1. ADIPOSE TISSUE AS AN
ENDOCRINE ORGAN
By:

2. ADIPOSE TISSUE
BROWN
ADIPOSE
TISSUE
WHITE
ADIPOSE
TISSUE

3. o Adipose tissue:
• White adipose tissue (WAT): stores energy
• Brown adipose tissue (BAT: generates body heat
3

4. The most significant physiological functions of WAT
4

5. Adipose tissue as an endocrine organ
5

6. 6

7. 7

8. o Very little is known about the potential function of resistin.
8

9. o Visfatin have insulino-mimetic action:
 Because it bind insulin receptors at a site that differs
from that of insulin and reduces blood glucose level.
9

10. Adipose tissue is the primary storage site for excess energy but it
is also recognized as an endocrine organ. Adipocytes are now
generally accepted to be a complex cell type
generating a number of signals which include
hormones and growth factors that not
involved in
cytokines,
affect the
only
neighboring cells but also impact target tissues
involved in energy metabolism and influencing physiologic and
pathologic processes.
40

11. 11

12. Scheja, Ludger; Heeren, Joerg (September 2019). "The endocrine
function of adipose tissues in health and cardiometabolic disease".
Nature Reviews Endocrinology. 15 (9): 507–524.
doi:10.1038/s41574-019-0230-6
Ge, Tongtong; Fan, Jie; Yang, Wei; Cui, Ranji; Li, Bingjin (26
October 2018). "Leptin in depression: a potential therapeutic target".
Cell Death & Disease. 9 (11): 1096. doi:10.1038/s41419-018-1129-
1. PMC 6203758. PMID 30367065
Coelho, Marisa; Oliveira, Teresa; Fernandes, Ruben (2013-04-20).
"Biochemistry of adipose tissue: an endocrine organ". Archives of
Medical Science. 9 (2): 191–200. doi:10.5114/aoms.2013.33181
REFERENCES