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Journal reading: Acute Lung injury and the acute respiratory distress syndrome ： a clinical review Lancet 2007; 369: 1553–65 Arthur P Wheeler, Gordon R Bernard ,[object Object],[object Object],[object Object]
Content ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Definition & diagnosis
Simplified consensus definition of acute lung injury ,[object Object],[object Object],[object Object],[object Object],[object Object]
CXR of ARDS
Causes of acute lung injury : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differential diagnosis of ARDS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Histopathology & Pathophysiology ,[object Object],[object Object]
Progress and Staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Progress and Staging ,[object Object],[object Object],[object Object],[object Object]
 
Acute stage :exudative phase ,[object Object],[object Object],[object Object],[object Object]
Acute stage :exudative phase ,[object Object],[object Object]
Acute stage :exudative phase ,[object Object],[object Object],[object Object],[object Object]
Chronic stage: Fibroproliferative phase ,[object Object],[object Object]
 
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Supportive care ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanical ventilation: high Tv ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanical ventilation: low Tv ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Effects of PEEP ,[object Object],[object Object]
Higher & lower PEEP in patients with ARDS ,[object Object],[object Object],[object Object],[object Object],[object Object],ARDS Network. Higher versus lower positive end expiratory pressures in patients with acute respiratory distress syndrome. N Engl J Med 2004; 351: 327–36.
Effects of PEEP ,[object Object],[object Object]
Prone positioning ,[object Object],[object Object],[object Object],[object Object],[object Object]
Prone positioning ,[object Object],[object Object],[object Object]
Corticosteroids ,[object Object],[object Object],[object Object]
Efficacy and Safety of Corticosteroids for Persistent ARDS ,[object Object],[object Object],[object Object],N Engl J Med 2006;354:1671-84.
Results ,[object Object],[object Object]
Results ,[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object]
Extracorporeal support ,[object Object]
Fluid management ,[object Object],[object Object],[object Object]
Comparison of Two Fluid-Management Strategies in Acute Lung Injury ,[object Object],[object Object],[object Object],(NEJM 354;24 June 15, 2006)
(NEJM 354;24 June 15, 2006)
(NEJM 354;24 June 15, 2006)
Results ,[object Object],[object Object],(NEJM 354;24 June 15, 2006)
Vasodilators ,[object Object],[object Object],[object Object],[object Object]
Unproven treatments for acute respiratory distress syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object]

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