Stem Cells And Potential Clinical Applications

Stem cells and potential clinical applications รศ . อาทิตย์ อังกานนท์ ภาควิชาอายุรศาสตร์ คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี มหาวิทยาลัยมหิดล

Embryo development http :// www . youtube . com / watch?v = mUcE1Y_bOQE

Capabilities of stem cell ,[object Object],[object Object]

Promise of stem cells research Regenerative Medicine . Department of Health and Human Services. August 2006.

Stem cell heirachy One kind of tissue Monopotent stem cells Tissues in same germ layer Multipotent stem cells Embryo Pleuripotent stem cells Embryo and placenta Totipotent stem cells Capability of development Type of stem cells

Sources of stem cells ,[object Object],[object Object],[object Object],[object Object],[object Object]

Reprogramming Scientific Breakthrough of the Year 2008 (Science Magazine) Mature, specialized adult cells Induced Pleuripotent Stem Cells (ES cells liked) Four genes inserted Patient specific cells ,[object Object],[object Object],Another type of specialized cells Pancreatic exocrine cells to beta cells

Do stem cells exist in adult? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Why bone marrow? http :// stemcells . nih . gov / info / scireport / chapter5 . asp

Stem cell enrichment ,[object Object],[object Object]

Potentials ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hematopoietic stem cell transplantation ,[object Object],[object Object],[object Object]

Concept ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Allogeneic transplantation ,[object Object],[object Object],[object Object],[object Object]

HLA system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HLA system inheritance พ่อ แม่

HLA compatibility ผู้ป่วย HLA identical Haploidentical Unidentical

Donor อื่น นอกเหนือจากพี่น้อง ,[object Object],[object Object],[object Object],[object Object]

การใช้ BMT เป็น supportive measure ,[object Object],[object Object],[object Object],[object Object]

Procedure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Stem cell collection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Indications of HSCT ,[object Object],[object Object],[object Object],[object Object],[object Object]

Immunosuppression ,[object Object],[object Object],[object Object],[object Object]

Post transplantation ,[object Object],[object Object],[object Object],[object Object],[object Object]

Graft versus host disease ,[object Object],[object Object],[object Object],[object Object]

Chimerism – the beauty of HSCT ,[object Object],[object Object],[object Object]

The Graft-versus-”Disease” Effect ,[object Object],[object Object],[object Object]

HSCT offers beyond the effects of chemotherapy ,[object Object],[object Object],[object Object]

Potential in CardioVascular Diseases ,[object Object],[object Object]

Potential sources of stem cells used for heart diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Lunde, et al (Norway) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Assmus, et al (Frankfurt Germany) ,[object Object],[object Object],[object Object],[object Object]

Schachinger, et al (Frankfurt Germany) ,[object Object],[object Object],[object Object],[object Object]

Other approach ,[object Object],[object Object]

Unanswered questions ,[object Object],[object Object],[object Object],There is definitely a role of stem cells in cardiac repair.

Stem cells and nervous system ,[object Object],[object Object],[object Object],[object Object]

Potential in Neurologic diseases ,[object Object],[object Object],[object Object],[object Object],[object Object]

Parkinson’s disease ,[object Object],[object Object],[object Object]

Parkinson’s Disease ,[object Object],[object Object],[object Object],[object Object]

Other neuron loss: challenging issues ,[object Object],[object Object]

Peripheral vascular diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],Huang PP, et al . Thromb Haemost . 2007;98 ( 6 ): 1335-42 .

Diabetes ,[object Object],[object Object],[object Object],[object Object],Edmonton protocol

Facial contour defects ,[object Object],[object Object],Weiss RA, et al . Dermatol Surg . 2007;33 ( 3 ): 263-8 .

Stem Cells And Potential Clinical Applications

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Stem Cells And Potential Clinical Applications