Y2 s1 pain physiology

Physiology of pain Prof. Vajira Weerasinghe Professor in Physiology, Faculty of Medicine University of Peradeniya & Consultant Neurophysiologist, Teaching Hospital, Peradeniya

Topics covered in the lecture ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What is pain? ,[object Object],[object Object],[object Object],[object Object],[object Object]

What is pain? ,[object Object],[object Object]

What is pain? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dual nature of pain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Different situations

Pain ,[object Object],[object Object],[object Object],[object Object]

Stimuli ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptors ,[object Object],[object Object],[object Object],[object Object]

Nerve pathways carrying pain signals to the brain ,[object Object],[object Object],[object Object]

afferent fibres ,[object Object],[object Object],[object Object]

central connections ,[object Object],[object Object],[object Object],substantia gelatinosa Neurotransmitter at the first synapse of the pain pathway is substance P

[object Object],[object Object],ascending pathway Pain lateral spinothalamic tract C fibre substantia gelatinosa

lateral spinothalamic tract thalamus sensory cortex C fibre thalamocortical tracts

Pain perception ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Descending pain modulatory system ,[object Object],[object Object],[object Object],[object Object],[object Object]

midbrain pons medulla spinal cord periaqueductal grey nucleus nucleus raphe magnus substantia gelatinosa

opioid peptides ,[object Object]

opioid peptides ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

receptors ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],sensory cortex C fibre

Gate control theory ,[object Object],[object Object],[object Object]

Gate control theory When pain fibre is stimulated, gate will be opened & pain is felt pain pain is felt + gate is opened

Gate control theory When pain and touch fibres are stimulated together, gate will be closed & pain is not felt pain is not felt touch pain + - gate is closed

Gate control theory ,[object Object],[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

Y2 s1 pain physiology

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Y2 s1 pain physiology