Description of neoplasm & anti neoplastic drugs.

2. A =Anticancer drugs cause N =Nausea and vomiting T =Treatment regimen must be followed I =Individualized dosage N =New drugs appear on the market E =Exposure time kept to a minimum O =Only a physician can administer P =Protect yourself L =Look, listen, and learn A =Assessment of laboratory tests S =Safe dosage based on weight T =Toxicities I =Inform patients C =Classification of agents

4. Warning Signs of Neoplasm C hanges in bowel or bladder habits A sore that will not heal U nusual bleeding, discharge T hickening or lump in breast or elsewhere I ndigestion, difficulty swallowing O bvious change in wart or mole N agging cough, hoarseness

6. Classification

12. Drug Affecting Nucleic Acid Synthesis Hydroxyurea Drug Destroying DNA Structure & its Function Antitumor Antibiotics Cisplatin & carboplantin Alkylating Agent Camptothecins

13. Drugs interfering with transcription Dactinomycin Doxorubicin Daunorubicin Drugs affecting protein synthesis L - Asparaginase Podophyllotoxin : Teniposide & Etoposide Taxanes : Taxol & Taxotere Vincristine & Vinblastin

14. Alkylating agents Produce Highly reactive carbonium Ion which transfer alkyl group to position 7 of guanine by the covalent bond.

23. Epipodophyllotoxin Etoposide: Semi synthetic derivative of podophyllotoxin. It arrest the cells in G2 phase & cause the DNA breaks by affecting the DNA topoisomerase II function . Use: testicular tumor, lung cancer, Hodgkin's disease. Dose: 50-100 mg /day oral for 5 days. Branded Name: Peltasol 100 mg in 5 ml inj.

30. Hormones Glucocorticoids Primarily used in childhood acute leukemia & lymphomas . Secondary effect in Breast cancer Anti Androgen Palliative effect in advanced / metastatic cases because it increase the androgen level. Antiestrogen Effective in positive estrogen receptor as well as negative breast cancer in postmenopausal women. Estrogens Use in carcinoma of male breast. 120-240 mg orally. 5  reductase inhibitor Inhibit the conversion of testosterone to dihydrotestosterone GnRH agonists Indirectly inhibit the secretion of androgen /estrogen by suppressing the FSH & LH has effect on prostate/breast Progestin Use in temporary remission in some cases of advanced & metastatic endometrial carcinoma