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Do our Genes Determine What We Should Eat? 2016

  1. Ahmed El-Sohemy Department of Nutritional Sciences University of Toronto Canada Research Chair in Nutrigenomics Nutrigenomix Inc. Toronto – Sydney Santiago – São Paulo Chief Scientific Officer Do our genes determine what we should eat? The evolution of personalized nutrition
  2. Diet Genes Using genetic information and genomic technologies to investigate how nutrients interact with our genome to impact our health and performance. Food preferences The Science of Nutrigenomics
  3. Increase Decrease No Effect Genes Genotype A Genotype C Genotype B Health OutcomeNutrition Why bother with genetics/genomics? One size does not fit all
  4. Increase Decrease No Effect Genes Genotype A Genotype C Genotype B CVDCoffee Is Coffee associated with CVD?
  5. caffeine magnesium potassium polyphenols aliphatic acids diterpenoids melanoidins Bioactives in Coffee
  6. Caffeine (1,3,7-trimethylxanthine)
  7. “The Legal Alternative”
  8. Caffeine CYP1A2 1-methylxanthine 1-methyluric acid 5-acetylamino-6- formylamino-3- methyluracil 1,7-dimethyluric acid Paraxanthine
  9. AA AC CC 0 50 100 150 200 250 300 CYP1A2 Genotype %Inducibility slow fast Genetic Variation in CYP1A2 -163 AC
  10. 0.5 1.0 1.5 2.0 <1 cup/d 1 cup/d 2-3 cups/d 4 cups/d Total Population OddsRatio * * P<0.05 Cornelis et al., JAMA 295: 1135-41, 2006 Coffee Intake and Risk of Heart Attacks
  11. Coffee Intake and Risk of Heart Attacks AA AC + CC 0 1 2 3 4 <1 cup/d 1 cup/d 2-3 cups/d 4 cups/d CYP1A2 Genotype OddsRatio Subjects <50 Years of Age * P<0.05 * * * * Cornelis et al., JAMA 295: 1135-41, 2006
  12. AA AC + CC 0 1 2 3 4 Abstainers 1-3 cups/day 4 cups/day CYP1A2 Genotype HazardRatio Palatini et al., J Hypertens 27: 1594-1601, 2009 Coffee Intake and Risk of Hypertension * P<0.05 * * *
  13. Coffee Intake and Risk of Pre-Diabetes
  14. Personalized Dietary Advice Public Health Recommendations vs
  15. “There are spectacular metabolic differences in people, and to expect that coffee will have the same health effects on everyone is absurd,” - Dr. Sander Greenland Professor Emeritus, Epidemiology UCLA
  16. “Unfortunately, because genetic testing is expensive and rarely done, most people have little idea which gene variant they carry.” - Panel Member
  17. USA, 2007-2012 UK/USA, 2000 - 2009 USA, 2007-?? USA, 2009 Canada, 2009-2012 Iceland, 2007-2012 USA, 2006 USA, 2007 USA, 2001 Australia, 2008-2013 USA, 2000 UK, 2010 Consumer Genetic Tests Canada, 2011
  18. Does genetic information influence behaviour?
  19.  DNA-based dietary advice resulted in:  greater understanding of recommendations  greater interest in learning more  greater motivation to change eating habits
  20.  Greater compliance after 1 year.  DNA-based dietary advice is superior to the one-size-fits-all general recommendations
  21. Did you share the information in the report with anyone? 0% 25% 50% 75% 100% Control Intervention p < 0.001 * * *
  22. Which source do you feel would provide you with the most accurate personal genetic information? 0% 25% 50% 75% 100% University Research Lab Healthcare Professional DTC Genetic Testing Company Control Intervention p = 0.56
  23. Saliva collected into vial: Quick, non-invasive procedure How Nutrigenomix® Works
  24. 7-Gene Test 45-Gene Test Gluten Test (2012) (2016) (2014) Sample Reports
  25. Covering these 7 aspects of health: New 45-Gene Test
  26. Sample Report
  27. Null Functional 0 10 20 30 40 <RDA Meets RDA GST-T genotype SerumAscorbicAcid (mol/L) Caucasians Null Functional 0 10 20 30 40 GST-T Genotype SerumAscorbicAcid (mol/L) East Asians Vitamin C Intake GST-T Genotype and Serum Ascorbic Acid Deficiency P=0.001 for diet-gene interaction P=0.02 for diet-gene interaction Cahill et al, Am J Clin Nutr, 2009 20% null 50% null
  28. Starter Package for Clinics
  29. Distributors  China  Hong Kong  Macau  Brazil  Chile  United Kingdom  United Arab Emirates  Kuwait  Israel
  30. Coming Soon
  31. Is DNA-based Dietary Advice Ready for Prime Time? • Scientific evidence is robust (studies replicated) • Information is actionable and “personalized” • Increasing consumer awareness and demand • Improved compliance (evidence from RCT) • Focus on wellness/prevention, not disease treatment • Independent of ethnic background Yes
  32. “…making day-to-day decisions about what to eat based on their particular genetic makeup.” ~1/3 of consumers will focus on personalized nutrition
  33. Products developed for your genetics
  34. - Hippocrates (480 BC) “Positive health requires a knowledge of man’s primary constitution and of the powers of various foods, both those natural to them and those resulting from human skill.” Personalized Nutrition Genotype
  35. Website: Email: Ahmed El-Sohemy, PhD (click below to watch video) Chief Scientific Officer Nutrigenomix Inc. 1-800-250-4NGX Contact Information
  36. Asian Food Regulation Information Service is a resource for the food industry. We have the largest database of Asian food regulations in the world – and it’s FREE to use. We publish a range of communication services (free and paid), list a very large number of food events and online educational webinars and continue to grow our Digital Library. Feel free to contact us anytime to talk about your specific requirements, offer comments, complaints or to compliment us. We look forward to hearing from you soon!