graphics based slides created for teaching by webzmedlectures

1. Webzmedlectures
WML
DISORDERS AFFECTING
HEMOSTASIS

2. DEFINITION

3. HOW DOES THE BODY
REPSOND TO THIS?

4. ANSWER

5. TECHNICALLY
• WHAT IS HEMOSTASIS: It is a complex
physiological respond of the body to insult
brought about by bleeding,based on the
interaction of :
• Plasma factors
• Thrombocytes or platelets
• Blood vessel.

6. STAGES OF HEMOSTASIS

7. CLOTH DISSOLUTION

8. VESSEL SPASM

10. HOW DOES IT HAPPEN
(SPASM OF VESSELS)
• 1. The endothelial cells send information
to the smooth muscle cell and this causes
their contraction.
• Information is related to the smooth to the
nerve innervation of the smooth muscle

11. PLATELET PLUG FORMATION

12. ORIGINATE FROM
MEGAKARYOCYTES

13. STEPS IN PLUG FORMATION
• PLATELETS ACTIVATION
• ADHESION OF LATELETS
• AGGREGATION OF PLATELETS.

14. PLATELET ACTIVATION
• Factors that activate platelets are release
from their cytoplasm, and they include
• 1.ADP
• 2.Serotonin
• 3.PDGF, (platelet derived growth factor)
• Platelet factor 4

15. WHAT HAPPEN WHEN THEY
ARE ACTIVATED?
• When platelets are activated they change
their shape from a disc shape to a
spherical shape
• This change of shape helps them to obtain
the ability to adhere and aggregate.

16. ADHESION

17. AGGREGATION

18. We get the platelet plug or the
primary hemostatic plug.

19. COAGULATION CASCADE
• Main purpose is to stabilize and
strengthens the platelet plug
• To form the fibrin mesh that give that
stability required.

20. Definition
• Coagulation cascade is a complex
biological process that leads to the
conversion of soluble plasma fibrinogen to
fibrin.
• 3 main stages
• -formation of thromboplastine comlex
• -transformation of prothrombin to
Thrombin
.-transformation of fibrinogen to fibrin

21. Factors INVOLVED

22. THEIR INTERACTIONS

23. LIMITATION OF
COAGULATION
• It is a good thing that this process is
restricted to the particular region involve in
the insult,this is achieved by inhibitors of
activated coagulation factors, and
fibrinolysis

24. FIBRINOLYTIC SYSTEM
• This process leads to the restoration of
vessel potency, that is the continuity of the
vessel.

25. HOW IT HAPPENS !!