The above Twain quotes aren't his most famous. You can find those anywhere. What follows are some of Twain's ideas that relate to leadership, leaders, and business. I'll leave it to you to see how they connect to modern problems of management & efficiency.
2. The primary rule of business success is loyalty to your employer. That's all right--as a theory. What is the matter with loyalty to yourself? - Speeches
3. Do something every day that you don't want to do; this is the golden rule for acquiring the habit of doing your duty without pain. - Following the Equator
4. He had discovered a great law of human action, without knowing it--namely, in order to make a man or a boy covet a thing, it is only necessary to make the thing difficult to attain. - The Adventures of Tom Sawyer
5. ...our best built certainties are but sand-houses & subject to damage from any wind of doubt that blows. .- The Great Dark
6. When I am king, they shall not have bread & shelter only, but also teachings out of books, for a full belly is little worth where the mind is starved. - The Prince and the Pauper
8. No word was ever as effective as a rightly timed pause. .- Speeches
9. When a person cannot deceive himself the chances are against his being able to deceive other people. -Autobiography
10. Let us be thankful for the fools; but for them the rest of us could not succeed. .- Following the Equator
11. Noise proves nothing. Often a hen who has merely laid an egg cackles as if she had laid an asteroid. - Following the Equator
12. Man is the only animal that blushes. Or needs to. - Following the Equator
13. There are two times in a man's life when he should not speculate: when he can't afford it, & when he can. - Following the Equator
14. Let your sympathies & your compassion be always with the under dog in the fight--this is magnanimity; but bet on the other one--this is business. - Autobiography
15. Do not put off until tomorrow what can be put off till day-after-tomorrow just as well. - More Maxims of Mark
16. From the beginning of my sojourn in this world there was a persistent vacancy in me where the industry ought to be. - Autobiography
17. Thousands of geniuses live & die undiscovered--either by themselves or by others. - Autobiography
18. Rise early. It is the early bird that catches the worm. Don't be fooled by this absurd saw; I once knew a man who tried it. He got up at sunrise and a horse bit him. - Notebooks