disabilities
• Conduct disorders
• Anger management
• Eating disorders
• Impulsive disorders
• Learning disabilities
• Neuro-cognitive disorders
Virtual environments are used clinically to treat several
important mental and behavioral health problems
• Weight Management
• Cognitive Function Training –
Sequencing, Situational Awareness,
Decision Making
• Exercise
HEALTH AND WELLNESS
• Stress Management
• Disability Solutions
• Addressing Isolation
• Grief Counseling
• Mood and Resilience
Portable Telemedicine Platform
Virtual Humans For Training, Confidential Interaction,
and Telemedicine Support
Virtual Humans For Training, Confidential Interaction,
and Telemedicine Support
“Smart Avatar” with a virtual voice,
image and mannerisms via AI
Some Examples
PTSD, Phobias, and Anxiety Disorders
• Exposure-based treatments can be conducted in the safety and comfort of an office
setting
• Effective tools for treating a variety of clinical problems, in particular anxiety and addictive
disorders
• Fully immersive environments, with include the use of a head mounted display, 3D sound,
tactile stimulation via shaking platform, and olfactory stimulus are used for PTSD therapy
Digitized Neurocognitive Evaluation for ADHD
New Approaches for Cognitive Assessment
RISK AVOIDANCE TRAINING
Refusal skill training for those who need help with addictions
Virtual Hospital Tours Used To Relieve Pre-procedure Anxiety
VR for Pain Distraction
Clinical Research and Validation
Interactive virtual environments significantly
reduce pain from as much as 44% during
the most painful procedures
(ex: burn wound treatment)
Diverts patient attention away from perceiving
and feeling pain; (selective attention theory)
Decreases pain-related brain-activity
Reduces need for anesthesia, opioid medication
No pharmacological side effects
Preparation and Training for Difficult Situations
The Neuroscience of How VR Promotes Behavior Change
Ability to change attitudes and behavior after “being” one’s future self.
Leveraging Mirror Neurons
Improved Assessments and Diagnostics
Addressing Isolation and Loneliness
Acute and Chronic Pain
Depression and Anxiety Disorders
Physical and NeuroRehabilitation
Design for Disabilities
Post-Discharge Follow-up
Staff Training: not just procedures, but
empathy
Virtual Environments and Senior Care
• Current technologies and concepts are founded on more than 30 years of research and development
• Recent changes in cost and access make VR affordable
• VR tech is currently used for prevention, evaluation, treatment and chronic disease management
• After years of validation and use by early adopters - VR technology is poised to move to the
mainstream
• On the horizon: enhanced, ubiquitous, informative and integrated
Virtual Reality Technology For Medicine
Transforming HealthCare Through Virtual and
Augmented Reality Technology
Walter Greenleaf PhD
Photobiomodulation:
A new way to enhance brain function
By:
Lew Lim, PhD, DNM, MBA
Founder & CEO
Vielight Inc.
SharpBrains Summit 2017
December 5-7, 2017
Substance-based
Brain Stimulation
Medications and
Synthetic Stimulants
Natural hallucinogens
Nootropics
Caffeine &
Nicotine
Substance-based
Brain Stimulation
Non-invasive Brain
Stimulation Methods
Transcranial Direct Brain Stimulation
Transcranial
Magnetic
Brain
Stimulation
Electroconvulsive Therapy
Non-invasive Brain
Stimulation
Methods
Transcranial Photobiomodulation (PBM)
Molecular and Cellular Mechanisms of PBM
75
Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016 Oct 1;6:113-124. eCollection 2016.
Red and Near-
infrared (NIR) Light
Tissue Modulation in Photobiomodulation
76
Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016 Oct 1;6:113-124. eCollection 2016.
Summary re: Brain Health:
• Restores/repairs
• Maintains
• Enhances
treated many medical brain conditions
In Human studies:
• Stroke
• Traumatic brain injury
• Alzheimer’s disease /
dementia
• Coma
• Depression and anxiety
In Animal studies:
• Parkinson’s disease
• Multiple sclerosis
In peer-reviewed literature, PBM has
Red/NIR Light Mitigates Alzheimer’s in Lab
Animals
Purushothuman S, et al (2014). Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models Alzheimer's Research &
Therapy. 6:2
Sources:
Taboada LD, et al (2011). Transcranial Laser Therapy Attenuates Amyloid- Peptide Neuropathology in Amyloid- Protein Precursor Transgenic Mice. Jnl. Alz. Dis. 521-535.
Theories and Evidence support a Wearable
Photobiomodulation Device for Alzheimer’s
Saltmarche AE, et al. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal
Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017 Aug 1; 35(8): 432–441
The Default Mode Network is targeted
Comprehensive response is achieved while maintaining wearability
Photobiomodulation produces Significant
Improvement in Dementia Patients
Mean MMSE Change from Baseline
Light
Processor: Visual Cortex
Picture: Discovery Eye Foundation. The Optic Nerve and its Visual Link to the Brain
Pulsing Light at 40 Hz (Gamma) Reduces β-amyloid
Load in the Visual Cortex
Based on: Iaccarino HF, Singer AC, Martorell AJ, et al (2016). Gamma frequency
entrainment attenuates amyloid load and modifies microglia. Nature 540(7632): 230-
235.
Intranasal Projection to Memory Processors
Source: Wedge Therapeutics. SONS Olfactory Relays
Case Report
of Random
Patient
(MMSE 21)
treated with
PBM at 40 Hz
Caregiver Report 3 Weeks with Neuro Gamma
Short term EEG Changes in Alzheimer Patient with Neuro Gamma
Upcoming Clinical Trials for Alzheimer’s with Gamma
Non-medical Brain Enhancement
Examples:
• Mindfulness and consciousness
• Reaction time
• Memory retrieval
• Cognition
Brain Response to PBM Validated with EEG
Before After
20 minutes
Gamma (40 Hz) Elevates Fast Brainwaves and
Downregulates Slow Brainwaves
(Pending publication)
Transcranial PBM
Enhances Cerebral
Oxygenation
Tian F, Hase AN, Gonzalez-Lima F, et al. Transcranial Laser Stimulation Improves Human Cerebral Oxygenation. 2016. Lasers Surg Med. 48:343-349.
Cognition
Increased Gamma in High-level Meditation
Transcranial PBM Improves Reaction Time
Grover F, Weston J, Weston M. Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures. 2016. Photomed Las
Surg.
DMS: Delayed Match-to-sample
Gonzalez-Lima F, Barrett DW. Augmentation of cognitive brain functions with transcranial lasers. 2014. Frontiers Sys Neurosc.
8(36)
Transcranial PBM Improves Speed and
Accuracy of Memory Retrieval
The Near Future:
The Neuro Pro (in Prototype):
Controlling each parameter
Opening the doorway to the Future
• Focal target stimulation – frequency, power, duration, phase, duty-
cycle
• Break up phase lock, hyper coherency, strengthen coherency
• Cross-frequency coupling (CFC) – eg. Gamma/Theta
• Modulate selected networks (eg DMN, SN, CEN)
• Precision non-invasive brain intervention
• Customized intervention
• Opportunities for new discoveries
Example: Hyper-coherency in Autism can be
broken up
Uncorrected differences in coherence (top row) and phase
lag (bottom row) between ASD and TYP groups during REM
in the four major frequencies.
Note the marked increased in coherences and reductions in
phase lag in the ASD compared to the TYP group. A.W. Buckley et al. / EBioMedicine 2 (2015) 1905–1915
Automated
Intervention
The Future: Automated Intervention
EEG Analysis
One day, we will be able to hack the brain to be fully healthy
Picture credit: Mitchell S. Healthy Brain: How to Avoid Dementia. http://spirit-of-health.com/healthy-brain-how-to-avoid-dementia/
……and take it to a new level
Thank you!
Lew Lim, PhD, DNM, MBA
Founder & CEO
Vielight Inc
www.vielight.com
December 7, 2-17
Bob Schafer, PhD
Director of Research, Lumos Labs
Lumosity and an Expanding Vision
of Brain Training
Lumos Labs, Inc.
Ten Years of Lumosity
Lumos Labs, Inc.
50+ games, rooted in science Progress tracking and feedback Personalized, adaptive training
Lumos Labs, Inc.
• 4 billion+ game plays
• 85 million+ users worldwide
• 35 million+ mobile app downloads
• 182 countries represented
• 7 languages
Lumosity By The Numbers
Lumos Labs, Inc.
Supporting Cognitive Research
Free use of tools and data through the Human
Cognition Project
100+ research collaborators
20+ peer-reviewed publications
Information and applications available at
lumosity.com/HCP
Lumos Labs, Inc.
Largest online study of cognitive training
A randomized, active-controlled trial
Hardy et al., PLoS One 2015
Lumos Labs, Inc.
Largest online study of cognitive training
A randomized, active-controlled trial
Hardy et al., PLoS One 2015
Lumos Labs, Inc.
• Reliability and validity of the
NeuroCognitive Performance
Test
Morrison et al., Frontiers in
Psychology 2015
• Impact of aging and lifestyle on
Lumosity performance
Sternberg et al., Frontiers in
Human Neuroscience 2013
Lumos Labs, Inc.
Evolution of Lumosity
Lumos Labs, Inc.
Insights
Lumos Labs, Inc.
We have billions of data points to
help understand differences in how
people learn, perform, strategize, and
compare.
How can we use this knowledge to
improve Lumosity training?
Lumos Labs, Inc.
Insights
Launched November, 2016
Lumos Labs, Inc.
• Real-time, expert analysis of game
strategy
• Comparison and interpretation of
your cognitive strengths,
tendencies, and biases
• Education and guided practice
around core cognitive and
psychological concepts
Lumos Labs, Inc.
Language & Math
Lumos Labs, Inc.
Until recently, Lumosity games
focused on core cognitive abilities:
memory, attention, problem solving,
speed, and flexibility.
Lumos Labs, Inc.
But mental performance also depends
on knowledge and applied skills.
We applied our game development
process to new areas of training:
Language and Math. Language training
Launched April, 2017
Math training
Launched October, 2017
Lumos Labs, Inc.
Language training
• Vocabulary proficiency
• Reading comprehension
• Verbal fluency
Math training
• Quantitative reasoning
• Numerical calculation
• Numerical estimation
• Proportional reasoning
• Probabilistic reasoning
Lumos Labs, Inc.
Mindfulness
Lumos Labs, Inc.
We continually ask Lumosity members
what else in their lives impacts their
mental performance.
We hear common themes: Lumosity
members care deeply about stress and
emotional well-being.
Lumos Labs, Inc.
From many candidates, we identified
mindfulness training as a top area to
explore. It has several appealing
qualities:
• Evidence-based
• Enjoyable
• Links to cognitive performance
Lumos Labs, Inc.
Mindfulness
Launched December, 2017
Practice concentration, clarity,
and more
Developed with guidance from
leading researchers and
mindfulness teachers
Simple, accessible training
Lumos Labs, Inc.
An Expansion of Lumosity
Brain Training
Lumos Labs, Inc.
TaskSwitching
ResponseInhib.
SpatialReasoning
Planning
LogicalReasoning
SelectiveAttn.
DividedAttn.
FieldofView
SpatialRecall
WorkingMemory
FaceNameRecall
Info.Processing
SpatialOrientation
Visualization
Flexibility
Problem
Solving
Attention
Memory
Speed
Cognition
Ten years of learning has helped
Lumosity evolve from basic
cognitive training to something
much richer…
Lumos Labs, Inc.
TaskSwitching
ResponseInhib.
SpatialReasoning
Planning
LogicalReasoning
SelectiveAttn.
DividedAttn.
FieldofView
SpatialRecall
WorkingMemory
FaceNameRecall
Info.Processing
SpatialOrientation
Visualization
VerbalFluency
VerbalProficiency
ReadingComp.
Vocab.Proficiency
Arithmetic
Statistics
Fractions
Estimation
Concentration
Clarity
Friendliness
Flexibility
Problem
Solving
Attention
Memory
Speed
Language
Math
Mindfulness
Cognition Knowledge
Lumos Labs, Inc.
The next ten years of Lumosity begin with
richer training,
new training areas, and
personalized, data-driven insights.
Lumos Labs, Inc.
Questions?
Thank you, Speakers & Participants!
Thank you, Summit Sponsors!
Thank you, Summit Partners!
To learn more, visit sharpbrains.com

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Expo Day: UCSF, Stanford, VieLight & Lumos Labs

  • 1.
  • 2.
  • 3. Dr. Adam Gazzaley, UCSF Professor of Neurology, will present Neuroscape Dr. Lew Lim, Founder & CEO of Vielight, will discuss photobiomodulation as a new way to enhance brain function. Dr. Walter Greenleaf, Medical VR/ AR Expert at Stanford Virtual Human Interaction Lab, will provide an overview of health applications of virtual & augmented reality (VR/AR). Dr. Bob Schafer, Director of Research at Lumos Labs, will present their expanding vision for brain training, including mindfulness.
  • 4. Adam Gazzaley, MD PhD Founder & Executive Director | Neuroscape Professor | Neurology, Physiology and Psychiatry University of California, San Francisco Co-Founder Akili Interactive Labs, Sensync & Jazz Venture Partners Bridging the Gap Between Technology and Neuroscience
  • 6. TECHNOLOGY NEUROSCIENCE CLINICAL EDUCATION Roger Angera Director Interactive Media Director Multimodal Biosensing David Ziegler Director Theodore Zanto Director Joaquin Anguera Director Melina Uncapher
  • 8. Virtual Reality Motion Capture Technology Program
  • 9. Multimodal Biosensing Technology Program • EEG (neural responses) • GSR/skin conductance (stress) • Heart Rate Variability (stress) • Facial expressions (emotion) • Eye-tracking (attention) • Pupilometry (arousal & vigilance)
  • 13. Transfer Sustainability Mechanism Heterogeneity Double-Blinded, Randomized, Placebo-Controlled • sMRI • fMRI • EEG • GSR • VO2max • cognition • behavior • stress • mood • sleep • telomeres • inflammation • hormones • enzymes • genes Clinical Program
  • 14. 2017 Clinical Program ▸ Attention Deficit Disorder ▸ Depression ▸ Autism ▸ Sensory Processing Disorder ▸ Mild Cognitive Impairment ▸ Traumatic Brain Injury / PTSD ▸ Multiple Sclerosis ▸ Dyslexia ▸ Cancer-Related Cognitive Impairment ▸ Delirium Active studies in Neuroscape Active studies in collaborate New studies in Collaboration
  • 15. 2017 Education Program • Developed mobile assessments of cognitive control for kids • Developed mobile assessments of math/reading for kids • Used these mobile apps to study one of largest populations of in- school students (N=1,254): 2-yr longitudinal study • Leveraging population to also study how technology use impacts cognition and academics. 2018 • Assess how training improves core cognitive capacity • Assess how training improves academic achievement • Translate these findings into evidence-based education
  • 17. • NeuroTech - CHUV [Lausanne, Switzerland] • COBTEK IA - University Cote d’Azur [Nice, France] • Benioff Children’s Hospital - UCSF [San Francisco, California] • Osher Center for Integrative Medicine - UCSF [San Francisco, California] • Social Brain in Action Laboratory - Bangor University [Bangor, United Kingdom] • Educational Neuroimaging Center - Technion [Haifa, Israel] Members Benefits • Participate in fellowship exchange programs • Establish Neuroscape Research Labs (NRLs) • Share software/ games • Leverage access to new technologies • Access new funding opportunities • Share best practices for study design • Perform multi-site clinical trials
  • 18. Alzheimer’s Disease Anxiety Disorder Attention Deficit Disorder Depression Post Traumatic Stress Disorder Autism Schizophrenia Traumatic Brain Injury Parkinson’s Disease Multiple Sclerosis Over the Next 10 Years ... Education Wellness Addiction
  • 19. Thanks for your attention
  • 20. • Adam Gazzaley • Ted Zanto • Joaquin Anguera • Peter Wais • Melina Uncapher • David Ziegler • Roger Anguera • Lara Stables •Jo Gazzaley • WanYu Hsu • Courtney Gallen • Gang Li • Ilse Pastor • Yan Wang • Jaqueline Ayyoub Core Team • Sierra Niblett •AJ Simon • Meike Gugel •Josh Volponi • Juliana Souza • Jordin Rodondi • Vinith Johnson • Richard Campusano • Alan Duanmu • Zoe D’Esposito • Lauren Dacorro • Olivia Montgomery • Buddy Lorentz • Jessica Schactner • Jesica Youngerneuroscape.ucsf.edu
  • 21. Financial Support • National Institute on Aging • National Institute of Mental Health • National Science Foundation • American Federation of Aging Research • Robert Wood Johnson Foundation • Zynga.org • Center 17 • Sandler Foundation • Tim Ferriss • Magdalena Yesil • Feldman Family Foundation • Grammy Foundation • Biggelsworth Foundation • Laney and Pasha Thornton • Mickey and Caryl Hart • Pasha and Laney Thornton • Getty Family • Ellison Medical Foundation • Pfizer / Eisai Industry Partners • Neuroelectrics • Akili • Empatica • Zynga • High Fidelity • Brain Vision • Apple • Sony • NVIDIA • Meta • Cognionics • Qusp • Sara and Ev Williams • Elise and Tully Friedman • Dolby Family • Roberta and Jamie Gates • Jeff Stone Network • Lounsbery Foundation • Kavli Foundation • Posit Science
  • 22. Transforming HealthCare Through Virtual and Augmented Reality Technology Walter Greenleaf PhD
  • 23.
  • 24. Healthcare Crisis: Aging Populations 0 50 100 150 200 250 300 350 400 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 2010 2015 2020 2025 Age 85+ Age 75-84 Age 65-74 Age 45-64 Age 5-44 Under Age 5
  • 26. Digital Health Revolution • Mobile Health / eHealth • Wearable Sensors • Patient Centered • Leverages Internet: social, quantitative, collaborative
  • 27. Every Medical Device Reinvented
  • 28. Medical Applications of Virtual Reality Technology Digital Health Revolution
  • 30. Digital Health Platforms deliver interventions to patients, and parse data for enhanced analysis and improved protocols Dashboards Physician Payor Admin Wearable sensors Mobile Backend User auth Device mgmt App provisioning Restful API Access codes Messaging Mail service Batch/scheduling Push notification Analytics Engagement RT analytics Content store Data tracking Metrics Storage Transactional store Real time event store Data warehouse Data store Infrastructure Log aggregation Monitoring Deployment agents SDK Patient Facing Applications Assessments Reminders Badges Interventions Graphics data direction data access/analysis
  • 31. Although entertainment, social connection and gaming will drive the initial adoption of VR technology, the deepest and most significant market for VR will be in clinical care and in improving health and wellness. Medical Applications of Virtual Reality Technology
  • 32. • Current technologies and concepts are founded on more than 30 years of research and development • Recent changes in cost and access make VR affordable • VR tech is currently used for prevention, evaluation, treatment and chronic disease management • After years of validation and use by early adopters - VR technology is poised to move to the mainstream • On the horizon: enhanced, ubiquitous, informative and integrated Virtual Reality Technology For Medicine
  • 33. • Prevention and Wellness • Objective Assessments • Improved Interventions • Facilitate Adherence • Distributed Care Delivery VR and AR technology will significantly impact Medical Care
  • 34. First general purpose and commercially available VR systems. VR Technology Has Evolved
  • 35. A Personal Journey … I starting my research in VR in 1984
  • 36.
  • 37. Academic research has indicated that Virtual Reality can effectively treat a wide variety of clinical problems – ranging from addictions, to stroke, to PTSD
  • 40. Now is the time for VR VR technology is now affordable, scalable and accessible to the marketplace. The VR category is attracting interest and investments from major players. Facebook - Oculus Samsung - GearVR Sony – PlayStation VR Microsoft - HoloLens HTC - Vive OSVR
  • 42.
  • 44. 11.3 16.9 27.3 41.5 56.2 68.0 Year 2 Year 3 Year 4 Year 5 Year 6Year 1 Initial adoption will be driven through game console, PC gaming and mobile phone bundling. Within 3 years, VR will likely be adopted by 30 million users. *Based on agent based modeling by Lieberman Research Worldwide Within 6 years, VR will likely be adopted by 70 million users
  • 45. Investments in VR Health Startups
  • 46. Phobias / PTSD Stress Management / Relaxation Surgical Training / Planning Physical Rehabilitation Pain Management Exercise Cognitive Rehabilitation Optical Rehabilitation Addictions Neuropsychological Assessments Cognitive Training Wellness Sports Training Disability Solutions Speech Therapy Autism Spectrum Disorder Mood Disorders ADHD Senior Care 72 Emerging Medical VR Companies 18 Clinical Sectors
  • 47. Over 30 years of academic research and over 3000 studies demonstrate that VR can improve behaviors, attitudes, and health Until now, the technology was expensive, bulky, and difficult to use. Today, we have the advancements to bring VR to scale in healthcare. Why Now?
  • 48. • Medical Interventions • Clinical Assessments • Medical Training • Health & Wellness MEDICAL APPLICATIONS OF VR
  • 49. • Clinical Skill Training • Surgical Skill Training • Interpersonal Skill Training • Use of Equipment and Tools • Team Training - eg: Emergency Department, Surgical Team • Emergency Response Training and Rehearsal • Empathy Medical Training
  • 50. • Medical Image Review • Neuropsychological Assessments • Activities of Daily Living Assessments • Physical Medicine – OT / PT • Behavioral Medicine – psychology, psychiatry DIAGNOSTIC ASSESSMENTS
  • 51. Standardized Environments for Neurocognitive Evaluation New Approaches for Cognitive Assessment Migrates traditional paper and subjective evaluations to a more sophisticated level. Provides robust assessments that can challenge cognitive skills in a more natural, standardized, objective and reproducible manner.
  • 52. • Neuro-Rehabilitation - Stroke and Traumatic Brain Injury • Physical and Occupational Therapy • Speech- Language Therapy • Optical Rehabilitation – Strabismus, Amblyopia • Acute and Chronic Pain • Weight Management Virtual environments are currently used clinically to treat several important clinical problems Here are a few examples -
  • 53. • Drug and alcohol abuse • Schizophrenia • Post-traumatic stress disorder (PTSD) • Generalized Anxiety Disorder • Mood Disorders - Depression • Mild Cognitive Impairment • Autism Spectrum Disorder • ADHD Virtual environments are used clinically to treat several important mental and behavioral health problems
  • 54. • Phobia and anxiety disorders • Obsessive Compulsive Disorder (OCD) • Developmental disabilities • Conduct disorders • Anger management • Eating disorders • Impulsive disorders • Learning disabilities • Neuro-cognitive disorders Virtual environments are used clinically to treat several important mental and behavioral health problems
  • 55. • Weight Management • Cognitive Function Training – Sequencing, Situational Awareness, Decision Making • Exercise HEALTH AND WELLNESS • Stress Management • Disability Solutions • Addressing Isolation • Grief Counseling • Mood and Resilience
  • 57. Virtual Humans For Training, Confidential Interaction, and Telemedicine Support
  • 58. Virtual Humans For Training, Confidential Interaction, and Telemedicine Support “Smart Avatar” with a virtual voice, image and mannerisms via AI
  • 60. PTSD, Phobias, and Anxiety Disorders • Exposure-based treatments can be conducted in the safety and comfort of an office setting • Effective tools for treating a variety of clinical problems, in particular anxiety and addictive disorders • Fully immersive environments, with include the use of a head mounted display, 3D sound, tactile stimulation via shaking platform, and olfactory stimulus are used for PTSD therapy
  • 61. Digitized Neurocognitive Evaluation for ADHD New Approaches for Cognitive Assessment
  • 62. RISK AVOIDANCE TRAINING Refusal skill training for those who need help with addictions
  • 63. Virtual Hospital Tours Used To Relieve Pre-procedure Anxiety
  • 64. VR for Pain Distraction Clinical Research and Validation Interactive virtual environments significantly reduce pain from as much as 44% during the most painful procedures (ex: burn wound treatment) Diverts patient attention away from perceiving and feeling pain; (selective attention theory) Decreases pain-related brain-activity Reduces need for anesthesia, opioid medication No pharmacological side effects
  • 65. Preparation and Training for Difficult Situations
  • 66. The Neuroscience of How VR Promotes Behavior Change
  • 67. Ability to change attitudes and behavior after “being” one’s future self. Leveraging Mirror Neurons
  • 68. Improved Assessments and Diagnostics Addressing Isolation and Loneliness Acute and Chronic Pain Depression and Anxiety Disorders Physical and NeuroRehabilitation Design for Disabilities Post-Discharge Follow-up Staff Training: not just procedures, but empathy Virtual Environments and Senior Care
  • 69. • Current technologies and concepts are founded on more than 30 years of research and development • Recent changes in cost and access make VR affordable • VR tech is currently used for prevention, evaluation, treatment and chronic disease management • After years of validation and use by early adopters - VR technology is poised to move to the mainstream • On the horizon: enhanced, ubiquitous, informative and integrated Virtual Reality Technology For Medicine
  • 70. Transforming HealthCare Through Virtual and Augmented Reality Technology Walter Greenleaf PhD
  • 71. Photobiomodulation: A new way to enhance brain function By: Lew Lim, PhD, DNM, MBA Founder & CEO Vielight Inc. SharpBrains Summit 2017 December 5-7, 2017
  • 72. Substance-based Brain Stimulation Medications and Synthetic Stimulants Natural hallucinogens Nootropics Caffeine & Nicotine Substance-based Brain Stimulation
  • 73. Non-invasive Brain Stimulation Methods Transcranial Direct Brain Stimulation Transcranial Magnetic Brain Stimulation Electroconvulsive Therapy Non-invasive Brain Stimulation Methods
  • 75. Molecular and Cellular Mechanisms of PBM 75 Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016 Oct 1;6:113-124. eCollection 2016. Red and Near- infrared (NIR) Light
  • 76. Tissue Modulation in Photobiomodulation 76 Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016 Oct 1;6:113-124. eCollection 2016. Summary re: Brain Health: • Restores/repairs • Maintains • Enhances
  • 77. treated many medical brain conditions In Human studies: • Stroke • Traumatic brain injury • Alzheimer’s disease / dementia • Coma • Depression and anxiety In Animal studies: • Parkinson’s disease • Multiple sclerosis In peer-reviewed literature, PBM has
  • 78. Red/NIR Light Mitigates Alzheimer’s in Lab Animals Purushothuman S, et al (2014). Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models Alzheimer's Research & Therapy. 6:2 Sources: Taboada LD, et al (2011). Transcranial Laser Therapy Attenuates Amyloid- Peptide Neuropathology in Amyloid- Protein Precursor Transgenic Mice. Jnl. Alz. Dis. 521-535.
  • 79. Theories and Evidence support a Wearable Photobiomodulation Device for Alzheimer’s Saltmarche AE, et al. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017 Aug 1; 35(8): 432–441
  • 80. The Default Mode Network is targeted Comprehensive response is achieved while maintaining wearability
  • 81. Photobiomodulation produces Significant Improvement in Dementia Patients Mean MMSE Change from Baseline
  • 82. Light Processor: Visual Cortex Picture: Discovery Eye Foundation. The Optic Nerve and its Visual Link to the Brain Pulsing Light at 40 Hz (Gamma) Reduces β-amyloid Load in the Visual Cortex Based on: Iaccarino HF, Singer AC, Martorell AJ, et al (2016). Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 540(7632): 230- 235.
  • 83. Intranasal Projection to Memory Processors Source: Wedge Therapeutics. SONS Olfactory Relays
  • 84. Case Report of Random Patient (MMSE 21) treated with PBM at 40 Hz
  • 85. Caregiver Report 3 Weeks with Neuro Gamma
  • 86. Short term EEG Changes in Alzheimer Patient with Neuro Gamma
  • 87. Upcoming Clinical Trials for Alzheimer’s with Gamma
  • 88. Non-medical Brain Enhancement Examples: • Mindfulness and consciousness • Reaction time • Memory retrieval • Cognition
  • 89. Brain Response to PBM Validated with EEG Before After 20 minutes
  • 90. Gamma (40 Hz) Elevates Fast Brainwaves and Downregulates Slow Brainwaves (Pending publication)
  • 91. Transcranial PBM Enhances Cerebral Oxygenation Tian F, Hase AN, Gonzalez-Lima F, et al. Transcranial Laser Stimulation Improves Human Cerebral Oxygenation. 2016. Lasers Surg Med. 48:343-349. Cognition
  • 92. Increased Gamma in High-level Meditation
  • 93. Transcranial PBM Improves Reaction Time Grover F, Weston J, Weston M. Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures. 2016. Photomed Las Surg.
  • 94. DMS: Delayed Match-to-sample Gonzalez-Lima F, Barrett DW. Augmentation of cognitive brain functions with transcranial lasers. 2014. Frontiers Sys Neurosc. 8(36) Transcranial PBM Improves Speed and Accuracy of Memory Retrieval
  • 95. The Near Future: The Neuro Pro (in Prototype): Controlling each parameter
  • 96. Opening the doorway to the Future • Focal target stimulation – frequency, power, duration, phase, duty- cycle • Break up phase lock, hyper coherency, strengthen coherency • Cross-frequency coupling (CFC) – eg. Gamma/Theta • Modulate selected networks (eg DMN, SN, CEN) • Precision non-invasive brain intervention • Customized intervention • Opportunities for new discoveries
  • 97. Example: Hyper-coherency in Autism can be broken up Uncorrected differences in coherence (top row) and phase lag (bottom row) between ASD and TYP groups during REM in the four major frequencies. Note the marked increased in coherences and reductions in phase lag in the ASD compared to the TYP group. A.W. Buckley et al. / EBioMedicine 2 (2015) 1905–1915
  • 98. Automated Intervention The Future: Automated Intervention EEG Analysis
  • 99. One day, we will be able to hack the brain to be fully healthy Picture credit: Mitchell S. Healthy Brain: How to Avoid Dementia. http://spirit-of-health.com/healthy-brain-how-to-avoid-dementia/ ……and take it to a new level
  • 100. Thank you! Lew Lim, PhD, DNM, MBA Founder & CEO Vielight Inc www.vielight.com December 7, 2-17
  • 101. Bob Schafer, PhD Director of Research, Lumos Labs Lumosity and an Expanding Vision of Brain Training
  • 102. Lumos Labs, Inc. Ten Years of Lumosity
  • 103. Lumos Labs, Inc. 50+ games, rooted in science Progress tracking and feedback Personalized, adaptive training
  • 104. Lumos Labs, Inc. • 4 billion+ game plays • 85 million+ users worldwide • 35 million+ mobile app downloads • 182 countries represented • 7 languages Lumosity By The Numbers
  • 105. Lumos Labs, Inc. Supporting Cognitive Research Free use of tools and data through the Human Cognition Project 100+ research collaborators 20+ peer-reviewed publications Information and applications available at lumosity.com/HCP
  • 106. Lumos Labs, Inc. Largest online study of cognitive training A randomized, active-controlled trial Hardy et al., PLoS One 2015
  • 107. Lumos Labs, Inc. Largest online study of cognitive training A randomized, active-controlled trial Hardy et al., PLoS One 2015
  • 108. Lumos Labs, Inc. • Reliability and validity of the NeuroCognitive Performance Test Morrison et al., Frontiers in Psychology 2015 • Impact of aging and lifestyle on Lumosity performance Sternberg et al., Frontiers in Human Neuroscience 2013
  • 111. Lumos Labs, Inc. We have billions of data points to help understand differences in how people learn, perform, strategize, and compare. How can we use this knowledge to improve Lumosity training?
  • 113. Lumos Labs, Inc. • Real-time, expert analysis of game strategy • Comparison and interpretation of your cognitive strengths, tendencies, and biases • Education and guided practice around core cognitive and psychological concepts
  • 115. Lumos Labs, Inc. Until recently, Lumosity games focused on core cognitive abilities: memory, attention, problem solving, speed, and flexibility.
  • 116. Lumos Labs, Inc. But mental performance also depends on knowledge and applied skills. We applied our game development process to new areas of training: Language and Math. Language training Launched April, 2017 Math training Launched October, 2017
  • 117. Lumos Labs, Inc. Language training • Vocabulary proficiency • Reading comprehension • Verbal fluency Math training • Quantitative reasoning • Numerical calculation • Numerical estimation • Proportional reasoning • Probabilistic reasoning
  • 119. Lumos Labs, Inc. We continually ask Lumosity members what else in their lives impacts their mental performance. We hear common themes: Lumosity members care deeply about stress and emotional well-being.
  • 120. Lumos Labs, Inc. From many candidates, we identified mindfulness training as a top area to explore. It has several appealing qualities: • Evidence-based • Enjoyable • Links to cognitive performance
  • 121. Lumos Labs, Inc. Mindfulness Launched December, 2017 Practice concentration, clarity, and more Developed with guidance from leading researchers and mindfulness teachers Simple, accessible training
  • 122. Lumos Labs, Inc. An Expansion of Lumosity Brain Training
  • 125. Lumos Labs, Inc. The next ten years of Lumosity begin with richer training, new training areas, and personalized, data-driven insights.
  • 127. Thank you, Speakers & Participants!
  • 128. Thank you, Summit Sponsors!
  • 129. Thank you, Summit Partners!
  • 130. To learn more, visit sharpbrains.com