9. Disturbing Statistics
• Between 1973 and 1999 Cancer deaths increased 30% (17.7% -23% of
population)
• For the first time (2005), cancer has surpassed heart disease as the top killer
of Americans under 85….” (Los Angeles Times, Jan. 19, 2005
• 1.3 million diagnosed and 570,000 die annually in US
• In the 25-35 year old age group a recent analysis of the National Cancer
Institute statistic showed that survival rates have not increased at all since
1975
“Cancer is the leading disease killer in people age 20 to 39…..more than
70,000 young adults get cancer every year……”
The Wall Street Journal, July 5, 2005, page D1
10. No Refined Carbohydrates!
“Fuel for the Fire”
• 2001 US per Capita Consumption: 170 lbs/year
• 1820 US per capita Consumption: 10-20 lbs/year
11. Sugar = Insulin
• Cancer Cells have 6-15 X Insulin Receptor
Sites
• Insulin Directs Inflammatory Eicosanoids
Pathways
12. “The Metabolism of Carcinoma Cells”
by Otto Warburg
The Journal of Cancer Research
Volume 9, pg 148-163 (1925)
16. CANCER & CLA
•1996 Study of 4,697
Women: The More Whole
Fat Milk in the Diet (More
CLA) = Lower Risk of
Breast Cancer. Women
Drinking the Most Milk
Had a 60% Lower Risk of
Breast Cancer
•Rats Fed 1.5% of
Calories as CLA = Tumor
Size Reduced 60%
•Dr. Tikal Dhiman at Utah
State University: One Can
Lower Cancer Risk by
Consuming Daily, One
Ounce of Cheese, One
Serving of Grassfed Meat
& One Glass of Whole
Milk From Pastured
Cattle.
19. Resveratrol
“Of All the Plants We’ve Tested For Cancer Chemo- Preventive Activity, and The
Compounds We’ve Seen, This Has the Greatest Promise”
(University of Illinois-Chicago)
• Significantly Reduce Tumor Volume (42%), Tumor Weight (44%) and
Metastasis (56%) in Mice w/Highly Metastasized Lung Cancer
• Induced Apoptosis in Human Leukemia Cells; Stopped Growth of
Lymphocytic Leukemia
• Inhibits NF-kB
• Anti-Cancer For Hormone Dependent and Independent Breast Cancers
• Inhibits COX-2
• Restored Glutathione
• Increase Levels of Phase II Detoxification (Quinone Reductase)
• Dose: 20-50-mg/Day
20. CURCUMIN
• Increases Production TGF-beta (Transforming Growth Factor)
Producing Apoptosis
• Increases Expression of Nuclear p53 Protein in Basal Cell Carcinomas,
Hepatomas & Leukemia, Producing Apoptosis
• Inhibits PTK (Protein Tyrosine Kinases) and PKC (Protein Kinase C),
Which Relay Chemical Signals for Proliferation, Metastases,
Angiogenesis, Differentiation, Avoidance of Apoptosis
• Inhibits COX-2
• Inhibits Nuclear Factor-Kappa B (NF-kB)
• Dose 900 mg Capsules 1-3x/Day
22. Carotenoid Study
25,802 Adults in Maryland
• High Levels of beta carotene & alpha
tocopherol = decreased cancer risk
• Persons with highest tier of total
carotenoids = 66% reduction in cancer risk
versus lowest tier
Cancer Res 1993 Feb 15; 53(4): 795-8
23. Vitamin D (Cholecalciferol)
• “Potential impact far greater than influenza
vaccine”- Dr. Scott Dowell (US CDC
11/26/06- Baltimore Sun)
• Vitamin D produces anti-biotic peptides via
white cells
• 200,000 IU’s for (3) days
• Ideal Blood Levels 25 hydroxy vitamin D:
70-80 ng/mL
24. Cancer Risk Reduction & Vitamin D Status
Cancer
Risk Reduction with
Increased Vitamin D Intake
Breast 50%
Colon 50%
Prostate 49%
Ovary 36%
Recent Results Cancer Res. 2007. 174:225-34; J. Steroid
Biochem Mol Biol. 2007 Mar; 103 (3-5); 708-11; J Steroid
Biochem Mol Biol. 2005 Oct; 97(1-2):179-94; Cancer Res. 2005
June 15; 65 (12); 5470-9; Cancer Epidemial Biomarkers Prev.
2004 Sept. 13 (9): 1502-8.
25. Vitamin D Cancer Mechanisms
• Affects at least 200 human genes, including those
controlling
– Proliferation
– Differentiation
– Apoptosis
– Angiogenesis
– Metastasis
• 89 identified studies showing vitamin D intake reduces
cancers of breast, prostate, colon, esophagus, pancreas,
ovary, rectum, bladder, kidney, lung and uterus – Life
Extension October 2007
26. American Journal of Clinical Nutrition
2007 Jun; 85(6): 1586-91
“Vitamin D and Calcium Supplementation
Reduces Cancer Risks”
• 1180 Post Menopausal Women
• 1000 IU’s Vitamin D/day for (4) years
– 60% Lower Cancer Risk
– 77% Lower Cancer Incidence when excluding
cancers in first year of study
• Vitamin D & Calcium = best outcomes
27. SELENIUM
• Potentiates Chemotherapy for Prostate & Colon Cancer
• Drew University of Medicine and Science
– Significant Increase in Apoptosis and Decrease in DNA Synthesis in
Cancers of Breast, Lung, Small Intestines, Colon and Liver
• 10 Year Study on 1312 Subjects
– Prostate Cancer Reduced 63%
– Colon Rectal Cancer Reduced 58%
– Lung Cancer Reduced 46%
• Dose: Use Se-Methylselenocysteine: and Selenium Yeast: 400-600
mcg/day. Take with Vitamin E (Tocotrienols and Gamma Tocopherol)
400-800 IU/day
28. IODINE
• Japanese: Lowest Level of Breast, Uterine Ovarian and Prostate Cancer
• Daily Japanese Iodine Consumption: 14-100 mg
• U.S. R.D.A.: 150-200 mcg
• Maintaining Iodine Sufficiency : 13 mg/Day
– 6 mg Thyroid
– 5 mg Breast
– 2 mg Rest of Body
• Displaces Bromine (Carcinogen)
• Chelates Metals and Other Toxins
• Destroys Parasites, Yeast, Bacteria, Virus
• Promotes Stomach Acidity
• Helps Hypo and Hyper Thyroidism
• Prevents, Reverses Hashimoto’s and Grave’s
• Reduces Lipoprotein (a)
• Misc. : Headaches; Parotid Duct Stones; Keloid Formation; Peyronies
Contractures; Breast, Ovarian, & Skin Cysts
29. I3C (INDOLE 3 CARBINOL)
• Inhibits Growth of Estrogen- Receptor Positive Breast Cancer Cells by 90% vs.
Tamoxifen @ 60%
• Stops Human Cancer Cells From Growing (54-61%) and Initiated Apoptosis
• Increases Conversion of Estradiol to Estriol by 50% in (1) Week (12 Subjects)
• Prevented Aflatoxin Induced Liver Cancer, Leukemia, Colon Cancer &
Chemically Induced Breast Cancer 70-96% (Lab Rats)
• Restores p21 and Other Proteins That Correct Adducts (Tamoxifen No Effect)
• Hoechst Marrion Roussel: New Generation of Indole Drugs to Replace Estrogen
Drugs
• Dose 200 mg 2-4x / Day As Per Body Wt.
35. CO-Q10 (Ubiquinol)
400-600 mg
• University of Miami
• Significantly reduces expression of bcl-2 gene
(resistance to apoptosis) of cancer cells
• Remission of metastasized breast cancer- 1994
European Study
• Rats on Tamoxifen: 3 X increase in tumor weight
• Rats of Tamoxifen & Co-Q10: No increase in
tumor weight
– Restored SOD, Catalase, Glutathione
36. Vitamin E Complex
800 IU/day
• Need all tocopherols (alpha, beta,
gamma delta)
• Inhibit cycloxygenase 2 (COX)
enzyme
• Neutralizes reactive nitrogen oxides
• Reduces oxidation of LDL and fats
• Reduces Leukotrine b4 and TNF-@
• Finnish study of 29,000 PC patients
(smokers) for 5-8 years: 32%
decrease; 40% decrease in mortality
37. Vitamin A
100,000-300,000 IU/day
• Secretory IgA = Immunity of
Mucosal Tissue
• 14 month trial, 181 patients with
post-surgical non-small lung cancer
– 300,000 IU/day
– Relapses: 18% vs 28% (controls)
• After 46 months, rates of tumor
reoccurrence/new tumors
– 37% (treated) versus 48% controls
Journal of Clinical Oncology
1993; 11(7): 1216-22
38. Green Tea
• Polyphenols (Epigallocatechin gallate EGCG)
• Elevates Caspase 3 Enzyme (Apoptosis)
• Inhibits Invasilon
• Inhibits metastasis
• Stimulates Immunity
• Free Radical Scavenger (greater than Vitamin E)
– E.g. Mice with melanoma & lung carcinoma cells-
number of tumors decreased 50% and 29%
• Inhibits interaction between estrogen and estrogen
receptors (prostate and breast cancer)
39. ARTEMINISIN
Artemisia Annua or Sweet Wormwood
• University of Washington Drs. Henry Lai and Narerida Singh
• Int’l Journal of Oncology 18; 767-773, 2001
• Peroxide Linkage Attacks “Free” Iron (Cancer and Malaria)
– Releases Free Radicals; Destroys Cells
• All Cancers Respond- No resistance!
• Active Ingredients
– Artesunate: Water Soluble, Most Active, Shortest Half Life
– Artemisinin: Intermediate Half Life
– Artemether: Fat Soluble, Most Toxic, Longest Half Life
• 500 mg Twice Daily on Empty Stomach w/ Whole Milk or Cod Liver Oil (Fat)
• Take for (2) Years
Nutricology
800-545-9960
www.nutri-cology.com
41. Proceedings of National Academy of Science USA
Volume 73, No. 10 pp 3685-3689 October 1976
by E. Cameron and L. Pauling
• All Patients were determined to be terminal;
ascorbate only administered to
“untreatable” patients
– Treated Group: 10 grams ascorbate I.V. for 10
days; orally thereafter
– Matched Controls: No Treatment
42. Average Survival Times and ratios for Ascorbate & Matched Controls
A
Type of Cancer (X)
# of ascorbate
B
Ascorbate
(Days)
C
Control
(Days)
D
Ratio
B/C
E
Ave Day
survival
both goups
F
%
Ascorbate
surviving >
E
G
% Controls
Surviving >
E
Bronchus (15) 136 38.5 3.53 47 47 8.7
Colon (13) 282 37 7.61 59 54 20
Stomach (13) 99 38 2.61 43 46 19
Breast (11) 367 64 53-.75 91 55 22
Kidney (9) 333 64 5.21 88 67 22
Bladder (7) 196 43.6 4.49 57 57 20
Rectum (7) 226 55.5 4.10 71 86 33
Ovary (6) 148 71 2.08 78 83 30
Others (19) 172 56.8 3.03 67 53 27
All (100) 209 50.4 4.16 65 60 25.7
16% of Ascorbate patients survived in excess of (1) year, vs. 0.3% of controls (53X)
44. Difference in Average Survival Times of Ascorbate-Treated Patients & Matched Controls
Primary
Tumor Type
Patient No.
Test Control
From First Hospital
Attendance
A B
Test Control
From Date of
Untreatability
C D
Test Control
Increased Survival Times
of Ascorbate Treated
patients, days
E F
A-B C-D
Colon 17 170 458(+) 316 352(+) 33 142(+) 319(+)
Bronchus 17 170 219(+) 118 186(+) 31 101(+) 155(+)
Stomach 13 130 286(+) 159 182(+) 32 127(+) 150(+)
Breast 11 110 1369(+) 1020 487(+) 52 376(+) 435(+)
Kidney 8 80 774(+) 492 38(+) 39 282(+) 342(+)
Bladder 7 70 1669(+) 420 355(+) 21 1249(+) 334(+)
Rectum 7 70 634 336 270 43 298 227
Ovary 6 60 884 366 183 69 518 114
Other 14 140 706(+) 279 278(+) 37 427(+) 241(+)
All 100 1000 681(+) 360 293(+) 38 321(+) 255(+)
Mean Survival Times, Days
(+) indicates one patient in group
survived after May 15, 1978
45. The Center for the Improvement of
Human Functioning
The Late Dr. Hugh Riordan (M.D.) Founder 1975
Wichita, Kansas, 67219 (RECNAC)
www.brightspot.org (316) 682-3100
•20 Published papers on Vitamin C & Cancer
•RECNAC II University of Puerto Rico
“Orthomolecular Oncology Review: Ascorbic Acid &
Cancer 25 Years Later”
46. Ascorbate Findings by RECNAC
• Animals synthesize Vitamin C from glucose
in only (4) metabolic steps
• Cancer cells readily absorb and accumulate
ascorbate (similar to glucose molecule?)
Vitamin CGlucose
47. • At adequate concentrations (400+ mg/dl)
Vitamin C is selectively toxic to cancer cells
• Vitamin C behaves as pro-oxidant
– Interacts with intracellular Fe & Cu
– Reaction produces H2O2
– Cancer cells are deficient in catalase
Ascorbate Findings by RECNAC
48. IV Vitamin C Boost Immunity
Ascorbate Findings by RECNAC
49. • IV Vitamin C inhibits hyaluronidase
• IV Vitamin C Corrects scurvy in Cancer Patients
• IV Vitamin C induces apoptosis
• IV Vitamin C reduces pain
• IV Vitamin C neutralizes chemo and radiation
toxicity without neutralizing their cancer killing
effects
• IV Vitamin C helps cancer patients recover faster
from treatments and disease
Ascorbate Findings by RECNAC
51. IV Vitamin C
Stimulates Collagen
Formation Via
Hydroxylation of
Proline
Ascorbate
Findings by
RECNAC
52. Benefits of Additional Vitamins
• Adding Vitamin B-12 create cytotoxic
cobalt ascorbate
• Adding Lipoic Acid “recycles” ascorbate to
maintain plasma saturations and increase
sensitivity of cancer cells to ascorbate
• Adding Vitamin K-3 (menadione) recycles
DHA (Dihydro ascorbate)
53. RECNAC Vitamin C Case Histories
52 year old female- Renal Cell Carcinoma
• Diagnosed 9/95
• 9/96- (8) 1-3 cm lung metastasis
– No prior treatment
– 10/96 IV Vitamin C- 65 gms bi-weekly plus NAC, beta
1,3 glucan, fish oil EPA, vitamin C (9 gms/day), beta-
carotene, L-threonine, niacin, chromium, Bacillus
laterospores
• Treatments until June 1997. 7 masses resolved.
Large reduction of 8th mass.
• Four years later (2001), no evidence of
progression
54. 70 Year Male- Renal Carcinoma
• Diagnosed 12/85
• Radical nephrectomy; Xrays/CT: multiple
pulmonary & liver lesions. No chemotherapy
decided
– March 1986- IAA, 30 gms 2X/week
– April 1986 (6 weeks treatment): complete resolution of
lung, liver and lymph node metastasis
– 1986: 30 gms IAA 2X/week for 7 months; reduced to
1X/week for 8 months; reduced to 15 gm IAA 1X week
for six months
– Patient expired 12 years later, cancer free at age 82
RECNAC Vitamin C Case Histories
56. Cimetidine
The Lancet, 1979 (pp. 822-823) USA
• University of Nebraska- Two Patients
1. Squamous cell carcinoma metastasis to lung
2. Non small cell lung cancer metastasis to brain
1. 1200 mg/day Cimetidine for stomach distress
• Reduced to 600 mg/day cimetidine
• One year later, no detectable tumor
2. 600 mg/day Cimetidine & steroids (brain swelling)
• Brain tumor excised, one year later no long tumor
57. The Lancet 1982ii (p 328) Ireland
• Four Stage IV Melanoma patients (mets to
liver and lung)
– 1000 mg/day Cimetidine & Coumadin
– Three patients: dramatic remissions
– One patient: death
– All four patients had T-suppressor cells
decreased by Cimetidine
58. New England Journal of Medicine
1983, Vol. 308, pp 591-592 Sweden
• Cimetidine
– Six Melanoma Patients (Interferon &
Cimetidine)
• 2 complete remissions
• 1 partial remission
• 1 progression arrested
• 2 deaths
59. The Lancet
December 31, 1994 pp 1768-1769 Australia
• Cimetidine given (7) days only at time of
surgery
• Three year survival
• Cimetidine: 93% (T-cell infiltration into tumors:
63%)
• Controls: 59% (T-cell infiltration into tumors:
24%)
60. The Lancet (Colorectal Cancer)
Dec 24-31, 1994; 344 (8939-8940)
• Cimetidine given for 5 days pre & 2 days
post operative
• Decrease 3 year mortality rate from 41% to
7%
61. British Journal of Cancer
2002 (86) 161-167
• Dukes Grade C Aggressive Colon Caner
• 10 Year Study with 15 Japanese Institutions
– Treated patients given 800 mg Cimetidine/day for
12 months
– Treated 10 year survival rate: 84.6%
– Control 10 year survival rate: 23.1%
62. The Lancet
December 12, 1987 pp 1371-1374 European Stroke
Prevention- Two year study
– No benefits from Aspirin Alone
– With Dipyridamole: Stroke reduced 50%,
myocardial infarction reduced 38%, cancer
reduced 30%
– Boehringer Ingelheim (original patent holder): no
longer advise M.D.’s that dipyridamole prevents
cancer cells from attaching to vascular system
(metastasis)
Dipyridamole
63. The Lancet
March 23, 1985 p 692
Dr. E.H. Rhodes, St. Hiler and Kingman Hospital in
Surrey, England
• 30 Melanoma Patients
– 300 mg/day Dipyridamole: 11 year study
• 26 patients: Stage IV
– 5 year survival = 74%
– English Average = 32%
• 4 patients: Stage III
– 5 year survival = 100%
64. The Lancet
October 17, 1964 Canada
pp 832-835
“Cancer Incidence and Mortality in Patients Having
Anticoagulant Therapy”
• L. Michaels (student of O.Meara) studied 1500
“patient years” of patients on Coumadin
– Statistical expectation of 8 deaths from cancer
– Only 1 death detected (lung cancer)
65. New England Journal of Medicine
February 25, 1982 p. 484 Sweden
Bjorn Stenkvist M.D., University Hospital, Uppsala, Sweden
Digitalis
• 149 Breast Cancer Patients
• 40 on Digitalis
– 34 Digitoxin
– 6 Digoxin
• 109 Controls
• 5 year outcomes
– Digitalis Patients: 1 re-occurrence (2.5%)
– Controls: 21 re-occurrences (19.25%)
• Observation: Digitalis made breast
cancer cells smaller and more uniform
66. Medical Hypotheses 1999 53 (6)
Johan Haux M.D. Institute of Cancer Research and Molecular
Biology, Norwegian University for Science and Technology,
Trondiem, Norway
• Digitalis
– Anti-Cancer effect of digitalis is induction of
apotosis
– Digitoxin (natural) has greater anti-cancer effect
than digoxin (synthetic)
– Effective for Glioblastoma
– Cost is < $2.00/day!
76. Center for the Study of Natural Oncology
Vince Gammill N.D.
vgammill@adelphia.net
858-523-9144
San Diego Clinic
Filiberto Munoz M.D.
Tijuana, Mexico
619-804-7783
77. Resources
• Weston A. Price Foundation
www.westonaprice.org
• Life Extension Foundation www.lef.org
• People Against Cancer (Ralph Moss)
www.peopleagainstcancer.com
• Cancer Control Society
• www.preventcancer.com (Dr. Samuel
Epstein)