My lecture at the Broad Institute on 1/10/13. Online at http://www.youtube.com/watch?v=ACL01EkqleY

2. three hypotheses.

3. hypothesis A:

4. cheap data changes the
epistemology of fields.

5. what makes justified
beliefs justified?
http://plato.stanford.edu/entries/epistemology/

7. player x is a good hitter
because

8. OPS = AB(H + BB +
HBP) + TB(AB + BB + SF
+ HBP) / AB(AB + BB +
SF + HBP)

9. fields based on narrative, but
tested in reality, are very
vulnerable to data-driven
change.

11. information > gut
models and metrics
low transaction costs
pissed off pundits

13. hypothesis B:

14. data is (becoming) cheap
enough to drive epistemic
change in health.

16. not just cheap, but
potentially democratized.

20. not just democratized, but
ubiquitous.

23. hypothesis C:

24. costs will not magically
decline thanks to data.

25. 25

26. 26

27. 27

28. 28

29. 29

30. assume 1,000,000 downloads
assume 10% false positive rate
100,000 doctor visits
$1000 per biopsy

33. that s the setup.

35. sharing by small but
coherent groups can
create asymmetrically
valuable resources.

38. small group
sharing

39. coherentism from:
standard legal tools
common infrastructure
norms
metadata

41. proven to work in:
software
content

42. the experiment:

43. let s a small but
coherent group to
share data and see if it
works in health.

47. http://opensnp.org/users/615

48. http://files.snpedia.com/reports/promethease_data/genome_jtw_ui2.html

50. Also there is no suggestion of
consanguinity in your pedigree.
http://www.ianlogan.co.uk/

52. http://sagebridge.org

53. 53

54. PLC:
portable legal consent

56. terms in blue pop up definitions

58. all boxes must be checked
volunteer must click to proceed

59. volunteer cannot skip video

64. http://weconsent.us/informed-
consent/
64

65. moving PLC to an open
consent standard.

66. email
patient
#XYZ123
researcher patient

67. Public
Portable
Legal
Sage
Bionetworks Sage
Bionetworks
Recruitment Consent CGRE Synapse
Founda3on
Advocacy
CGRE
Database Synapse
Database
1 2 Portable
Legal
Consent 3 4 5
Individual
Level
De-­‐iden3fied
Hospital
Data Dataset
Researchers
Founda3on
Advocacy
Par3cipants

68. 3
Portable
Legal
Consent
2
Advocacy
Advocacy
Founda3on Hospital Founda3on
Par3cipants
1

71. 71

72. five clinical studies on
Bridge this year under
PLC.

74. it s likely that we will
end up with a sharing
monopoly of some
sort.

75. once entrenched, hard to
move.

76. once entrenched, hard to
move.

77. tendency to increment.

82. a. just like now,
but moreso

84. b. the cartel.

86. c. the commons.

88. only the last choice
allows all three
choices to exist.

90. thank you
@wilbanks
john.wilbanks@sagebase.org